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The study indicated that, with SnCl22H2O and TSA as the catalyst, the comparatively appropriate reaction conditions were as follows: the catalyst content was 0.5% to OLLA, polymerized at 180℃ for lob under a system vacuum of 0.98 MPa.

研究表明,较为适宜的工艺条件为:以二水合氯化亚锡(SnCl22H2O)和对甲基苯磺酸为催化剂,且SnCl22H2O相对于乳酸预聚体的质量比为0.5%,真空度-0.98MPa,温度180℃,反应时间10h。

These ingredients includes epidermal growth factor, hepatocyte growth factor, dimethyl sulfoxide, phenobarbital sodium and all trans-retinoic acid. We isolate and culture primary 10-weeks-old human fetal hepatocytes, observe hepatocytes form and its function markers. Inoculate hepatocytes with HBV Dane particles to observe if HBV susceptibility of fetal hepatocytes can be induced in vitro. To detect HBV covalently closed circular DNA within hepatocytes, we improve the existent PCR method.

基于上述假设,我们设计了10种培养条件,在自行设计的无血清培养基中添加不同的细胞分化诱导物,包括表皮生长因子、肝细胞生长因子、二甲基亚砜、苯巴比妥钠、全反式维甲酸等,分离孕10周龄人胎肝细胞进行原代培养,观测肝细胞形态及功能指标变化,并定时给予HBV感染,观察能否在体外诱导胎肝细胞出现HBV易感性;为检测肝细胞内HBV共价闭合环状DNA(covalently closed circular DNA,cccDNA),我们改进了现有的PCR检测法。

Effective over-the-counter acne treatments include topical salves and creams that contain benzoyl peroxide, or a five-percent solution of tea tree oil, or dimethylsulfoxide.

有效过分了柜台痤疮的治疗方法包括专题salves和面霜含有过氧化苯甲酰,还是5个百分点,解茶树油,或二甲基亚砜。

Methods: Analyses are based on the adolescent a subsample (ages 12-17, N=19430), of a nationally representative community survey.

目的 :评价美国青少年中 Ecstasy ( 3,4-亚甲二氧基甲基苯丙胺, MDMA ,即"摇头丸")使用与心理障碍的共病形式,调查个体、家庭和社区水平的相关危险和预防因素。

In order to achieve a rapid and accurate selection for extractive distillation solvent, and to acquire 1,2,3-trimethylbenzene with high purity from solvent oil via extractive distillation, the UNIFAC model was used to calculate the relative volatility of 1,2,3-trimethylbenzene to indane (the mass ratio of 1,2,3-trimethylbenzene to indane is 4∶1) in five different solvents, acetophenone, di-2-octylhexyl phthalate, glycol, dimethyl sulfoxide,sulfolane at 17.47 kPa.

为了快速准确地选择萃取精馏溶剂,由190#溶剂油萃取精馏获取高纯度连三甲苯,运用UNIFAC模型,计算了质量比为4∶1的连三甲苯-茚满体系在苯乙酮、乙二醇、邻苯二甲酸二辛酯、二甲基亚砜和环丁砜5种溶剂中在17.47 kPa下的相对挥发度。

The cis-decalin 79 was obtained from 2-methoxy-4-methylphenol (77) via a sequence of reactions involving intermolecular Diels-Alder reaction of masked o-benzoquinone derived from 77 and ethyl vinyl ketone, silyl enol ether formation and Cope rearrangement.

第一部份:以2-甲氧基-4-甲基酚(77)为起始物,经由二乙醯基亚碘苯氧化、分子间Diels-Alder反应、烯醇矽醚的形成及Cope重排反应得到具有十氢萘骨架化合物79。

The composite stabilizer of chlorinated paraffin was made from ethylene glycol diglycidyl ether, methyl stannic, triphenyl phosphate, exoxidized soybean oil. The influences of components in the composite stabilizer for thermal stability of chlorinated paraffin were investigated.

以乙二醇二缩水甘油醚和甲基锡为主稳定剂、亚磷酸三苯酯和环氧大豆油为助稳定剂制备了氯化石蜡复合稳定剂,研究了各组分配比对氯化石蜡热稳定性的影响。

The invention provides a foliar fertilizer specially used for Chinese gooseberries, which has the functions of cold resistance and consists of the following raw materials according to weight percentage: 0.1 to 8 percent of DMSO, 0.05 to 5 percent of trimethylene glycol, 0.05 to 5 percent of salicylic acid, 0.05 to 2 percent of compound ammonium nitrate, 1 to 15 percent of humic acid, 0.5 to 10 percent of chitosan, 1 to 10 percent of citric acid, 2 to 15 percent of urea, 1 to 10 percent of borax, 1 to 20 percent of zinc sulfate, 0.5 to 10 percent of ferrous sulfate, 0.05 to 5 percent of ammonium molybdate, 1 to 15 percent of manganese sulfate, 0.1 to 2 percent of SDBS and 35 to 80 percent of water.

本发明提供一种具有抗寒作用的猕猴桃专用叶面肥,它由下述各组分重量百分比的原料组成:二甲基亚砜0.1%~8%、丙二醇0.05%~5%、水杨酸0.05%~5%、复硝铵0.05%~2%、腐殖酸1%~15%、壳聚糖0.5%~10%、柠檬酸1%~10%、尿素2%~15%、硼砂1%~10%、硫酸锌1%~20%、硫酸亚铁0.5%~10%、钼酸铵0.05%~5%、硫酸锰1%~15%、十二烷基苯磺酸钠 0.1%~2%、水35%~80%。

UV spectra of the n -octanol gels formed by the three gelators indicate that the K bands of benzene rings are red shifted. It reveals that the π-π stack is one of the driving forces for the self-assembly of the gelators. The extent of red shifts of K bands depends on the amount of methyl groups in benzene rings which is in accord with the stabilities of the gels formed by such three gelators.

紫外吸收光谱表明,对比其溶液态,三种衍生物聚集体苯环的K带发生红移,表明π-π堆积作用是亚苄基山梨醇衍生物凝胶剂自组装的驱动力之一;红移的幅度随苯环上甲基数量的增加而增加,这与三种衍生物形成的分子凝胶的热稳定性相吻合。

The effects and mechanism of GABAergic neurons, NOergic neurons, opioid peptide and cyclic adenosine monophosphate in the nucleus reticularis thalami on sleep-wakefulness cycle of rats and the effects and mechanism of the 5-HTergic nerve fibers project from the nucleus raphes dorsalis to RT on sleep-wakefulness cycle of rats were investigated with the methods of brain stereotaxic, nucleus spile, microinjection and polysomngraphy.1. The effects of GABAergic neurons in RT on sleep-wakefulness cycle of rats1.1 Microinjection of 3-mercaptopropionic acid (3-MP, a kind of glutamate decarboxylase inhibitor) into RT. On the day of microinjection, sleep only decreased a litter. On the second day, sleep marked decreased and wakefulness marked increased. On the third and fourth day, sleep and wakefulness stages resumed to normal.1.2 Microinjection of gamma-amino butyric acid (GABA 1.0μg) into RT enhanced sleep and reduced wakefulness compared with control; while microinjection of L-glutamate (L-Glu, 0.2μg) decreased sleep and increased wakefulness; microinjection of bicuculline (BIC, 1.0μg), a GABAA receptor antagonist, enhanced wakefulness and reduced sleep; microinjection of baclofen (BAC, 1.0μg), GABAB receptor agonist, had the same effects as GABA.2. The effects of NOergic neurons in RT on sleep-wakefulness cycle of rats2.1 Microinjection of L-arginine (L-Arg, 0.5μg) into RT decreased sleep compared with control, but there were on statistaical difference between L-Arg group and control; while microinjection of sodium nitroprusside (SNP, 0.2μg), a NO donor into RT, sleep marked decreased and wakefulness marked increased. Microinjection of nitric oxide synthase inhibitor, N-nitro-L-arginine (L-NNA, 2.0μg) into RT enhanced sleep and reduced wakefulness.2.2 After simultaneous microinjection of L-NNA (2.0μg) and SNP (0.2μg) into RT, SNP abolished the sleep-promoting effect of L-NNA compared with L-NNA group; after simultaneous microinjection of L-NNA (2.0μg) and L-Arg(0.5μg) into RT, we found that L-NNA could not blocked the wakefulness-promoting effect of L-Arg.3. The effects of opioid peptide in RT on sleep-wakefulness cycle of rats3.1 Microinjection of morphine sulfate (MOR, 1.0μg) into RT increased wakefulness and decreased sleep compared with control; while microinjection of naloxone hydrochloride (NAL, 1.0μg), the antagonist of opiate receptors, into RT, enhanced sleep and reduced wakefulness.3.2 After simultaneous microinjection of MOR (1.0μg) and NAL (1.0μg) into RT, the wakefulness-promoting effect of MOR and the sleep-promoting effect of NAL were not observed compared with control.4. The effects of cAMP in RT on sleep-wakefulness cycle of rats Microinjection of cAMP (1.0μg) into RT increased sleep and decreased wakefulness compared with control; microinjection of methylene blue (MB,1.0μg) into RT enhanced sleep and reduced wakefulness compared with control.5. The effects of the 5-HTergic nerve fibers project from DRN to RT on sleep-wakefulness cycle of rats5.1 When L-Glu (0.2μg) was microinjected into DRN and normal sodium (NS,1.0μg) was microinjected into bilateral RT. We found that sleep was decreased and wakefulness was increased compared with control; when L-Glu (0.2μg) was microinjected into DRN and methysergide (MS,1.0μg), a non-selective 5-HT antagonist, was microinjected into bilateral RT, We found that sleep was enhanced and wakefulness was reduced compared with L-Glu group.5.2 When p-chlorophenylalanine (PCPA, 10μg) was microinjected into DRN and NS (1.0μg) was microinjected into bilateral RT, We found that sleep was increased and wakefulness was decreased compared with control; microinjection of 5-hydroxytryptaphan (5-HTP, 1.0μg), which can convert to 5-HT by the enzyme tryptophane hydroxylase and enhance 5-HT into bilateral RT, could block the effect of microinjection of PCPA into DRN on sleep-wakefulness cycle.

本研究采用脑立体定位、核团插管、微量注射、多导睡眠描记等方法,研究丘脑网状核(nucleus reticularis thalami,RT)中γ-氨基丁酸(gamma-amino butyric acid ,GABA)能神经元、一氧化氮(nitrogen monoxidum,NO)能神经元、阿片肽类神经递质、环一磷酸腺苷(cyclic adenosine monophosphate,cAMP)及中缝背核(nucleus raphes dorsalis,DRN)至RT的5-羟色胺(5-hydroxytryptamine,5-HT)能神经纤维投射对大鼠睡眠-觉醒周期的影响及其作用机制。1 RT内GABA能神经元对大鼠睡眠-觉醒周期的影响1.1大鼠RT内微量注射GABA合成关键酶抑制剂3-巯基丙酸(3-MP,5μg),注射当天睡眠时间略有减少,第二日睡眠时间显著减少,觉醒时间明显增多,第三、四日睡眠和觉醒时间逐渐恢复至正常。1.2大鼠RT内微量注射GABA受体激动剂GABA( 1.0μg)后,与生理盐水组比较,睡眠时间增加,觉醒时间减少;而RT内微量注射L-谷氨酸(glutamic acid, L-Glu, 0.2μg)后,睡眠时间减少,觉醒时间增加;RT内微量注射GABAA受体阻断剂荷包牡丹碱(bicuculline,BIC,1.0μg)后,睡眠时间减少,觉醒时间增加;RT内微量注射GABAB受体激动剂氯苯氨丁酸(baclofen,BAC,1.0μg)后,产生了与GABA相似的促睡眠效果。2 RT内NO能神经元对大鼠睡眠-觉醒周期的影响2.1大鼠RT内微量注射NO的前体L-精氨酸(L-Arg,0.5μg)后,与生理盐水组对比,睡眠时间略有减少,但无显著性意义;而RT内微量注射NO的供体硝普钠(Sodium Nitroprusside,SNP,0.2μg)后可明显增加觉醒时间,缩短睡眠时间;微量注射一氧化氮合酶抑制剂L-硝基精氨酸(L-arginine,L-NNA,2.0μg)后,引起睡眠时间增多,觉醒时间减少。2.2大鼠RT内同时微量注射L-NNA(2.0μg)和SNP(0.2μg)后与L-NNA组比较发现SNP逆转了L-NNA的促睡眠作用;RT内同时微量注射L-NNA(2.0μg)和L-Arg(0.5μg)后,与L-NNA(2.0μg)组比较发现L-Arg可以增加觉醒而缩短睡眠,其促觉醒作用未能被NOS的抑制剂L-NNA所逆转。3 RT内阿片肽对大鼠睡眠-觉醒周期的影响3.1大鼠RT内微量注射硫酸吗啡(morphine sulfate,MOR,1.0μg)后与生理盐水组对比,睡眠时间减少而觉醒时间增加; RT内微量注射阿片肽受体拮抗剂盐酸纳洛酮(naloxone hydrochloride,NAL,1.0μg)后与生理盐水组比较,睡眠时间增加而觉醒时间减少。3.2大鼠RT内同时微量注射MOR(1.0μg)和NAL(1.0μg)后,与生理盐水组对比,原有的MOR促觉醒效果和NAL的促睡眠效果都没有表现。4 RT内环一磷酸腺苷信使对大鼠睡眠-觉醒周期的影响大鼠RT内微量注射cAMP(1.0μg)后与NS(1.0μg)组比较,睡眠时间增多而觉醒时间减少;RT内微量注射亚甲蓝(methylene blue,MB,1.0μg)后,与NS组比较,睡眠时间增多而觉醒时间减少。5中缝背核投射到丘脑网状核的5-羟色胺能神经纤维对大鼠睡眠-觉醒周期的影响5.1大鼠DRN内微量注射L-Glu(0.2μg),同时在双侧RT内微量注射NS (1.0μg)后,与对照组(DRN和双侧RT注射NS, 0.2μg)比较,睡眠时间减少,觉醒时间增多;大鼠DRN内微量注射L-Glu(0.2μg),同时在双侧RT内微量注射二甲基麦角新碱(methysergide, MS, 1.0μg )后,与对照组(DRN注射L-Glu 0.2μg,双侧RT注射NS 1.0μg)比较,睡眠时间增多,觉醒时间减少。5.2大鼠DRN内微量注射对氯苯丙氨酸(p-chlorophenylalanine,PCPA,10μg),同时在双侧RT内微量注射NS (1.0μg)后,与对照组(DRN和双侧RT注射NS, 1.0μg)比较,睡眠时间增多,觉醒时间减少;大鼠DRN内微量注射PCPA(10μg),产生睡眠增多效应后,在双侧RT内微量注射5-羟色胺酸(5-hydroxytryptaphan , 5-HTP, 1.0μg )后,与对照组(DRN注射PCPA 10μg,双侧RT注射NS 1.0μg)比较,睡眠时间减少,觉醒时间增多。

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Now, however, all children continue in "comprehensive" schools, and the eleven-plus determines which courses of study the child will follow.

然而现在,所有的孩子都要在综合学校继续学习,所以这次考试只是决定他们将要学习哪些课程。

Cultivatable land , and led to a general recognition that development must not be carried at the cost of agriculture .

城区的迅速扩大在很多情况下侵占了宝贵的可耕地,使人们普遍认识到发展不能以牺牲农业为代价。

Detailed Intrinsic Reaction Coordination calculations were carried out to guarantee the optimized transition-state structures being connected to the related tautomers.

同时,做了详尽的内禀反应坐标计算,以保证所得到的过渡态连接相应的始末异构体。