药

The IR analyses proved that the polymerization effects really occurred. The BET adsorption test indicated that the adsorption amount of MIPMs to LMD was as three times as that of non-imprinted microspheres. The controlled release test indicated that the release ratio of LMD on NIPMs was linearly increased with increasing time, which suggests that the release process is completely controlled by diffusion. Meanwhile, the release ratio of LMD on MIPMs was curvedly increased with increasing time, which indicates that the release process is controlled by both diffusion and the imprinting effect.

药物扩散实验表明， LMD在非印迹微球上的释药率几乎与时间呈直线关系，说明其释药过程完全受扩散控制；而LMD在MIPMs上的释药率则呈曲线上升趋势，说明其释药过程除了受扩散控制外，还受到药物模板分子与MIPMs之间的印迹效应的协同作用的控制，从而达到了缓释药物分子的目的。

Results: Tyroserleutide can significantly increase the life span of H22 tumor-bearing mice by 50-70% in dosages of 20ug/kg/d-80ug/kg/d,specially the high dosage of 80ug/ml can significantly increase the life span by 69.24%; Tyroserleutide can inhibit the growth of transplanted hepatocellular tumor BEL-7402 in nude mice,the rate of tumor inhibition was25-50% in dosages of 40-320ug/ml ,the inhibition rate of 160ng/ml was 44.03%; Tyroserleutide could inhibit the growth of H22 and BEL-7402 tumor in a dose-dependent manner. Simultaneously, tumoricidal activity of tyroserleutide against BEL-7402 cell line in vitro was observed hinger when compared with the control group(P.05).The inhibition effect of 72hrs was higher than 24hrs,48hrs,96hrs.And specially the high dosage of 160ug/ml can significantly inhibit growth of tumor cell by 19.36%. Tyroserleutide can activated PEM and marked enhance cytotoxicity andphagocytosis functions in vitro and in vivo. The OD values of cytotoxicity were observed hinger when compared with the control group(P.05).The cytotoxicity of macrophages activated by tyroserleutide against BEL-7402 and B16-F10 was 35.58%,61.2% in vitro and21.39%,47.63% in vivo. The cytotoxicity rate of nude mice PEM was 32.86%,73.07% in vivo. Furthermore, tyroserleutide alone could stimulated the production of IL-1B TNF- a and NO by M . Tyroserleutide and LPS could synergistically activated M producing more cytotoxicity effectors. Conclusion: Tyroserleutide had inhibition functions against hepatoma carcinoma .Its possible mechanisms were related to the affect that Tyroserleutide could inhibit tumor cell directively and induce tumor cells apoptosis or death effectively.

结果：酪丝亮肽能显著延长腹水型肝癌H_(22)小鼠的生存时间，给药剂量为80μg／kg／d时疗效最显著，达到69.24％，在20μg／kg／d-80μg／kg／d剂量范围内生命延长率为50-70％，给药剂量与荷瘤鼠生存时间呈现一定量效关系；酪丝亮肽能显著抑制人肝癌BEL-7402移植瘤裸鼠的肿瘤生长，给药剂量为160μg／kg／d时疗效最显著，抑制率为44.03％，并且在40-320μg／kg／d剂量范围内抑制率为25-50％，给药剂量与肿瘤抑制率呈现一定量效关系；酪丝亮肽体外对人肝癌BEL-7402细胞生长有一定的抑制作用，在作用72hrs时各浓度酪丝亮肽对肿瘤细胞的抑制作用较24hrs、48hrs、96hrs明显，其中浓度为100μg／ml时抑制率达19.36％；酪丝亮肽体内外均能增强小鼠腹腔巨噬细胞对肿瘤细胞的杀伤：体外作用中巨噬细胞对BEL-7402、B16-F10的杀伤功能明显增强，与效应细胞对照组相比有显著性差异(P＜0.05)杀伤率分别达到35.58％、61.2％；体内作用中巨噬细胞对BEL-7402、B16-F10的杀伤功能明显增强，与生理盐水对照组相比有显著性差异(P 。05)，杀伤率分别达到21.39%、47.63%；裸鼠腹腔巨噬细胞经酪丝亮肤作用后对BEL一7402、B 16一F10杀伤功能明显增强，与生理盐水对照组相比有显著性差异(P.05)，最高杀伤率分别达到32.86%、73.07%；酪丝亮肤能增强单核巨噬细胞系统的吞噬功能，吞噬指数与生理盐水组比较有显著性差异(P.05)；酪丝亮肤体外作用能促进小鼠腹腔巨噬细胞分泌合成细胞毒效应分子IL一lp、TNF一Q和NO，与效应细胞对照组相比有显著性差异(P.05)；酪丝亮肤体内作用能促进小鼠腹腔巨噬细胞分泌合成细胞毒效应分子IL一lp、TNF一Q和NO，与生理盐水对照组相比有显著性差异(P.05)；酪丝亮肤能促进鼠巨噬细胞株R戌W264.7分泌合成IL一1p和NO，IL一1日、NO水平分别在酪丝亮肤作用24hrs、12hrs时达到高峰，酪丝亮肤单独应用能提高巨噬细胞的分泌合成功能，而且酪丝亮肤能与LPS协同作用刺激巨噬细胞的细胞毒效应分子分泌合成。

For the submunition ejection pattern predet ermined time and order, based on the kinematics equations for ejection schedulin g of submunition and the concept of submunition ejecting sequence, the influence of ejection scheduling of submunition on the attitude of airborne dispenser is analyzed.

针对子弹药定序抛撒方式，在建立子弹药时序抛撒动力学方程的基础上，基于子弹药定序抛撒时序序列的概念，研究分析了抛撒过程中子弹药抛撒时序变化对布撒器姿态的影响，进而提出了对子弹药时序抛撒系统设计的初步要求，可为机载布撒器子弹药抛撒系统设计提供参

Overexpression of MDR1, GST-π, p53 mRNA and their corresponding proteins in epithelial ovarian cancer participated in the formation of multidrug resistance in ovarian cancer and P53 may play a indirected role through regulating the expression of MDR1、GST-π.

卵巢癌化疗耐药与耐药基因GST-π、MDR1过表达及细胞凋亡相关基因P53突变密切相关，突变的P53可能通过调控耐药基因GST-π、MDR1而间接发挥其耐药作用。

Objective:To investigate the relationship between the expression of P-glycoprotein and the breast cancer resistance protein gene in acute myeloblastic leukemia.

目的：研究多药耐药蛋白和乳腺癌耐药蛋白基因在急性髓系白血病中的表达以及它们与临床耐药之间的关系。

Presently, the studies on multidrug resistance mechanism, reversor and associated exterior experiments in vivo and in vitro from different points of view and levels show that multidrug resistance is the result of common action in many factors. In recent years nonrepresentative mechanism of multidrug resistance becomes more and more significant.

肿瘤细胞产生耐药性成为许多肿瘤治疗成败的关键，也是血液肿瘤化疗失败的重要原因，目前人们从不同的角度和水平对耐药的发生机制、逆转耐药的药物研究及相应的体内外实验等进行研究，指出多药耐药是多种因素共同作用的结果。

New antifungal agents have been developed over the past years based on the discovery of many new target sites of Candida albicands. For example, Echinocandins, aiming at the cell wall of Candida albicands, showed strong antifungal activities to fluconazole resistant candidas and fungal biofilm. Moreover, because β-glucan synthase does not exist on the cell membrane of mammalian cells, Echinocandins has a low toxicity and a promising clinical future. Though the mechanism of Histatin is not clear, it has strong activity not only on candida resistant of polyene and azole, but also to Candida parapsilosis, Candida krusei and Cry ptococcus neoformans. Berberine and Ocimum gratissimum L. were also found to have prominent anti-fungi activities.

近年来相继提出了许多抗白念珠菌药物作用的新靶点并成功开发出一些活性强大，疗效确切的抗真菌药，如以真菌细胞壁为靶点开发出棘白菌素类药物卡泊芬净、米卡芬净等，该类药物主要抑制β-葡聚糖合成酶，体外对氟康唑耐药的念珠菌属及真菌生物被膜表现出强大的抗菌活性，又由于β-葡聚糖合成酶在哺乳类动物细胞内不存在，故具有高效低毒的临床效果，是一极具前途的新型抗真菌药；以真菌细胞膜为靶点开发出Histatin类药物，虽然作用机制目前还不完全明了，但其作用不同于临床常用的多烯类和氮唑类，并已经发现Histatin5对两性霉素B和氮唑类耐药的念珠菌有效，并且对非白念珠菌如光滑念珠菌、克柔氏念株菌、隐球菌等也有杀灭作用；通过对植物药物的研究发现黄连素和丁香罗勒Ocimum gratissimum L。

Single proton emission computer tomography and X-Ray film were taken to observe the allocation of the drugs.Results (1) Pelvic and periaortic nodal 5-FU concentrations of RP were 60～106 and 76～119 times of that of IP respectively.(2) The nodal 5-FU concentrations on repeated injection side were 16～20 times of that on control sides of RP.(3) There was no complications or adverse effect observed.(4) 5-FU was allocated to the space including the external iliac, internal iliac, obturator, deep inguinal and common iliac lymph nodes and also up to the periaortic lymph nodes.

结果 (1)腹主动脉旁淋巴结5-FU浓度，腹膜后化疗是腹腔化疗的76～119倍；盆腔淋巴结5-FU的浓度，腹膜后化疗是腹腔化疗的66～106倍；(2)腹膜后化疗重复注药，注药侧5-FU浓度为未注药侧的16～20倍；(3)腹膜后化疗与腹腔化疗均无明显的毒副作用；(4)经盆腔腹膜外间隙给药，药物能从盆腔上行至腹主动脉旁淋巴结及其周围。

Results: DNA content of the plasmodia not treated with any drugs was not changed in 24 hours,while benflumetol could decrease the DNA content: the DNA content began to decrease 2 h after the drug administration and reached the minimum by 16 h, but somewhat increased at 24 h after administration.

结果：对照组疟原虫DNA含量在各时间点没有显著变化。本芴醇单次给药后，随时间推移疟原虫DNA含量逐渐减少，药后2 h两给药组疟原虫红内期 DNA含量开始降低，到16 h降到最低，但药后24 h DNA含量又有所回升。

Existing calculation methods for burning surface don't well agree with the experimental data with complicated grain. In order to eliminate the error, tests data are used to correct the prefigurative result generally, and it is impossible to calculate burning surface of grain with crack.debond and wtith changing burning rate of propellant.

目前现有的固体装药燃面算法，在计算复杂装药燃面时仍有较大误差，为消除这种误差往往需要用试车结果给予修正；同时在计算含缺陷装药燃面和处理装药因批次燃速变化时的燃气加质更是束手无策。

The absorption and distribution of chromium were studied in ryeusing nutrient culture technique and pot experiment.

采用不同浓度K2CrO4(0，0.4，0.8和1.2 mmol/L)的Hoagland营养液处理黑麦幼苗，测定铬在黑麦体内的亚细胞分布、铬化学形态及不同部位的积累。

By analyzing theory foundation of mathematical morphology in the digital image processing, researching morphology arithmetic of the binary Image, discussing two basic forms for the least structure element: dilation and erosion.

通过分析数学形态学在图像中的理论基础，研究二值图像的形态分析算法，探讨最小结构元素的两种基本形态：膨胀和腐蚀；分析了数学形态学复杂算法的基本原理，把数学形态学的部分并行处理理念引入到家实际应用中。