苯酰化

Starting from 3-benzoyl-5-formyl-indolizine, 3-benzoyl-5-(2'2'-diacetylethenyl)-indolizines and analogs were obtained by the 〓mediated aldol condensation or Wittig reaction. These compounds,promoted by low-valent titanium, gave highly functionlizedcycl[3,2,2]azine derivatives. The coupling reaction proceeded betweenthe carbonyl group and the carbon-carbon double bond, a rare example inMcMurry reaction.

我们以3-苯甲酰基-5-甲酰基中氮茚为原料，通过三碘化钐促进的aldol反应和Wittig反应制备了3-羰基-5-羰基乙烯基中氮茚，随后经低价钛还原偶联，没有生成正常的分子内羰基-羰基偶联产物，而是得到反常的羰基与α，β-不饱羰基的双键偶联产物，较高收率地得到了含多官能团的CycI[3，2，2]azine衍生物。

A series of 2-acetylformanilides were prepared,followed by thiolation with Lowesson reagent to afford 2-acetylthioformanilides,which further reacted with Mn3·2H2O in glacial acetic acid under microwave irradiation to afford 2-acetyl benzothiazole s.

合成了一系列的硫代酰胺，研究了它们在微波辐射醋酸锰作用下发生氧化自由基环化反应，成功地合成了一系列2-乙酰基苯并噻唑衍生物，其结构经红外光谱、核磁共振谱和质谱得到了证实

Methyl-2,3,5,6-tetrafluoro-benzene methanol was synthesized by chlorination, acylation, fluorination, esterifica- tion, reduction, bromization, reduction from terephthalic acid. Tefluthrin was obtained from-(1RS,3RS)-3-(2-chloro-3,3,3-trifluoro-1-propenyl)-2,2-dimethyl cycolpropa-necarboxylate acid by reacting with 4-methyl-2,3,5,6-tetrafluoro-benzene methanol.

以对苯二甲酸为原料，经氯化、酰氯化、氟化、酯化、还原、溴化、还原七步反应合成了4-甲基-2，3，5，6-四氟苄醇，甲基苄醇与-(1RS，3RS)-3-(2-氯-3，3，3-三氟丙-1-丙烯基)-2，2-二甲基环丙甲酸一步酯化合成了七氟菊酯。

We synthesized a new monomer 1, 4-bis (4-fluorobenzoyl) naphthalene(1, 4-BFN) using the acyl chloride reaction and Friedel-Crafts acylation reaction of 1, 4-Naphthalenedicarboxylic acid with fluorobenzene.

第二部分，我们从1，4-萘二甲酸出发，经过酰氯化反应及付氏酰基化反应，合成了新型单体1，4-二（4-氟苯羰基）萘(1， 4-BFN)。

Starting with commercial available tosylmethyl isocyanide and but-2-enoic methyl ester, pyrrolo[2,1-f][1,2,4]triazine derivatives was prepared by twelve-steps process in total yiled of 5.0%~8% via pyrrole and pyrrolo [2,1-f] [1,2,4] triazine ring formation, substitution and amination reactions etc.

本文以简单的对甲基苯磺酰甲基乙腈和反-2-丁烯酸为原料，经过形成吡咯，吡咯并[2，1-f][1，2，4] 三嗪环，取代，酰胺化等等12步反应，合成了结构新颖的吡咯并[2，1-f][1，2，4] 三嗪衍生物，总收率达5%～8%。

The intermediate which obtained from oximation of 7a-e reacted withmethyl N-(2-bromomethylphenyl)-N-methoxycarbamate to synthesize oxime ether methyl carbamate 3a-e.

以邻位卤代苯甲醛和3-丁烯-2-醇为原料通过钯催化&一锅法&反应合成了2-乙酰基茚7a-e，7a-e 肟化之后和N-(2-溴甲基苯基)-N-甲氧基氨基甲酸甲酯反应合成了肟醚类氨基甲酸甲酯3a-e，进一步胺解之后得到了肟醚类氨基甲酰甲胺3f-j。

The copolymer of N isopropylacrylamide and acrylamido azobenzene was synthesized for the study of the effect of the photoisomerization of a water soluble copolymer containing azobenzene groups on the photocontrolled release behavior of liposomes.

为了研究侧链含有偶氮苯基的水溶性共聚物的光异构化对脂质体内包容物的光控释放的影响，设计合成了N－异丙基丙烯酰胺和丙烯酰胺基偶氮苯的共聚物。

The synthetic route starts from penicillin G, peroxyacetic acid(8.5%) as Oxidizing Agent to get penicillin G sulfoxide; esterifided with p-nitrobenzyl bromine to synthesize penicillin G sulfoxide ester; we synthesize 3-exomethylenecepham sulfoxide ester with phthalimide potassium and 4A molecular sieve as acid scavenger to open the ring, SnCl_4 as catalyzation to close the ring. The yield is over 60%.

本研究采用的合成路线为：以青霉素G钾盐为原料，选用工业过氧化氢制备的过氧乙酸(22.3%)稀释至8.5%为氧化剂，氧化得青霉素亚砜；采用对硝基溴苄为酯化试剂，制备青霉素亚砜酯；以NCP(N-氯代邻苯二甲酰亚胺)为开环试剂，酞酰亚胺钾和4A型分子筛为酸清除剂，顺利开环；再经无水SnCl_4催化闭环得3-环外亚甲基头孢亚砜酯，最终产率在60%以上。

A new organic compound:N,N'-bis(1,10-phenanthroline-2-formacyl)-4,4'-diamino-diphenylmethane was synthesized via oxidation,esterification,substitution,hydrolysis, amidation of 1,10-phenanthroline as the starting material with chemical reagents (hydrogen peroxide,benzoyl chloride,potassium cyanide,sodium hydroxide solution,4,4'-diamino-diphenylmethane).

以邻菲啰啉为起始原料，与双氧水反应合成邻菲啰啉-N-氧化物，接着与苯甲酰氯、氰化钾、NaOH水溶液一一反应合成中间体邻菲啰啉-2-甲酸，再与4，4′-二氨基苯基甲烷进行酰胺化反应合成目标产物。

METHOD:Venlafaxine was synthesized by steps of etherification,acid chloridization,amidation,Grignard reaction,reduction,salifying from 4-hydrophenylacetic acid.

该化合物以对羟基苯乙酸为原料，经醚华、酰氯华、酰胺化格氏反应、还原、成盐等步骤制备而成。

The labia have now been sutured together almost completely.The drains and the Foley catheter come out at the top.

此刻阴唇已经几乎完全的缝在一起了，排除多余淤血体液的管子和Foley导管从顶端冒出来。

To get the business done, I suggest we split the difference in price.

为了做成这笔生意，我建议我们在价格上大家各让一半。