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Results: The accepting liquid concentration of benzocaine ointment containing 7% of LP was singnificant higher than that containing 1%, 3%, 5%, 10%, 13%, and 16%(P<0.01) by the analsis of variance.

结果:经方差分析,含7%azone的苯佐卡因软膏的接受液浓度明显高于含1%,3%,5%,10%,13%,16%azone的软膏(P<0.01);含azone和二甲基亚砜的混合透皮促进剂其接受液浓度明显高于单一的azone组(P<0.05)。

The method for synthesizing 2- benzofuran derivatives has easily available raw material, simple process, easy realization and high yield.

合成2位三氟甲基取代的苯并呋喃衍生物的方法,原料容易得到,合成工艺简单,易行,产率较高。

The absorption bands in visible region are related to photoinduced electron transfer processes, and the dimethylfluorenyl amino benzofuran groups are major chromophore thatcontributed to the sensitization of photo-to-current conversion.

可见区的吸收带都与光诱导电荷转移过程有关,二甲基芴氨基苯并呋喃基团是在光电转换敏化中起主要作用的基团。

The geometries,electronic structures,polarizabilities and hyperpolarizabilities,as well as the UV-Vis spectra of the two organic dye sensitizers containing bis-dimethylfluorenyl amino benzofuran were studied via density functional theory and time-dependent DFT.

运用密度泛函理论和含时密度泛函理论研究了两种含二-二甲基芴氨基苯并呋喃基团的有机染料敏化剂的几何结构、电子结构、极化率和超极化率以及紫外可见谱。

The optimal separating condition of chromatography analysis was: Shimadzu VP-ODS 150mm4.6mm as chromatographic column; acetonitrile/water (12/88,V/V, Contained 1.25mmol/l phosphoric acid) as mobile phase with flow rate of 1.0ml/min. Macroporous ion exchange resins and activated carbon were applied to enrich the trace level impurities and the main impurities was determined by LC-MS and GC-MS.They were : Benzonitrile , 2-Methyl-8-hydroxyquinoline, 2,6-Pyridinediamine , O-ethyloxime Cyclo-hexanone and compound with 220 molecular weight .

采用离子树脂和活性炭吸附富集这些微量的杂质,并通过液质联用和气质联用对杂质进行了定性分析,鉴定了影响290nm吸收的主要杂质为苯甲腈,2甲基-8羟基喹啉,2,6二氨基吡啶,O-乙基环己酮肟和分子量220的物质。

Hydroxy-2-methyl-1-phenyl propan-1-one (1173) was a more effective photoinitiator to these monomers than that of benzophenone.

与二苯甲酮相比,2-羟基-2-甲基-1-苯基丙酮(1173)对两种单体具有较好的引发效果。

The profile of liver CYP450 induction by DEX in male rat After 4 daily i.p. administering of 0,25, 50 and lOOmg/kg/d DEX in male Wistar rat, it was determined the total CYP450 content, the mRNA and protein expression levels of CYP3A1, CYP3A2 and CYP2B1/2, and the ERD (CYP3A catalytic activity), PROD (CYP2B catalytic activity) and BROD (total CYP450 catalytic activity) in livers.

DEX对雄性大鼠肝脏CYP450的诱导效应雄性Wistar大鼠腹注0、25、50和100mg DEX/kg/d诱导处理4天后,测定大鼠肝脏总CYP450含量,CYP3A1、CYP3A2和CYP2B1/2的mRNA及蛋白表达水平,肝脏红酶素脱甲基酶(ERD,CYP3A活性),苄氧基试卤灵脱乙基酶(PROD,CYP2B活性),苯氧基试卤灵脱乙基酶(BROD,总CYP450活性),结果表明,CYP450含量、ERD、PROD和BROD在DEX多次诱导后都有升高,CYP3A1 mRNA表达水平、蛋白含量和酶活性有明显的升高,剂量效应关系明显;CYP3A2蛋白也有明显升高,而其mRNA表达水平却没有变化,提示CYP3A1和CYP3A2的诱导机制可能不同。

The profile of liver CYP450 induction by DEX in male ratAfter 4 daily i.p. administering of 0,25, 50 and lOOmg/kg/d DEX in male Wistar rat, it was determined the total CYP450 content, the mRNA and protein expression levels of CYP3A1, CYP3A2 and CYP2B1/2, and the ERD (CYP3A catalytic activity), PROD (CYP2B catalytic activity) and BROD (total CYP450 catalytic activity) in livers.

DEX对雄性大鼠肝脏CYP450的诱导效应雄性Wistar大鼠腹注0、25、50和100mg DEX/kg/d诱导处理4天后,测定大鼠肝脏总CYP450含量,CYP3A1、CYP3A2和CYP2B1/2的mRNA及蛋白表达水平,肝脏红酶素脱甲基酶(ERD,CYP3A活性),苄氧基试卤灵脱乙基酶(PROD,CYP2B活性),苯氧基试卤灵脱乙基酶(BROD,总CYP450活性),结果表明,CYP450含量、ERD、PROD和BROD在DEX多次诱导后都有升高,CYP3A1 mRNA表达水平、蛋白含量和酶活性有明显的升高,剂量效应关系明显;CYP3A2蛋白也有明显升高,而其mRNA表达水平却没有变化,提示CYP3A1和CYP3A2的诱导机制可能不同。

Two kinds of haptens 6-{[(2,3-Dihydro-2,2-Dimethyl-7-benzofuranyloxy)carbonyl] -amino}hexanoicAcidand4-{[(2,3-Dihydro-2,2-Dimethyl-7-benzofuranyloxy) carbonyl]-amino}butanoic Acid has been synthesized by chemical way.

本研究以2,3-二氢-2,2-二甲基-7-苯并呋喃氯甲酸酯为基础合成了克百威的两种半抗原,6—

, propyl, butyl, 3-n-- now almost all skin and hair care products can be found in one or more of the above material.

甲基, 丙基,丁基,丁基苯-现在几乎所有的护肤和护发产品中,都可以找到一种或多种的上述物质。

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