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苄青霉素

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I thought Bicillin is a mix with both Penicillin G Benzedrine and PenicillinG Procaine, I was wrong, right?

我以为Bicillin是苄星青霉素G和普鲁卡因青霉素的混合,我是不是错了?

The resistance the isolated strains to chloromycetin and erythromycin were significantly increased, and that to vancomycin, penicillin, ampicillin, gentamicin, nitrofurantoin and levofloxacin were not varied markedly.

而对万古霉素、青霉素、氨苄西林、庆大霉素、呋喃妥因、左氧氟沙星的耐药性无明显改变。结论 10年后肠球菌的耐药性发生了变化,对一些抗生素的耐药率均有增升。

Results: The proportion of Gram-negative bacilli rose obviously, so did the opportunistic pathogen's and Yeasts detected rate. Most drug sensitive tests showed the drug-fast rate turned to be high. Escherichia coli, Salmonella and Citrobacter resistant and so on to fluoroquinolones was 57%~97%. These bacteria to imipenem showed excellent activity. Meticillin-resistant-staphylococcus resistant to ciprofloxacin, norfloxacin, clindamycin, tetracycline, erythromycin, cefazolin and ampicillin were 40.9%, 42.4%, 63.6%, 72.2%, 85.9%, 100.0% and 100.0%, respectively Streptococcus and Enterococcus resistant to major β-lactams-penicillin, aminoglycosides, macrolides, tetracyclines and sulfonamides were between 36.0% to 100.0%.

结果:革兰阴性杆菌比例显著升高,条件致病菌和酵母样真菌检出机会显著增多;药敏结果显示多数临床细菌对常用抗生素的耐药趋势在不断上升;大肠埃希菌、沙门菌和枸橼酸杆菌等革兰阴性杆菌对喹诺酮类药物的耐药率达57%~97%,亚胺培南则对阴性杆菌有较高的敏感覆盖率;耐甲氧西林葡萄球菌对环丙沙星、诺氟沙星、氯洁霉素、四环素、红霉素、头孢唑啉和氨苄西林的耐药率分别为40.9%、42.4%、63.6%、70.2%、85.9%、100.0%和100.0%;链球菌和肠球菌对多数β内酰胺类青霉素、氨基糖苷类、大环内酯类、四环素类以及磺胺类药物均呈高度耐药,耐药率在36%~100%。

In a system consisting of 20% PEG 400 and 12% magnesium sulfate, the partition coefficient of PGA was less than 0.01, PGA almost completely partitioned into the magnesium sulfate-rich bottom phase. Meanwhile, the partition coefficient of cephalexin was 6.7, the partition coefficients of phenylglycine methyl ester and 7-ADCA were 1.5 and 1.2, respectively.

通过考察头孢氨苄、苯甘氨酸甲酯和7-氨基脱乙酰氧基头孢烷酸(7-ADCA)在ATPS中的分配行为建立了一个含20%PEG 400和12%硫酸镁的ATPS,在此体系中头孢氨苄的分配系数为6.7,苯甘氨酸甲酯的分配系数为1.5,7-ADCA的分配系数为1.2,且青霉素酰化酶的分配系数小於0.01。

objective: the clinical date of 60 cases of early syphilis were analyzed.and summed up with the morbid condition ,types of tetter and therapeutic effect.method:all patients were divided into four groups and offered benzathine benzylpenicillin,ceftriaxone, tetracycline and azithromycin respectively.result: the cure risks of the groups treated with benzathine benzylpenicillin or ceftriaxone were all 100 percent, and no repellency in serum of the patients treated with ceftriaxone, the cure risks of the groups treated with tetracycline or azithromycin were all 80 percent.conclusion : it is indicated that benzathine benzylpenicillin and ceftriaxone were all of the best effective drugs.

目的:对60例早期梅毒患者发病情况、皮疹类型、治疗效果进行临床分析和总结。方法:分别采用苄星青霉素、头孢曲松、四环素及阿奇霉素治疗。结果:苄星青霉素、头孢曲松组,临床治愈100%,头孢曲松组无血清学抵抗,四环素、阿奇霉素临床治愈80%。

Heated in a boiling water bath, penicillin antibiotics such as amoxicillin, ampicillin, sodium cloxacillin, sodium carbenicillin and sodium benzylpenicillin could react with K3[Fe6] to form combined products in a dilute HCl medium. As a result, resonance Rayleigh scattering intensity was enhanced greatly and new RRS spectra appeared. The maximum scattering wavelengths of the five combined products are all located at 330 nm.

在稀HCl介质中,K3[Fe6]与阿莫西林、氨苄西林、氯唑西林钠、羧苄西林钠和青霉素钠等抗生素药物在加热条件下反应生成结合产物,会导致溶液的共振瑞利散射强度急剧增强,并产生新的RRS光谱,5种反应产物的最大散射峰均位于330 nm附近。

objective to analyze the drug resistance of staphylococcus aureusand provide suggestion for clinical rational use of antibiotics.methods secretion of those neonates suffered primary skin soft tissue infection and admitted during june,2005 to december,2007 was cultured and 113 strains of staphylococcus aureus were detected.we used k-b diffusion methods to determine their susceptibility to the common used antibiotics.results resistance rates of staphylococcus aureus to ampicillin/sulbactam,penicillin-g and cefazolin were 14.2%,40.7%and 6.2% respectively; there was no vancomycin-resistant strain.conclusion the resistance of staphylococcus aureus is not a serious problem in neonatal dermatic soft tissue infection.local treatment is the major approach in clinic,while general anti-infection consisting mainly of penicillin and first generation cephalosporin is chosen to avoid resistance mutation of staphylococcus aureus resulted from abuse of antibiotics.

多重聚合酶链反应快速鉴别葡萄球菌及。。。乳腺脓肿分离到葡萄球菌的鉴定和药敏。。。目的探讨金黄色葡萄球菌的耐药性,指导临床合理用药。方法对我院2005年6月至2007年12月新生儿原发性皮肤软组织感染患儿的分泌物进行培养,共检出金黄色葡萄球菌113株,并采用kb纸片扩散法对其进行常用抗生素的药敏试验。结果金黄色葡萄球菌对氨苄西林/舒巴坦、青霉素g及头孢唑啉的耐药率分别为14.2%、40.7%和6.2%,未发现耐万古霉素金黄色葡萄球菌。结论在新生儿皮肤软组织感染中金黄色葡萄球菌的耐药问题并不十分严重,临床处理应以局部为主,全身抗感染治疗宜以青霉素及i代头孢类抗生素为主,避免过度使用抗生素加速金葡菌的耐药突变。

OBJECTIVE To study the specific absorptivity and the formation ratio of ampicillinum natricum and p nitrophenol charge transfer compound.

目的 研究氨苄西林钠与对硝基苯酚形成电荷转移化合物的表观百分吸收系数、形成比及不经分离测定注射用氨氯青霉素钠中氨苄西林钠的含量的方法。

The synthetic route starts from penicillin G, peroxyacetic acid(8.5%) as Oxidizing Agent to get penicillin G sulfoxide; esterifided with p-nitrobenzyl bromine to synthesize penicillin G sulfoxide ester; we synthesize 3-exomethylenecepham sulfoxide ester with phthalimide potassium and 4A molecular sieve as acid scavenger to open the ring, SnCl_4 as catalyzation to close the ring. The yield is over 60%.

本研究采用的合成路线为:以青霉素G钾盐为原料,选用工业过氧化氢制备的过氧乙酸(22.3%)稀释至8.5%为氧化剂,氧化得青霉素亚砜;采用对硝基溴苄为酯化试剂,制备青霉素亚砜酯;以NCP(N-氯代邻苯二甲酰亚胺)为开环试剂,酞酰亚胺钾和4A型分子筛为酸清除剂,顺利开环;再经无水SnCl_4催化闭环得3-环外亚甲基头孢亚砜酯,最终产率在60%以上。

Take a Blue Sensitive Cyanine Dye and Ampicillinum Natricum an example. These two material both have good result and it it proved to be an effective tool for direct oscillographic analysis of organic.

以氨苄青霉素和感蓝染料3,3′-二(3-磺丙基)-4,5-苯并噻菁氢氧化物的三乙氨盐为例,二者在银盘电极上均有较好的示波响应,为示波分析直接进行有机分析提供了有效工具。

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