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苯巴比妥

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A ratio spectra derivative spectrophotometry for simultaneous determination of quaternary mixture of aminopyrine, phenobarbital, caffeine and phenacetin was studied.

提出了可应用于四元混合体系同时测定的比光谱-导数分光光度法,阐述了该方法的基本原理,并将其应用于氨基比林、苯巴比妥、咖啡因和非那西丁四元混合体系中各组分的同时测定。

On the other hand, the hepatic microsomal aminopyrine demethylase activity was obviously inhibited 2 hours after administration of the same dose of SY-801 and SY-640, while the content of hepatic cytochrome P-450 was not affected.

体外实验表明,SY-801和SY-640对正常小鼠、3-甲基胆蒽(3-MC)处理小鼠及苯巴比妥处理小鼠小鼠肝微粒体氨基比林脱甲基酶活性都具有明显的抑制作用,其中对3-MC处理小鼠肝微粒体氨基比林脱甲基酶活性抑制作用最显著。

Mehtod: animals were given intraperitoneally normal saline(10ml/kg.d), phenobarbital (40mg/kg.d) and puerarin (100, 200mg/kg.d) respectively for seven days. Then the levels of hepatic microsomal CYP and cytochrome b5(Cytb5), and the activities of aniline hydroxylase and aminopyrine N-demethylase were determined by spectrophotography.

实验动物分别腹腔注射生理盐水、苯巴比妥(40mg/kg.d)、葛根素(100和200 mg/kg.d),给药7d后,用分光光度法测定肝微粒体CYP和细胞色素b5(Cytb5)的含量,以及苯胺羟化酶和氨基比林N-脱甲基酶的活性。

Mehtod: The animals were given intraperitoneally normal saline(10ml/kg.d), phenobarbital (40mg/kg.d) and puerarin (100, 200mg/kg.d) respectively for seven days. Then the levels of hepatic microsomal CYP and cytochrome b5(Cytb5), and the activities of aniline hydroxylase and aminopyrine N-demethylase were determined by spectrophotography.

实验动物分别腹腔注射生理盐水、苯巴比妥(40mg/kg.d)、葛根素(100和200 mg/kg.d),给药7d后,用分光光度法测定肝微粒体CYP和细胞色素b5(Cytb5)的含量,以及苯胺羟化酶和氨基比林N-脱甲基酶的活性。

Methods:Phenobarbital and Valproic acid were added into astrocytes and cultured permanently for 30 days. P-glycoprotein, a product of MDR1, was detected with immunocyto chemistry. Then, 5μg/ml Sibelium was added to resistance cells and nonresistance cells, MTT assay was used to measure reverse multiple and relative reverse efficiency rate.

苯巴比妥钠和丙戊酸钠分别加入培养的星形胶质细胞内,30天后用免疫细胞化学法检测MDR1的表达产物P-糖蛋白,继之将终浓度为5μg/ml的西比灵分别加入培养的正常细胞及MDR1表达增强的细胞内,用四甲基偶氮唑盐法计算逆转倍数和相对逆转效率,了解西比灵逆转MDR1表达的作用。

SCE on second order differential oscillogram, and the height of this pair peak of β-CD on the oscillogram decreased with the increase of Cu(superscript 2+) or rutin, phenobarbital, L-plenylalanine and amantadine hydrochloride concentration.

SCE处产生一对可逆、灵敏的峰,当加入Cu(上标 2+)、芦丁、苯巴比妥、L-苯丙氨酸、盐酸金刚烷胺等金属离子或有机物时,β-CD的二次微分示波图上的峰高降低。

Drugs (methimazole, methylthiouracil, propylthiouracil and thiouracil); some sedatives (doxylamine succinate and phenobarbital); and some other drugs including the systemic antifungal antibiotic griseofulvin, the diuretic spironolactone, and the antibacterial sulfa drugs sulfamethazine and sulfamethoxazole.

抗甲状腺?药物(他巴唑,甲基硫氧嘧啶,丙基硫氧和硫氧嘧啶);一些镇静剂(doxylamine琥珀和苯巴比妥),以及包括系统性真菌抗生素灰黄霉素,安体舒通的利尿一些其他药物,以及抗菌磺胺类药物和磺胺二甲嘧啶。

For example, an uncomplicated urinary tract infection may be cured with a sulfonamide, whereas a patient with grand mal epilepsy may have to be treated for life with phenytoin or phenobarbital or both.

例如,无并发症的尿道感染用一种磺胺药物治疗10天就可能痊愈,而患有大发作的癫痫病人则须用苯妥英钠或苯巴比妥或两药合用作终身治疗。

Of sedatives such as phenobarbital, amytal, such as the milk through the plasma barrier, the liver in infants have higher brain concentrations, long-term medication discontinuation, when the baby may be drug reaction, the performance of unstable, disturbed sleep from time to time, and jitter, such as excessive crying.

镇静药中如苯巴比妥、阿米妥等通过血浆乳汁屏障后,在婴儿肝脏有脑内浓度较高,长期用药时一旦停药则婴儿可出现停药反应,表现不安定、睡眠时有惊扰、过多啼哭及抖动等。

METHODS: The serum concentration of valproic acid、diphenylhydantoin、carbamazepine、phenobarbital by HPLC.

采用高效液相色谱法(High performance liquid chromatography ,HPLC)测定丙戊酸、苯妥英钠、卡马西平、苯巴比妥的血药浓度785例,并对结果进行分析。

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