苯并咪唑

Because they have one nitrogen atom with lone pair electrons, benzimidazole compounds are endowed with capability of complex and molecular recognition and they can analogue biological molecule.

苯并咪唑具有一个含孤对电子的氮原子，从而使苯并咪唑类化合物具有很强的配位能力及分子识别能力，可以用于生物分子的模拟。

Three new fluo-rine-containing nitro benzimidazole derivatives were synthesized in the presence of 4-dimethylaminepyridine andtheir structure and configuration were confirmed by elemental analysis, IR, and 1HNMR.

在碱性条件下由2-(4′-羟苯基)-5-取代苯并咪唑与氯乙酸作用得到5个新化合物取代苯并咪唑基苯氧乙酸。

Ethyl 4-[(1-hydroxy-1-methyl)ethyl]-2-propyl-1H-imidazole-5-carboxylate,the key intermediate of Olmesartan ,was synthesized from butanoic acid and o-phenylenediamine via condensation under microwave-irradiation,oxidation,esterification and the Gringard reaction.

用正丁酸与邻苯二胺为原料，在微波照射下缩合成2-丙基苯并咪唑，再氧化开环制得2-丙基咪唑二羧酸，再经酯化、Gringard反应制得抗高血压药物奥美沙坦的关键中间体2-丙基-4-[(1-羟基-1-甲基)乙基]-1H-咪唑-5-羧酸乙酯，总收率32.2%。

Finally, reacting II with PhNCO givethe compound 1-(6-nitrobenzimidazol-l-acetyl)-4-phenylsemicarbazide,III in the presence of〓 give the new cyclic compound 2-phenylamino-5-(6-nitrobenzimidazol- 1-methylene)-l,3,4-oxadiazole.

第三部分：以6-硝基苯并咪唑-1-乙酰肼为原料，分别与取代苯甲醛、苯乙酮及乙酰基二茂铁进行缩合反应，合成了10个新的6-硝基苯并咪唑-1-乙酰腙衍生物。

We firstly introduced benzoazole (including benzimidazole, benzoxazole and benzothiazole) into the meso-positions of porphines and obtained five new porphyrins 36a-e. Their structures were characterized by 1H NMR, MS, UV-vis spectra and fluorescence emission spectra.

将苯并唑类基团(苯并咪唑、苯并噁唑和苯并噻唑)引入到卟吩中位，得到5个新型卟啉36a-e衍生物，并经核磁氢谱、质谱、紫外吸收光谱和荧光发射光谱表征了化合物的结构。

Based on the problem of various types of catalyst and according to the features of carbonylation catalysts reactions, our team has been designed a series of new metal complexes of benimidazoles, which can be used for carbonylation catalyst of industry. Seven new benzimidazole derivatives were prepared by the o-phenylenediamine、oxalic acid、glycolic acid、monomethyl monopotassium malonate、ethyl cyanoacetate、succinic anhydride. The structures of them were confirmed by IR、Elemental analsis. The crystal structures of d and e were determined by X-ray single crystal diffraction of Germanic Bruker Smart APEX II CCD. The catalysis of them was tested by carbonylation reactions.

本文设计以邻苯二胺和草酸、羟基乙酸、丙二酸单甲酯、氰基乙酸乙酯、丁二酸单甲酯为原料采用PPA催化和无机酸催化法，合成了4种苯并咪唑-2-羧酸衍生物并进行了表征；培养了2个化合物d、e的晶体并测定和讨论了晶体结构；制备了3种未见报道的苯并咪唑金属配合物，对配合物在羰基化法制醋酐-醋酸反应的催化作用进行了初步试验。

Thirteen benzimidazole derivatives were synthesized by one-step oxidative cyclisation of 1, 2-phenylenediamine or 4-methyl-1, 2-phenylenediamine at room temperature and a series of aromatic aldehydes under imidazolium salt grafted iodobenzene diacetate assisted.

以水为溶剂，在咪唑盐二醋酸碘苯促进下，通过邻苯二胺或4-甲基邻苯二胺与各种芳醛室温氧化环合，一步合成了13种苯并咪唑类衍生物，反应时间25~45 min，反应产率92%~98%。

Methods Phenylacetaldehyde was prepared from benzimidazolium salt and benzyl chloride by the addition-hydrolysis reaction of benzimidazolium salt with Grignard reagent.

方法以苯并咪唑盐和苄基氯为原料，利用苯并咪唑盐与Grignard试剂的加成-水解反应合成苯乙醛。

By using 4-chloro-5-nitro phthalimide as raw material and through aminoysis, reduction, cyclization and hydrolysis, end-produce benzimidazole-5,6-diformic acid is prepared.

本发明公开了一种苯并咪唑－5，6－二甲酸的制备方法。该方法是以4－氯－5－硝基邻苯二甲酰亚胺为原料，依次经过氨解、还原、环合、水解反应过程，制得最终产品苯并咪唑－5，6－二甲酸。

Examples of metal chelating groups include hydroxides especially aryl or heteroaryl hydroxides such as phenolic hydroxides; amines which may be aliphatic aryl or heteroaryl; mercaptans which may be aliphatic aryl or heteroaryl; carboxylic acids which may be aliphatic aryl or heteroaryl; oximes and ketoximines; acetarylamides; hydroxy silanes and silicones; N-containing heterocycles such as imidazoles benzimidazoles triazoles benzotriazoles thiazoles isothiazoles acid anhydrides and more preferably acid groups (especially carboxylic acid groups phosphoric acid groups polyphosphoric acid groups phosphonic acid groups sulphuric acid groups and sulphonic acid groups).

金属螯合组的例子包括氢氧化物，特别是芳基或如酚醛氢氧化物杂氢氧化物；胺可能是脂肪族，芳基或杂；硫醇可能是脂肪族，芳基或杂，这可能是脂肪族，芳基或羧酸杂；肟和ketoximines； acetarylamides；羟基硅烷和有机硅，含N，如咪唑，苯并咪唑类，三唑类，苯并三氮唑，噻唑类，isothiazoles，酸酐杂环，多最好酸组（特别是羧酸团体，磷酸，团体，多聚酸组，膦酸组，硫酸团体和磺酸组）。

I didn't watch TV last night, because it .

昨晚我没有看电视，因为电视机坏了。

Since this year, in a lot of villages of Beijing, TV of elevator liquid crystal was removed.

今年以来，在北京的很多小区里，电梯液晶电视被撤了下来。