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茶碱

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In control group(n=38) the patients were given aminophylline tablets in addition to common antiphlogistic nebulization treatment;while in treat group(n=42) the aminophilline load were applied to assist the common antiphlogistic nebulization treatment.results in comparison with control group,the patients in treat group were more fastly liberated from asthmatic couphing and dyspnea(p.05),needed fewer days in hospital(p.05) and had an elevated cure rate(p.05).conclusion aminophylline load application as the assistant way is an effective,safe and economical method to fastly alleviate the dyspnea caused by bronchiolitis.

结果 氨茶碱负荷量应用治疗毛细支气管炎可迅速缓解患儿的喘憋和呼吸困难,缩短住院天数和提高治愈率。结论在普通消炎雾化治疗基础上加用氨茶碱负荷量是快速缓解毛细支气管炎喘憋、呼吸困难的有效、安全、经济的方法之一。

At the same time,this therapy overcomes the limitations in time and TCM types of sydrome of dog day moxibustion,so it is effective to all types of asthma,especially for prevention and treatment of asthenic asthma in catabasis and cold asthma in acute stage with significant efficacy.2.In comparison of effects of attack stage and remission stage, aminophylline group is better than treatment group in attack stage.

在发作期和缓解期的疗效比较中,在发作期,氨茶碱的疗效优于辨证贴药组;在缓解期,辨证贴药组的疗效优于氨茶碱组,可见对于哮喘患者缓解期的治疗有了新的治疗(来源:Ab7BC论文网www.abclunwen.com)方法,而且该疗法安全有效,操作简单,价格便宜,具有广泛的应用前景。3。

Results ① Plasma theophylline concentrations were in the range of 5~20 μg/mL in 668 patients of 908 patients (except one patient who committed suicide with theophylline), surpassing 20 μmL in 76 patients, and lower than 5μg/mL in 164 patients.

结果 ①除服茶碱自杀的1例病人外,其余908例病人中,首次检测茶碱血药浓度在5~20μg/mL范围内668例,超过20μg/mL者76例,低于5μg/mL者164例。

Its use as a therapeutic agent necessitates close study because the metabolism of theophylline varies between individuals.

茶碱作为一种治疗药物,对其检测是非常必须和重要的,这是因为茶碱在个体代谢上存在差异。

The experiential mathematical model was built up by using stepwise regression and optimized with modifiedsimplex method, then five components- amidopyrine ,phenacetine,theophylline, theobromine and caffeine in compound theophyllinitablets were determined simultaneously.

利用逐步回归分析法建立经验数学模型,再运用改良单纯形法进行优化,同时测定复方茶碱片中的五种组分——氨基比林、非那西丁、茶碱、可可碱和咖啡因的含量,其回收率分别为99.5%、100.2%、101.2%、100.2%和99.2%,RSD分别为1.51%、1.03%、4.44%、2.47%和3.12%。

Methods The UV method for determination of asarone and diprophlline in their mixed solution was established, by which they were assayed when the mixed solution was set at 24 during 6h.

将细辛脑、二羟丙茶碱加入葡萄糖注射液中,混合均匀后,建立细辛脑与二羟丙茶碱混合液紫外分光光度法含量测定方法,分析混合液在室温下(25℃)8 h内2药含量,并观察其pH值、外观、微粒及紫外光谱及峰形变化。

Methods Asphyxial cardiac arrest was induced by clamping the endotracheal tube.

方法采用呼气末夹闭气管方法建立起大鼠心脏停搏模型。48只大鼠随机分为生理盐水对照组、氨茶碱组、肾上腺素组、氨茶碱与肾上腺素合用组,心肺复苏后1h处死动物尸检观察心脏硬度。

Neurons treated with 20-mmol/L-theophylline did not show 180bp ladder characteristic of endonuclear activation on its DNA gel electrophoresis. The [cAMP]i of the neurons rose after being incubated together with different concentration theophylline (5-80 mmol/L) for 15 minutes in CO2 incubator and the prometed range relied on the dose of theophylline.

100%,量效关系有高度显著性(P.01),EC50=2.97mmol/L;经茶碱(20mmol/L)处理的细胞,其DNA凝胶电泳带没有&梯子&状分布;与不同浓度茶碱(5-80 mmol/L)在CO2培养箱孵育15 min,小脑颗粒神经元内cAMP均升高,且是剂量依赖性的。

TREATMENT: Except for anti-coagulation therapy, aminophyllini was an inexpensive medicine to treat PTE, it could largly lower Hb and Hct by reducing the secretion of EPO. Its defect was rechallenge of PTE with the drug stopped, and repeated administration was still effective. The side effect was exciting symptoms. Enalapril was a storng hypotensor which could also greatly lower Hb and Hct with the decline in PRA/AT-Ⅱ, and then decreasing serum EPO. In this therapy blood pressure shonld be monitored to prevent from postural hypotention. At last, it showed that diltiazemi had no obvious effect on PTE.

四、治疗研究:分别以氨茶碱、恬尔心、Enalapril来治疗PTE病人,发现氨茶碱能明显降低PTE病人的Hb及Hct,且该作用与EPO降低有关,其缺点是停用后可引起复发,但继续服用仍有效,该药的副作用主要为头痛、失眠等兴奋症状;Enalapril不但能显著降低Hb及Hct,还可治疗难治性高血压,适用于伴有高血压的PTE病人;恬尔心对PTE的治疗作用不大。

The vitro release result which used theophylline as model drug showed, the release behavior can divide to sharp release 、 relaxedly release and equilibrium release periods.

茶碱为模型药物,模拟体外释放的结果表明,共聚物胶束对茶碱的体外释药可分为突释、缓慢释放、平衡释放三个阶段。

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