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These toxic data(TC50,SDH and LDH) were used as dependent variable and 10 topological indices of 25 aminobenzene derivatives were used as independent variable.QSAR was analyzed with multiple stepwise linear regression.The results indicated that there is different toxicity with different structure of compounds.

内容摘要以大鼠游离肝细胞半数中毒浓度(TC50)和细胞逸出酶为观察指标,研究了25种苯胺类化合物的肝细胞毒性,并利用这些毒性效应数据为因变量,以这些化合物的10种拓扑学指数为自变量,利用多元逐步回归统计分析方法进行了定量结构-活性关系的深入探讨。

These toxic data(TC50,SDH and LDH) were used as dependent variable and 10 topological indices of 25 aminobenzene derivatives were used as independent variable.QSAR was analyzed with multiple stepwise linear regression.The results indicated that there is different toxicity with different structure of compounds.

卫生毒理学杂志990108 内容摘要以大鼠游离肝细胞半数中毒浓度(TC50)和细胞逸出酶为观察指标,研究了25种苯胺类化合物的肝细胞毒性,并利用这些毒性效应数据为因变量,以这些化合物的10种拓扑学指数为自变量,利用多元逐步回归统计分析方法进行了定量结构-活性关系的深入探讨。

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