药物依赖性

An individual can be addicted to and dependent on more than one drug.

同一个人可以对一种以上药物产生依赖性。

This is the website of Drug and Alcohol Dependence.

这是《药物与酒精依赖性》杂志的网站。

Antifolate Alimta derived from pyrrolo[2,3-d]pyrimidine is a multitargeted antitumor agent, it can inhibit at least five major folate-dependent enzymes: thymidylate synthase, dihydrofolate reductase, glycinamide ribonucleo -tide formyltransferase, aminoimidazole ribonucleotide formyl transferase and C-1 tetrahydrofolate synthetase(C1-S).

吡咯并[2，3-d]嘧啶类叶酸拮抗剂Alimta是一种多靶向的抗癌药物，它能抑制至少五种叶酸依赖性酶：胸苷合成酶、二氢叶酸还原酶、叶酰多聚谷氨酸合成酶、甘氨酰胺核糖核苷酸转甲酰酶及C1-四氢叶酸合成酶(C1-S)。。

Cross-dependence and cross-tolerance of opioids in the guinea-pig isolated ileum are studied.

研究了阿片类药物在豚鼠离体回肠中的交互依赖性和交互耐受性。

These kinases play an important role in the signal transduction of opioid receptors, tolerance and dependence of opiate.

它们在阿片受体的信号传导、阿片类药物的耐受性、依赖性等方面起重要作用。

Food, alcohol, smoking and dependent love addiction are all satiation drugs.

而食物、酒精、吸烟、依赖性爱情瘾都是满足需求的药物

Results:β-L-D4A was successfully synthesized and confirmed by IR, NMR and MS. Autoradiographic bands showed similar for supernatant and intracellular HBV DNA. Episomal HBV DNA was inhibited in a dose-dependent manner. EC50 of 3 -L-D4A was 0.2 μM. The experiment of cytotoxicity gained its IC_(50) 200 μM.

结果经一系列步骤合成的化合物β-L-D4A经红外光谱、质谱和核磁共振谱鉴定正确；2.2.15细胞培养上清液病毒DNA的Southern印迹、自显影结果显示药物对病毒的抑制呈明显的浓度依赖性，计算出EC_(50)为0.2μM；细胞毒性实验显示IC_(50)为200μM。

The incidence of cardiotoxic effects of trastuzumab appears to increase with exposure to anthracyclines, which mediate cardiac failure in a direct, dose-dependent manner.

曲妥珠单抗的心脏毒性作用发生率似乎随着患者暴露于蒽环类药物而增加，后者以一种直接、剂量依赖性方式介导心衰。

The clinical symptoms were markedly improved at 3 days of post-treatment,obvious difference of total mark was also appeared between the treatment group and control group.Conclusion It is suggested that inhalation of negative charge can strengthen the blood oxdation,regulate the funtions of nervous system,endosecretory and immunological system and decrease the dependence of drug against heroin.It is a better treatment for drug addicts.

通过吸入负电荷增强血液的氧化作用，对神经系统、内分泌系统及免疫系统功能有调整、改善作用，减少对戒毒药物的依赖性，是一种良好的对海洛因依赖者躯体戒断症状缓解的配合治疗方法。

Results: When the concentrations of artemisinin were 1×10^(-4), 1×10^(-5) and 1×10^(-6)mol/L, the growth of cells was inhibited remarkably in a dose-dependent manner. Fluorescence staining showed obvious apoptosis, such as karyopyknosis and agglutination. RT-PCR assay shows the expression of Caspase-3. Artemisinin could lead to the decrease of mitochondrial cytochrome c concentration, which in turn lead to the increase of cytoplasmic cytochrome c concentration.

结果：青蒿素的浓度为1×10^(-4)，1×10^(-5)，1×10^(-6)mol/L时，细胞生长受到显著抑制，并呈剂量依赖性；Hoechst33342/PI双荧光染色可观察到明显的核浓缩、凝集等细胞凋亡表现；RT-PCR检测到Caspase-3的表达；Western-blot检测1×10^(-5)mol/L药物处理细胞后线粒体细胞色素C表达水平下调，细胞浆出现明显细胞色素C蛋白条带。

With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务，乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐，因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。