药

The growth inhibiting rate of T24 cell lines were detected by MTT methods, apoptosis of cells were detected by flow cytometry, the mechanism of apoptosis was analyzed by detecting the protein expression of Bcl-2, Bax, Caspase-9, Caspase-3 and cytoplastic protein Cytochrome C. 4 We injected live T24 cells into the subcutaneous space of nude mice and successfully built up the animal model of bladder carcinoma. The effect of CS-PAA-EPI polymer magnetic microspheres targeting chemotherapy was investigated by HE staining, TUNEL ,tumor weight and volume inhibition rate. Results: 1 TEM revealed that the CS-PAA polymer magnetic microspheres were regular spherical shape,the average diameter was 80nm in dry condition. By controlling the pH value of the medium,polymers had positive or negative zeta potential. VSM showed the CS-PAA polymer magnetic microspheres had superparamagnetic. The diameter of CS-PAA-EPI polymer magnetic microspheres were 200nm in solution by DLS examining,the embedding ratio was 20%,the EPI loading rate was 15%, which was higer than reported in other articles. 2 Raw eye observation found that the rat"s bladder of treatment group was brown color,which meaned the aggregation of iron particles, compared with the control group, iron stain found iron particles were assembled in rat"s bladder of the treatment group, the amount of iron particles in liver and spleen were less obviously.

研究结果：1合成的CS-PAA磁性聚合物微球呈球形，大小均一，TEM测定其干态下粒径为80nm左右，磁化曲线证实具有超顺磁性，具有一定的PH敏感性，固载表柔比星后，水溶液性状稳定，无沉淀物，DLS测定直径约200nm左右，测定载药率为15％，较文献报道高，包封率为20％。2肉眼观察试验组大鼠膀胱表面呈褐色，可见大量的Fe粒子聚集，普鲁士兰染色法显示，试验组大鼠膀胱壁内有大量的Fe粒子，分布至膀胱壁全层，与对照组大鼠相比，试验组大鼠的肝、脾内的Fe粒子聚集量明显降低；HPLC测定结果与Fe染色相同；高剂量磁性CS-PAA-EPI生理盐水组及单纯EPI生理盐水组均在给药后14天出现血肌酐和尿素氮的升高，其他组大鼠血生化指标没有明显变化。3MTT法发现，高、中、低剂量磁性CS-PAA-EPI生理盐水组在外加磁场的协同作用下杀伤T24细胞效应明显高于单纯的EPI生理盐水组，FCM发现试验药物组可引起明显的肿瘤细胞凋亡，试验药物治疗组细胞胞浆内出现了由线粒体释放出的细胞色素C，试验组细胞Bcl-2蛋白减少，Bax蛋白变化不明显，Caspase-3、Caspase-9蛋白受到了激活活化。4高、中、低剂量磁性CS-PAA-EPI生理盐水组的瘤重抑制率和瘤体积抑制率均明显高于单纯的EPI生理盐水组(P＜0.01)，其中高剂量组的抑制率最高。

A month after that, Mrs. Darr said, both were hospitalized for a week and given a diagnosis of bipolar disorder and prescriptions for antipsychotic, antidepressant and sleeping medicines.

Darr夫人说，一个月后，他们两个双双住院，被诊断为双相性精神障碍，使用抗精神病药、抗抑郁药和睡眠药物。

Flavonoid compound was isolated from SSB, and then the serum contained water decoct agent of SSB or flavonoid compound were prepared with mice.

从千里光中分离出黄酮类化合物，然后通过给小鼠灌胃制备千里光水浸液的含药血清和黄酮类化合物的含药血清。

MethodsFlavonoid compound was isolated from SSB, and then the serum contained water decoct agent of SSB or flavonoid compound were prepared with mice.

方法从千里光中分离出黄酮类化合物，然后通过给小鼠灌胃制备千里光水浸液的含药血清和黄酮类化合物的含药血清。

It showed a dosage dependent degrease of blood glucose level. The effect after intestinal administration is better than it after oral administration.

比较口服经胃给药和肠道注入给药，发现胰岛素油溶液肠道注入后的降血糖效果更佳。

Results634 species of wild plants are growing in this area, of which 396 species are capable of resolving heat, detoxifcation, dispelling wind-evil and dehumidify.

结果记录该地区野生植物634种，其中药用植物396种，以清热解毒药、祛风湿药等见长。

Encapsulated psoralen were evaluated by dialyzation using psoralen gel as the control. Changes of liposome????encapsulated psoralen and release rate were detected during a 3????week storage at 4 ℃ for evaluating the stability of the liposomal formulation.

以同浓度的补骨脂素凝胶为对照，用透析法检测补骨脂素脂质体凝胶的体外释药模式，并对其在4 ℃下贮存3周的释药稳定性进行研究。

Objective To investigate the functional mechanism of Chinese drug disodium cantharidinate reversing multidrug resistance of tumor cells.

目的 观察斑蝥酸钠对多药耐药的白血病细胞(K562/AO2)细胞是否有逆转作用，并初步探讨其逆转机制。

Ten transformants and 10 conjugons showed high-level resistance against aminoglycoside antibiotics,all of which the value of MIC＞256μg/mL carried armA gene.Conclusions:The Ab clinical isolates from burn ward in Gansu Province People\'s hospital have high drug-resistance.16S rRNA methylases gene exsist in Ab and locate in plasmid chromosome.They are easily disseminative,which demonstrated a very high level of resistance to various aminoglycosides.

甘肃省人民医院烧伤病房鲍氏不动杆菌临床分离株有非常高的耐药率，16S rRNA甲基化酶基因armA在鲍氏不动杆菌中存在，且位于质粒染色体上，易于传播和扩散，导致所有氨基糖苷类抗菌药物高水平耐药。

A clinical effective rate of 81.8% was obtained after treated with doxofylline for 1 week or 6 weeks,with a lung-function improve drate of 59.1% similar to those of sustained-released theophylline.

连续给药1周或4周，试验组临床有效率为81.8%。连续给药后PEF明显升高，肺功能改善有效率为59.1%。上述结果均与对照组相似。

Breath, muscle contraction of the buttocks; arch body, as far as possible to hold his head, right leg straight towards the ceiling (peg-leg knee in order to avoid muscle tension).

呼气，收缩臀部肌肉；拱起身体，尽量抬起头来，右腿伸直朝向天花板（膝微屈，以避免肌肉紧张）。

The cost of moving grain food products was unchanged from May, but year over year are up 8%.

粮食产品的运输费用与5月份相比没有变化，但却比去年同期高8％。