苯并喹啉

The optimal separating condition of chromatography analysis was: Shimadzu VP-ODS 150mm4.6mm as chromatographic column; acetonitrile/water (12/88,V/V, Contained 1.25mmol/l phosphoric acid) as mobile phase with flow rate of 1.0ml/min. Macroporous ion exchange resins and activated carbon were applied to enrich the trace level impurities and the main impurities was determined by LC-MS and GC-MS.They were : Benzonitrile , 2-Methyl-8-hydroxyquinoline, 2,6-Pyridinediamine , O-ethyloxime Cyclo-hexanone and compound with 220 molecular weight .

采用离子树脂和活性炭吸附富集这些微量的杂质，并通过液质联用和气质联用对杂质进行了定性分析，鉴定了影响290nm吸收的主要杂质为苯甲腈，2甲基-8羟基喹啉，2，6二氨基吡啶，O-乙基环己酮肟和分子量220的物质。

Special attention was directed toward finding inhibitors selective against KDR tyrosine kinase in order to ensure that the in vivo profile of a specific Src inhibitor could be determined. The 4-aminobenzodioxole quinazoline series gave compounds with excellent potency and selectivity.

一直以来，人们为了确保能够在体内测定Src酶专属性抑制剂的特性，把研究焦点放在对KDR酪氨酸激酶选择性的抑制剂的寻找上。4-氨基苯并间二氧五环喹唑啉系列化合物具有极好的效力和选择性。

With L-DOPA as the starting chiral phenylalanine derivatives, construction of the skeleton of Phthalascidin was studied. Firstly, starting from L-DOPA and 3,4-dimethoxyphenylalanine, an amide 〓 was obtained, and a modeling cyclization reaction was carried out but failed to give the anticipated product.

二、对由苯丙氨酸甲酯衍生物通过Bischler-Napieralski反应合成四氢异喹啉—3—甲酯进行了研究，通过研究首次发现，生成苄基噁唑的反应是正常的B-N反应的竞争性反应，并从机理上给予了解释，所得出的结论具有一定的规律性，在杂环的合成方面具有一定的应用价值。

The thesis was mainly focused on the synthesis and synthetic methods ofimidazole, chromene, triazine, isoquinolin derivatives and divided into five sectionsbased on the contents.

中文摘要：论文对咪唑、苯并吡喃、三嗪和异喹啉类化合物的合成及其方法学进行了较系统的研究，依据其内容分为五个部分。

In this paper, the research and application progress on quinolines, benzimidazoles, and furazan etc deviatives of rosin were reviewed. The research foreground of rosin-based heterocyclic compounds were also forecasted.

本文对喹啉、苯并咪唑、呋咱等系列松香基杂环化合物的研究进展进行了综述，并对松香基杂环化合物的研究前景进行了展望。

AIM: To investigate the cardiac actions of 2--1 , 2, 3, 4-tetrahydro-6,7-dimethoxyl-l-[1'-(6''-methoxy-2''-naph-thalenyl ) ethyl ]-isoquinoline ( CPU57 ) by comparison with nifedipine and focus on its mechanism of actions.

目的：研究2--1，2，3，4-四氢-6，7-二甲氧基-1-[1′-(6&-甲氧-2&-萘)乙基]-异喹啉(CPU57)对心脏的作用并与硝苯地平进行比较，着重于其作用机制的研究。

Tetrahydrofolatecoenzyme,Benzimidazoline,One-carbontransfer,Mannichalkali,Tetrahydroisoquinoline,Tetrahydro-β-carboline

四氢叶酸辅酶，苯并咪唑烷，一碳转移，Mannich碱，四氢异喹啉，四氢-β-咔啉

The pyrrole, oxazoles, pyridinones, quinolines, dibenzodiazepines, tetrahydrobenzoxazines and tetronic acids have been prepared from enaminones.

吡咯、唑烷、嘧啶酮、喹啉、二苯并二氮杂环类、四氢苯并噁嗪酮和特窗酸等都可以由烯胺酮类化合物制得。

Methods: Eleven B-CLL patients were studied. Leukemic lymphocytes with (n=8) or without (n=3) P2z receptors were exposed in vitro to ATP, benzoylbenzoic-ATP, 2-methylthio-ATP(2MeSATP), adenosine-5′-［γ-thio］ triphosphate, and other nucleosides for 8h. Apoptosis was detected by electron microscopy, agarose gel electrophoresis, and quantitative TdT assay. Results:Apoptosis was detected only in leukemic lymphocytes with P2z receptors. By using the quantitative assay, ATP-inducing DNA strand breaks were found to occur specifically for BzATP, ATP and 2MeSATP, but not for ATP-γS and other nucleosides.

将表达P2z受体［P2z］与不含P2z受体［P2z］的两组CLL细胞分别同1.0mmol/L三磷酸腺苷体外培养8小时，以电镜、DNA凝胶电泳和定量DNA 3′端TdT法检测细胞凋亡；并对ATP、苯甲酰苯甲酸ATP、2-甲基硫ATP(2MeSATP)、γ-硫代ATP及其它核苷的诱导效应和氧化型ATP、1-［N，O-二(5-异喹啉碘酰基)N-甲基-L-酪氨酰］-4-苯哌嗪KN-62）的抑制效应做定量研究。

The HDS activity of Co-MoP/ Al_2O_3 catalysts is more effective than commercial catalysts and sulfured ones.

以二苯并噻吩和喹啉混合物为反应物，Co-MoP／γ-Al_2O_3具有较好的HDS活性。

Do you know, i need you to come back

你知道吗，我需要你回来

Yang yinshu、Wang xiangsheng、Li decang,The first discovery of haemaphysalis conicinna.

1〕 杨银书，王祥生，李德昌。安徽省首次发现嗜群血蜱。