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The activity of pyruvate carboxylase depends on the presence of acetyl CoA so that more oxaloacetate os made when acetyl CoA levels rise.

丙酮酸羧化酶的活性依赖于乙酰-CoA 的存在。因此,当乙酰-CoA,水平上升时,会产生更多的草酰乙酸。

It is also an important intermediate of GLYCOLYSIS, being the immediate precursor of pyruvic acid.

它也是糖酵解过程中重要的中间物,是丙酮酸的直接前体,在乙醛酸循环中由草酰乙酸产生而合成葡萄糖。

Why did the addition of oxaloacetate or malate stimulate oxygen consumption?

为什么草酰乙酸或苹果酸的加入促进了氧的消耗?

Why was the amount of oxygen consumed so much greater than the amount necessary to completely oxidize the added oxaloacetate or malate?

为什么加入草酰乙酸或苹果酸后耗氧量比完全氧化所需的多出如此之多?

Malate dehydrogenase which catalyzes the reversible reaction from oxaloacetate to malate ubiquitously exists in nature.

苹果酸脱氢酶普遍存在于各种生物中,它负责催化草酰乙酸和苹果酸之间的相互转换。

How is oxaloacetate that is lost from the cycle replenished ?

在生物合成反应中丢失的草酰乙酸是如何回补的?

All dates were analyzed by the principal component analysis through using the SIMCA-P 10.0 software. Result: The PCA demonstrated that the metabolome between treated group and control group had difference in rat urine sample after of 22 days administrated, for treated group 169 kinds of biomarkers were found including oxalacetic acid, malic acid, 2-ketoglutaric acid, NE, arachidonic acid, 5-HIAA and other compounds, the result was consistent with pharmacological effects of R.coptidis , such as antiinflammatory, inhibiting biosynthesis of CA biosynthesis, anti-central nerve and energy metabolism inhibition.

结果:给药22 d,黄连组与对照组大鼠尿样代谢组有较大差异,发现了169个生物标记物,其中可能的化合物为草酰乙酸、苹果酸、2-酮戊二酸、去甲肾上腺素、花生四烯酸、5-羟吲哚乙酸等物质,这与黄连抗炎、阻止儿茶酚胺的生物合成、抑制中枢神经、降低能量代谢的药理作用相一致。

In the last reaction of the citric acid cycle, malate is dehydrogenated to regenerate the oxaloacetate necessary for the entry of acetyl-CoA into the cycle

在三羧酸循环的最后一个反应中,苹果酸脱氢重新生成草酰乙酸以供乙酰辅酶A进入循环所必需

Citrate synthase plays a key role in regulating TCA cycle and is responsible for catalysing the synthesis of citrate from oxaloacetate and acetyl CoA.

柠檬酸合成酶在TCA循环中起着关键的调节作用,它催化乙酰辅酶A与草酰乙酸缩合成柠檬酸。

Transport of oxaloacetate Oxaloacetate, the product of the first step in gluconeogenesis, must leave the mitochondrion and enter the cytosol where the subsequent enzyme steps take place.

草酰乙酸的运输在糖异生作用中,第一部产物草酰乙酸必须离开线粒体并进入胞质溶胶,在胞质溶胶中进行以后的酶促反应步骤。

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