苯基丙醛

Dimethicone ,Cyclopentasiloxane,Dimethicone/Vinyl Dimethicone Crosspolymer,Polysilicone-11,Glycoproteins,Panax Ginseng Root Extract,Equisetum Arvense Extract,Silica Dimethyl Silylate ,Bisabolol,Tocopheryl Acetate ,Sodium Hyaluronate,Ursolic Acid,Atelocollagen,Sodium Chondroitin Sulfate,Ethylhexyl Methoxycinnamate,Polyglyceryl-2 Tetraisostearate ,Glycerin ,Water,Alcohol,Butylene Glycol ,Lecithin,Xanthan Gum ,Mica,Fragrance ,Benzyl Alcohol,Linalool ,Hydroxycitronellal,Alpha-Isomethyl Ionone ,Amyl Cinnamal,Hexyl Cinnamal,Palm Tree Extract,Geraniol,Benzyl Benzoate,Butylphenyl Methylpropional,Phenoxyethanol,Methylparaben,Isopropylparaben,Butylparaben ,Isobutyl Paraben,Titanium Dioxide,Carmine

地美司康，环戊硅氧烷，聚二甲基硅氧烷/乙烯基聚二甲硅氧烷交联聚合物，聚硅氧烷-11，糖蛋白，人参根萃取，问荆萃取，二甲基甲硅烷基化硅石，没药醇，醋酸盐维他命E，透明质酸钠，熊果酸，去端肽胶原，硫酸盐软骨素，4-甲氧基肉桂酸-2-乙基己基酯，聚甘油-2 四异硬脂酸酯，甘油，水，酒精，丁二醇，卵磷脂，山羊胶，云母，香料，苯甲醇，沉香醇，羟基香茅醛，α异甲基紫罗酮，戊基肉桂醛，己基肉桂醛，棕榈树萃取，香叶醇，苯甲酸苯甲酯，丁苯基甲基丙醛，苯氧乙醇，羟苯甲酯，羟苯丙酯，羟苯丁酯，二氧化钛，胭脂虫红

The auxiliary can be recovered in high yield (81%) only by filtering and recrystallization. Besides, some other aldehydes have been chosen to test the enantioselectivity of N,N\'-dibenzyl tartamide, in comparison with two other allylaborates reagents developed previously by Roush and Brown, respectively. The results show that %e.e. of homoallylic alcohol is superior to that of the former, and approaches the Brown reagent.

产物经S_N2反应得瑞格列萘中间体-甲基烯丙基-2-氯苯基-叠氮甲烷(17)；同时，将筛选出的新型手性配体N-苄基酒石酸二酰胺用于其他几种醛(正丁醛，异戊醛和环己醛)的不对称烯丙基化反应，并与广泛应用的Roush配体(22)和Brown配体(27)相比较，发现其立体选择性优于Roush配体，并接近Brown配体，但明显具有可回收利用的优势。

Aqua, Sorbitol, PPG-1 PEG-9 Lauryl glycol ether, Hydrolyzed elastin, Hydrolyzed wheat gluten, Hydrolyzed collagen, Hydrolyzed glycosamino-glycans, Humulus lupulus, Propylene glycol, Triethanolamine, Sodium hydroxide, Carbomer, Maris limus extract, Ostrea extract, Imidazolidinyl urea, Parfum, Benzyl salicylate, Coumarin, Alpha isomethyl ionone, Hexyl cinnamal, Buthylphenylmethylpropionate, Linalol, Methylisothiazolinone, Methylchloroisothiazolinone.

水，山梨醇， PPG 公司- 1聚乙二醇- 9十二烷基醇醚，水解弹性蛋白，水解小麦面筋蛋白，水解胶原蛋白水解粘多糖，多聚糖，啤酒花提取物花，丙二醇，三乙醇胺，氢氧化钠，卡波姆，马里斯提取物，牡蛎提取物，咪唑烷基脲，香水，水杨酸苄酯，香豆素，阿尔法 l 紫罗兰酮，己基肉桂醛，丁苯基甲基丙醛，芳樟醇，甲基异噻唑啉酮，甲基氯异塞唑晽酮。

This work, concentrated on the asymmetric allylation of aldehydes controlled by different chiral auxiliaries prepared from rotational pure tartaric acid, can be divided into three parts.The first part aims to review the developments of chiral drugs and asymmetric synthesis, from which derived the present research topic backgrounds and works.Synthesis and applications of allylation from aldehydes are the second part of the thesis. By optimizing the reaction conditions, such as solvents, temperature, time and chiral auxiliaries like N,N\'-dibenzyl tartamide, N,N\'-p-dimethylphenyl tartamide, N,N\'-o-dimethylphenyl tartamide, N,N\'-o-dichlorophenyl tartamide, N,N\'-a-dinaphyl tartamide, N,N\'-dicyclohexyl tartamide and N,N\'-diphenyl tartamide, ideal experimenttal conditions are obtained according to HPLC monitoring, as well as the auxiliaries\' recoveries experiments. Starting from benzaldehyde and 3-bromopropaldehyde, N,N\'-dibenzyl tartamide is considered the best auxiliary in this reaction.

本文介绍了醛的不对称烯丙基化反应，以光学纯酒石酸为原料，研究了不同构型手性配体在醛的烯丙基化反应中的立体选择性，全文共分三部分十个章节：第一部分对当前手性药物和手性技术进行了概述，并由此展开了本文的研究背景和任务；第二部分为有机合成部分，对醛的不对称烯丙基化反应进行了深入探讨，以苯甲醛为原料对反应条件进行优化，在优化的反应条件下对制备的七种可回收手性酰胺配体(N-苄基酒石酸二酰胺、N-对甲苯基酒石酸二酰胺、N-邻甲苯基酒石酸二酰胺、N-邻氯苯基酒石酸二酰胺、N-a-萘基酒石酸二酰胺、N-环己基酒石酸二酰胺和N-苯基酒石酸二酰胺)进行筛选，优化配体回收实验条件，最终确定出N-苄基酒石酸二酰胺在苯甲醛的不对称烯丙基化反应中具有较大优越性，结晶回收的手性配体光学纯度保持不变。

Promoted by metal dysprosium, aldehydes and ketones could react smoothly with propargyl bromide to afford the corresponding homopropargylic alcohols in good to excellent yields, and no allenic alcohol s were found.

当用苯基炔丙基溴代替炔丙基溴与醛、酮反应时，主要得到了相应的连二烯醇，而没有发现高快丙醇的存在，由此提出了六元环过渡态的反应机理

Then, it was condensed with-valine methyl ester to form a chiral imine, which was reacted with allyl zinc bromide in the presence of CeCl3·7H2O to afford the corresponding chiral homoallylic amine with high optical activity.

-N-Boc-3-苯基-2-氨基丙醛与-缬氨基酸甲酯缩合生成手性亚胺，在七水合三氯化铈（CeC13·7H2O）催化以及底物的手性诱导作用下，该手性亚胺与烯丙基溴化锌经不对称加成反应合成了高光活性的单烯丙基化手性胺。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。