药

Aim To investigate the pharmacokinetics of rabeprazole after intravenous, intraportal and intraduodenal administration at various doses and to clarify the impact of hepatic and intestinal first-pass effects to bioavailability of rabbits.

目的 研究雷贝拉唑在大白兔体内经十二指肠、门静脉与外周静脉等不同方式及不同剂量给药时的药代动力学，并探讨肠道、肝脏首过效应分别对其生物利用度的影响。

Patients were divided into 3 groups（each group was 46 patients）: group 1 received intercostals nerve freezing; group 2 used patient controlled epidural analgesia; while patients in group 3 received analgesic intramuscularly when needed.

术前将患者随机平均分为3组：组1（46例）为肋间神经冷冻组；组2（46例）为硬膜外置管给药组；组3（46例）为肌注给药组。

Group B received the treatment of removing fluids from the pericardial cavity with pericardiocentesis intermittently and intrapericardial injection.

将76例结核性渗出性心包炎患者随机分为A组和B组，均予以全身规则抗结核治疗。A组留置中心静脉导管引流及心包腔内注药，B组常规心包穿刺抽液及心包腔内注药。

Patients in treatment group were treated with ultrasound-guided drainage, followed by intrapleural injection of 125, 000 IU urokinase （diluted by 50 ml normal saline）, including 14 patients with pleural thickness〉 5 mm.

治疗组40例分为A，B两组，给予胸腔穿刺抽液引流并胸腔内注射尿激酶治疗，其中胸膜增厚〉5mm 14例为B组；对照组36例分为C，D两组，给予反复胸腔穿刺抽水治疗，其中胸膜增厚〉5mm 13例为D组；治疗组和对照组患者其他临床资料无差别，具有可比性；注药24h后抽液，B超定点测定首次注药前后的抽液量、胸膜厚度、纤维素分隔积分，差值结果作单因素卡方检验。

Methods: According to the mechanism of cough reflex, the c-fibres's role in the respiratory system, and the principle of isosterism. Here, a peripheral antitussive LD was regarded as a lead compound. Amino functional groups, as substituents at the 1-hydroxy group of the racemate of LD, were introduced into the structure of the molecule. These novel compounds were confirmed by 1H-NMR, MS spectrum. Their antitussive activities were studied on mice in sequential method. The EDT50, the stimulating time that caused cough by NH3 on half of mice, were measured. Then could caculated the ratio R between the EDT50 of the treated groups and control group.

根据咳嗽反射的机制及C-纤维在呼吸系统的作用，以外周镇咳药左羟丙哌嗪为先导化合物，依据电子等排原理，在其结构中引入氨基以取代羟丙哌嗪分子中1位的羟基，设计一系列未见报道的化合物（01-15）；并采用了一条适宜的路线进行合成，通过1H-NMR、MS确证结构；采用&序贯法&实验进行新化合物的镇咳活性研究，动物模型采用氨水引咳小鼠，获得引致半数小鼠咳嗽的氨水刺激时间（EDT50）及给药组EDT50与对照组的比值R。

The drug concentration in the janitrix and the abdoninal cavity is higher than that in the abdoninal aorta and peripheral venous after the treatment.The tissue of liver is about the same to kidney .The durg concentration in the janitrix and tissues is high and invariant for a long time. TACE and sequential chemotherapy inhibit the development of the cancer synergily and the latter cannot induce the toxic reaction.

化疗药物腹腔给药后门静脉血中，腹腔液中药物浓度显著高于腹主动脉，外周静脉血；腹腔给药后，肝组织中药物浓度高于肾组织；药物在门静脉，组织中存在较高的药物浓度，递减缓慢，浓度恒定，维持时间长；肝动脉化疗栓塞术有效地控制了肿瘤的大小，序贯化疗亦有效地抑制了肿瘤的发展和转移，两者间作用相互协同；序贯化疗不增加肿瘤病人的化疗毒副反应。

These results indicated that palmatine had one common binding site on the immobilizedβ_2-AR column,the association constant was 2.93×10~4 L/mol at pH 7.2 and 25℃,while jatrorrhizine had two bingding sites,the association constants at these two sites were 1.93×10~4 and 1.56×10~5 L/mol,respectively.And the molar ratio of weak bingding sites to strong binding sites was 93:7.Palmatine and jatrorrhizine had competed for low-affinity site in immobilizedβ_2-AR.

结果表明，盐酸巴马汀与β_2-AR只有一类结合位点，在流动相pH 7.2，温度25℃时盐酸巴马汀与β_2-AR的结合常数为2.93×10~4 L/mol；盐酸药根碱与β_2-AR有两类结合位点，在这两类结合位点上的结合常数分别为1.93×10~4和1.56x10~5L/mol，两类结合位点数的比值为93：7，且盐酸巴马汀和盐酸药根碱竞争低亲和力的结合位点。

Conclusions1. To use the corresponding scheme of producing medicine serum for different chinese traditional medicine.2. Liu-Shen-Wan medicine-serum can induce apoptosis of HL-60 cell. It is one of mechanisms in treating leucemia by Liu-Shen-Wan.

1 中药血清药理学含药血清的制备应区分不同的中药，采用相应的方案。2 六神丸含药血清能诱导细胞凋亡，这可能是六神丸治疗白血病的机制之一。

For better understanding the relationship between chemistry composes and activities, and promoting the competitive strength, 16 benzene derivatives (three new compounds and a novel skeleton) were isolated from Ligularia veitchiana which were collected in Hubei province.

为了更好的了解植物药中的化学成分及药效关系，提升我国植物药在国际市场的竞争力，我们对采自湖北的离舌橐吾进行了系统的化学成分分离，得到16个苯的衍生物，其中，新化合物三个，新骨架化合物一个。

It is the first time to establish the revered-phase HPLC method to determine concentrations of loganin and morroniside in plasma and to obtain their pharamacokinetic parameters and characteristics.

首次建立了山茱萸注射液中马钱素和莫诺苷血药浓度的HPLC测定方法，阐明了山茱萸中马钱素和莫诺苷的药代动力学参数，方法的专属性强，结果可靠。

In the negative and interrogative forms, of course, this is identical to the non-emphatic forms.

。但是，在否定句或疑问句里，这种带有"do"的方法表达的效果却没有什么强调的意思。

Go down on one's knees;kneel down

屈膝跪下。。。下跪祈祷