苯并吡喃

Experimental process: jing and 3- methyl -2- methyl ethyl ketonesynthesizes by the benzene zong; Again the glacial acetic acidcatalysis produces 2, 3, 3 - trimethyl - 3H - yinduo; Again has thealkylate response production yinduo iodide after the methyl iodide;The iodide takes off molecular HI under NaOH to become freejier thealkali; Adds 5 - nitryls salicylic aldehydes in the ethyl alcohol forthe solvent under if to respond finally produces 6 '- the nitryl yinduolin spiral benzene and pinan; Through the infrared spectrum andthe ultimate analysis irrevocably proved its structure, and studiedthe annulus with to open the annulus the light to send changes colorthe performance, explained in different solvent medium ultravioletabsorption spectrometry solvent effect, and the comparisondiscoloration the response speed number difference, finally mixed itadds to the methyl methacrylate, the peroxidation benzoin formyl in the plexiglass, tested 6 '- the nitryl yinduolin spiralbenzene and pinan in the glass fatigue resistance, thethermostability.

实验过程：由苯肼和3-甲基-2-丁酮合成腙；再冰醋酸催化生成2 ，3 ，3—三甲基—3H—吲哚；再经过碘甲烷发生烷基化反应生成吲哚碘化物；碘化物在NaOH下脱去一分子HI成为费歇尔碱；在乙醇为溶剂下加5－硝基水杨醛与其反应最后生成6'—硝基吲哚啉螺苯并吡喃；通过红外光谱和元素分析确证其结构，并研究了环体与开环体的光致变色性能，解释了在不同溶剂介质中紫外吸收光谱的溶剂效应，并比较褪色反应速率数的差异，最后将其掺加到甲基丙烯酸甲酯，过氧化二苯甲酰有机玻璃中，测试6'—硝基吲哚啉螺苯并吡喃在玻璃中的抗疲劳性、热稳定性。

Paper through to 6 '- nitryl yinduolin spiral benzene and pinan the synthesis, understands the spiral pinan color change.

论文通过对6'—硝基吲哚啉螺苯并吡喃的合成，来了解螺吡喃变色性。

The mechanism of the interaction between bovine serum albumin and pyrano [4,3-b] pyran derivative, 2-amino-7-methyl-4-(4-nitrophenyl)-5-oxo-4,5-dihydropyrano [4,3-b] pyran-3-carbonitrile, was studied by means of fluorescence spectroscopy under physiological conditions.

用荧光光谱法分析了在生理条件下一种吡喃并[4，3-b]吡喃衍生物-2-氨基-7-甲基-4-(4-硝基苯)-5-氧代-4H，5H-吡喃并[4，3-b]吡喃-3-腈与牛血清白蛋白的作用机制。

They are 4-(2- hydroxy-3-butynlenoxy) benzoic acid (1, WA), 5-chloro-7, 8-dihydroxy-7-methyl- 6-oxo-3- [ -3, 4-dihydroxy-3, 5-dimethyl-l-heptylene] -1H-8, 8a-dihydrobenzo [2, 3-c] pyran (2, WB),-2-(2-methyl-2-dibutene diamido)-2-butenoic acid (3, B5262), 3, 4-dihydro-9, 10-dihydroxy-7-methoxy-3-methyl-1H-naphtho [2, 3- c] pyran-1-one (4, A73 semi-Vioxanthin), 8, 8'-bis (6, 9-dioxo-3,4-dihydro-10- hydroxy-7-methoxy-3-methyl-1H-naphtho [2, 3-c] pyran-1-one)(5, A122 Xanthomegnin), 2, 5-dioxo-3a-hydroxymethyl-3, 3a, 6, 6a-tetrahydro-furo [2, 3-b] furan (6, 1003-2), 7-acety1-5-chloro-6, 8-dioxo-7-methyl-3- [ -3, 5-dimethyl-1, 3- diheptylene] -4aH-benzo [2, 3-c] pyran (7, M2-2 sclerotiorin), respectively.

它们分别被命名为4-（2-羟基-3-丁炔氧基）苯甲酸（1，WA）、5-氯-7，8-二羟基-7-甲基-6-氧代-3-[-3，4-二羟基-3，5-二甲基-1-庚烯基]-1H-8，8a-二氢苯并[2，3-c]吡喃（2，WB）、-2-（2-甲基-2-丁烯二酰亚胺基）-2-丁烯酸（3，B5262）、3，4-氢-9，10-二羟基-7-甲氧基-3-甲基-1H-萘并［2，3-c］吡喃-1-酮（semi-Vioxanthin，4，A73）、8，8'-双（6，9-二氧代-3，4-二氢-10-羟基-7-甲氧基-3-甲基-1H-萘并［2，3-c］吡喃-1-酮）（Xanthomegnin，5，A122）、2，5-二氧代-3a-羟甲基-3，3a，6，6a-四氢-呋喃并［2，3-b］呋喃（6，1003-2），7-乙酰基-5-氯-6，8-二氧代-7-甲基-3-［-3，5-二甲基-1，3-庚二烯基］-4aH-苯并2，3-c］吡喃（Sclerotiorin，7，M2-2）。

Quinone methides, generated in situ from the reaction of 4-hydroxycoumarin with benzaldehyde, formaldehyde and pentanal, underwent the Diels-Alder reaction with silyl enol ethers to give a series of 3,4-dihydro-2H,5H-pyrano[3,2-c][1]benzopyran derivatives in high yields.

通过4-羟基香豆素与苯甲醛、甲醛和戊醛缩合产生的quinone methide与烯醇硅醚的Diels-Alder反应，以较高产率合成了一系列含有硅氧基的3，4-二氢-2H，5H-吡喃并[3，2-c][1]苯并吡喃-5-酮衍生物。

Synthesis process Molecular Formula:〓 Molecular Weight: 394 Chemicla name: N-(2, 3-dihydro-2, 7-dimethyl-benzofuran-1-acyl)-N'-tert-butylN'-(3, 5-dimethyl benzoyl) hydrazine Structural formula:〓 This article define a synthesis method of JS118 with (2, 3-dihydro-2, 7-dimethylbenzofuranyl)-6-formic acid, tert-butyl hydrazine hydrochloride acid and 3, 5-dimethyl benzoic acid as main intermediate through four steps of reaction involving, acyl chloridation condensation and so on.

本文主要的研究工作内容：(1)以N-特丁基双酰肼为先导结构，利用分子等排原理和类同合成法进行先导设计，有目的、有选择地重点改变R〓、R〓基团，将具有不同取代基的苯环以及呋喃环、苯并呋喃环、吡咯环、吡啶环等杂环、稠杂环与先导结构进行有机的组合。

The thesis was mainly focused on the synthesis and synthetic methods ofimidazole, chromene, triazine, isoquinolin derivatives and divided into five sectionsbased on the contents.

中文摘要：论文对咪唑、苯并吡喃、三嗪和异喹啉类化合物的合成及其方法学进行了较系统的研究，依据其内容分为五个部分。

As we know, spiro-conjugated compound 1',3',3'-trimethyl-6-hydroxyspiro[2H-1-benzopyran-2,2'-indoline] is one of thesignificant photochromic species, the structure and spectrum ofthe compounds 1',3',3'-trimethyl-6- hydroxyspiro[2H-1-benzopyran-2,2'-indoline] and its isomers have studied.

三。研究了一类重要的光致变色物质之一螺旋共轭化合物1′，3′，3′-三甲基-6-羟基螺旋[2H-1-苯并吡喃-2，2'-二氢吲哚]及其光异构化产物的结构、光谱，并在此基础上，用完全态求和公式自编程序计算了非线性光学系数。

The experiment results indicated that the comprehensive interaction mode of Y with DNA might be that the dibenzofuran ring of Y intercalated into DNA base pairs and the benzene ring in side chain bind to DNA in the groove.

以曙红Y为模型化合物，实验表明可能Y中的二苯并吡喃环嵌入了DNA的碱基对之间，其侧链的苯环键合在DNA的沟槽中。

The ee's of30-93% and yields of 64-96% were achieved in NaClO / 4-PPNO and m-CPBA /NMO oxidant systems by using substituted styrenes and substituted2,2-dimethylchromenes as substrates.

在优化反应条件下，在NaClO／4-PPNO、m-CPBA／NMO两个氧化体系中，对取代苯乙烯系列底物获得了30～70％ee和64～96％的收率；对取代苯并吡喃类化合物，获得了84～93％ee和82～96％的收率。

But we don't care about Battlegrounds.

但我们并不在乎沙场中的显露。

Ah! don't mention it, the butcher's shop is a horror.

啊！不用提了。提到肉，真是糟透了。