药

Establishment of drug resistant cell line in vitro remains the main way for investigation in the mechanisms of chemoresistance.

体外建立耐药细胞系仍是目前研究耐药机制的主要方法，但关于鼻咽癌耐药细胞系的研究并不多。

Objective: To explore the role of hypoxia-inducible factor-1α(HIF-1α) in formation of multidrug resistance induced by microenvironment and to find a new and effective molecular target on preventing and reversing chemoresistance in hepatocellular carcinoma.

目的探讨缺氧诱导因子1α(HIF-1α)在微环境诱导的肝癌多药耐药表型形成过程中的作用和地位，并为预防和逆转肝癌耐药提供有效的新的分子靶点。

With the collapse model of chous and the modified PER theory, one dimension calculation was obtained to describe the process such as liner collapse, jet formation, jet stretch and penetration of different explosive filled structure by Matlab tool and good result was attained.

采用周培基的压垮模型和改进的PER理论，针对不同装药结构的药型罩借助Matlab语言实现了药型罩压垮、射流形成、射流拉伸、侵彻等过程的一维数值计算，获得了较好的计算结果。

In the first way, the other five medicines except Radix sophorae flavescentis against NDV was better. In the second way, the effect of Herba houttuyniae, Patrinia villosa juss, Rhizoma polygoni cuspidati and Radix isatidis to NDV was better, but Radix sophorae flavescentis and Folium isatidis had little effect. In the third way, Radix isatidis, Herba houttuyniae, Patrinia villosa juss were more effective than Folium isatidis, Rhizoma polygoni cuspidate. In short, the effects of Radix isatidis, Patrinia villosa juss and Herba houttuyniae on NDV were higher.The first of three more satisfactory complex composites obtained from the experiment was Folium isatidis, Herba houttuyniae, Rhizoma polygoni cuspidati, Patrinia villosa juss and Radix sophorae flavescentis.

在第一种加药方式中：只有苦参没有产生作用，其余五种药物抗NDV的作用均较强；在第二种加药方式中：鱼腥草、败酱草、虎杖、板蓝根效果较好，而苦参及大青叶则几乎不起作用；在第三种加药方式中：板蓝根、鱼腥草、败酱草有较强的作用，大青叶、虎杖次之，由以上结果可以看出在三种方式中，板蓝根、败酱草和鱼腥草抗NDV的作用较强。

Our main products include 5-Methyl-2-pyrazinecarboxylic acid series, Guanine series, Folic acid series, Methyl Cyanoacetate and Ethyl cyanoacetate series, we also have made great contribution in the development of cardiovascular drug, stomach drug, anti-inflammatory drug and antidepressants, such as Nizatidine, Acipimox, Glipizide, Zaltoprofen and Pregabalin, which have been put into production on large scare.

公司主要产品有5-甲基吡嗪-2-羧酸系列，鸟嘌呤系列，叶酸，氰乙酸甲酯，氰乙酸乙酯系列，在心血管药、胃药、消炎药、抗抑郁药等新品开发上有重大建树，先后研制成功，形成批量生产，如尼扎替丁、阿西莫斯、格列吡嗪、扎托洛芬、普瑞巴林，同时具备为客户定制化学品的能力。

The results show that the value of burning rate pressure exponent of propellant and its change law can bring about a great change of interior ballistic behavior, The new type high-energy propellant whose burning rate pressure exponent is decrescent as pressure increasing can obtain higher interior ballistic piezometric efficiency, and reduce the sensitivity of bore pressure and muzzle velocity on loaded conditions of propellant.

结果表明，发射药燃速压力指数的大小及其随压力的变化规律对内弹道性能有很大的影响，对于燃速压力指数随压力升高而减小的新型高能发射药，可获得较高的内弹道示压效率，降低膛压和弹丸初速对发射药装填条件的敏感性。

RESULTS:The automatic drug dispensing system could raise the speed and accuracy of drug dispensing, improve the health condition,decrease medicine pollution,decurtate waiting time of nurse, improve the quality of pharmaceutical service.

结果：全自动口服药品摆药机可提高摆药的速度和准确性，改善卫生状况，减少药品污染，缩短护士领药时间，改善药学服务质量。

Medicamentous liver lesion may occurred more commonly in HBsAg positive patients after antituberculous therapy.bipheny dicarboxylate and glucurolactone can only prevent and cure part of them.Drug anaphylactic reaction may play a role in medicamentous liver lesion.

HBsAg病例接受抗结核治疗易发生药物性肝损害，联苯双酯、葡醛内酯只对部分药物性肝损害有预防和治疗作用，而药物过敏反应可能在抗结核药所致药物性肝损害中起一定作用。

In order to understand the drug resistance mechanism of HIV-1 integrase mutually existed for multiple drug-resistant strains to the most potent IN inhibitors diketo acids, three S-1360-resistant HIV-1 strains were selected and molecular docking and molecular dynamics simulations were performed to obtain the inhibitor binding modes.

为了解DKAs引起的多种耐药株共有的耐药性机理，选择3种S-1360引起的IN耐药突变体，用分子对接和分子动力学模拟，研究了野生型和突变型IN与S-1360的结合模式，基于该结合模式探讨了3种耐药突变体所共有的耐药性机理。

Pharmaceutical characteristics of dimethylamino ethyl(4-chlorophenylmethfoxy )acetate hydrochloridein rabbit was studied and several parameters at different timeand way of medicine administration were determined.

研究了4－氯代苯甲氧基乙酸二甲氨基乙酯盐酸盐在家兔体内的药代动力学，测定了不同时间不同给药方式家兔体内的血药浓度及动力学参数。

On the other hand, the more important thing is because the urban housing is a kind of heterogeneity products.

另一方面，更重要的是由于城市住房是一种异质性产品。

Climate histogram is the fall that collects place measure calm value, cent serves as cross axle for a few equal interval, the area that the frequency that the value appears according to place is accumulated and becomes will be determined inside each interval, discharge the graph that rise with post, also be called histogram.

气候直方图是将所收集的降水量测定值，分为几个相等的区间作为横轴，并将各区间内所测定值依所出现的次数累积而成的面积，用柱子排起来的图形，也叫做柱状图。