苯酰胺

In search of safer and more effective fungicidal compounds,eight N-(4,6-disubstitued pyrimidin-2-yl)- benzamide s were designed and synthesized.

为了寻找高效、安全的杀菌活性化合物，设计并合成了8个N-(4，6-二取代嘧啶-2-基)苯甲酰胺类化合物，其化学结构经1HNMR、IR、LC/MS和元素分析确证。

A transformant line obtained by transfection of NTH3T3 cells with c-Ha-T24-ras gene was treated with 5mmol/L benzamide,an inhibitor of PARP enzyme for 4 weeks.Some changes in cellular properties of the transformant line were observed.

用 5mmol/L PARP抑制剂苯甲酰胺处理经c-Ha-T24-ras活化癌基因转染得到的转化细胞系，处理4周后发现转化细胞系的某些细胞生物学特性发生了改变，呈现出正常细胞的某些特性。

After treatment of benzamide which is an inhibitor of poly polymerase,β-galactosidase activity assays and PCR analysis were performed to test the deletion of LacZ gene and c-Ha-T24ras gene. The results showed that:(1)LacZ gene was deleted from both A13.4-NIH3T3 cells and B12.7-NIH3T3 cells, but neigher from A13.4-HeLa cells nor B12.7-HeLa cells. So it is possible that there is cell line specificity in gene deletion induced by BA.(2) In A13.4-NIH3T3 cells, LacZ gene and c-Ha-T24ras gene were completely deleted at the same time.(3) The transcription activity of exgenous DNA fragment may have same effect on its sensitivity to the deletion induced by BA.

用聚ADP核糖聚合酶的NAD位点抑制剂苯甲酰胺分别处理四种转化细胞后，检测细胞中整合的外源LacZ基因与c-Ha-T24ras基因的删除情况，结果如下：BA诱导的基因删除可发生于NIH3T3转化细胞系，但不能发生于HeLa转化细胞系；位于同一外源表达载体上的LacZ基因与c-Ha-T24ras基因的删除过程是同步的；外源整合DNA片段的转录强度可能直接影响其被BA诱导删除的敏感性。

Trans-3-phenylglycidate ethyl ester was prepared from benzaldehyde and ethyl chloroacetate through Darzens condensation reaction.

以苯甲醛和氯乙酸乙酯为原料，经Darzens 缩合反应合成了反式-3-苯基缩水甘油酸乙酯，然后在25℃以氨水开环得赤型-3-苯基异丝氨酰胺。

Polyelectrolyte hydrogels based on n -alkyl methacrylate esters,acrylic acid and acrylamide cross-linked with 4,4′-diazobenzene were prepared.

合成了不同疏水链长的甲基丙烯酸酯、甲基丙烯酰胺及丙烯酸与 4 ，4′-二偶氮苯交联共聚的聚电解质凝胶。

Hydrogels based on n -alkyl methacrylate esters,acrylic acid and acrylamide cross-linked with 4,4′-diazobenzene were preparared.

合成了带不同疏水侧基的甲基丙烯酸酯、甲基丙烯酰胺及丙烯酸与 4，4′二偶氮苯交联共聚的凝胶。

Hydrogels based on n -alkyl methacrylate esters,acrylic acid and acrylamide cross-linked with 4,4′-diazobenzene were preparared,and their deswelling kinetics was studied.

研究了甲基丙烯酸十二烷或丁酯、甲基丙烯酰胺及丙烯酸与4 ，4′-二偶氮苯交联共聚凝胶的消溶胀动力学。

In a similar way, using N,N\'-dibenzyl tartamide as auxiliary,-(2-methyl)allyl-2-chloro-phenyl-methyl azide, a vital intermediate of Repaglinide, can be prepared via asymmetric allylation of o-chlorobenzaldehyde in

产物经氧化和碘加成内酯化反应得到阿伐他汀中间体(3R，5S)-3-羟基-5-碘甲基戊内酯(10)；将N-苄基酒石酸二酰胺用于邻氯苯甲醛的不对称烯丙基化反应以较高光学收率得-甲基烯丙基-2-氯苯基-甲基醇

This reaction was further extended to the coupling reaction of amide with diiodo biphenyl; and the carbazole derivatives were synthesized in 53%-95% yield.

另外将该反应体系的底物进行了进一步的拓展，用酰胺和二碘代联苯化合物偶联，合成了9个咔唑衍生物，收率在53％—95％之间，并运用~1H NMR、~(13)C NMR、HRMS等分析测试手段对这些化合物进行了表征。

Methods Sulfanilamide was injected by abdominal cavity and by gavage as the photosensitizer in mice and guinea pig, Then the ear thickness of mice was measured and the erythematic reaction of guinea pig was observed at 4 h, 24 h, 48 h after induced by UVA plus UVB or only UVA.

以对氨基苯磺酰胺作为光敏剂，经腹腔注射与灌胃两种途径对小鼠和豚鼠进行给药，通过UVA加UVB光照诱导以及只用UVA光照激发后，于4h、24h、48h和72h分别测量小鼠耳厚度及观察豚鼠皮肤红斑反应。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。