苄基溴

In the precence of the base catalyst KF/Al2O3, the one - pot reaction of 2 -hydroxybenzaldehyde or 2 - hydroxynaphthaldehyde with ethyl α- bromoacetate,α-bromoacetophenone , 1,4 - dichloromethylbenzene , 4,4'- dichloromethylbiphenyl and 1,5 -dichloromethylnaphthalene gave the benzofuran compounds in 38-89% yield.

本文报道用 KF/Al_2O_3作为碱催化剂，由水杨醛或2-羟基-1-萘醛分别和α-溴代乙酸酯、α-溴代苯乙酮、苄基氯、4，4'-二氯甲基联苯和1，5-二氯甲基萘等进行一锅化缩合反应，以38～89％的产率合成了14种芳并呋喃化合物。

A better understanding of the role of PPAR in insulin action system will be critical in developing more efficacious and safe agent s that act on PPAR and benefit patients with type 2 diabetes. The main content is followed: Synthesis and analysis of 1,3-dicarbonyl compounds. Make use of easily available cheap reagent such as 2-naphthol, 6-hydroxyquinoline, 1,2-dibromoethane, 4- hydroxybenzaldehyde, dimethyl malonate, 2-{4- [(2-napthoxy)ethoxyl] benzyl} malonates and 2-{4 [(1,2,3,4-tetrahydro-6 -quinolinoxy)ethoxyl] benzyl } malonates were synthesized through 6-8 steps in virtue of Williamson, Knoevenagel reaction, Pd/C catalyzed hydrogenation with mild conditions and high yield. The total yield of 40-50%.

本论文的主要内容和研究结果如下： 1，3-二羰基类化合物的合成及分析，采用2-萘酚、6-羟基喹啉、1 ，2二溴乙烷、对羟基苯甲醛、丙二酸二甲酯等常见易得试剂，利用Williamson反应、Knoevenagel反应、钯碳加氢等条件温和且收率高的方法，分别合成了2-{4- [(2-萘氧)乙氧基]苄基}丙二酸衍生物和2-{4 [(1，2，3，4-四氢-6-喹啉氧基)乙氧基]苄基}丙二酸衍生物两个系列8个化合物，经6-8步反应，总收率为40-50%，具有一定绿色化学特性。

This wor k deals with the effects ten of bromides and iodobenzene in catalytic hydrogenolysis debenzylation of 2,4,6,8,10,12-Hexabenzyl-2,4,6,8,10,12-hexaazaisowurtzitane.

研究了溴苯等10种溴化物及碘苯在六苄基六氮杂异伍兹烷催化氢解脱苄中的作用。

One synthetic strategy started fromγ-butyrolactone 38, from which a cyclohexadiene intermediate 30 was prepared in an overall yield of 44% in a 7-step procedure after y-butyrolactone underwent a-bromination, dehydrobromination, Diels-Alder reaction, aminolysis, benzylation, bromination and dehydrobromination, with the key step being the Diels-Alder reaction under harsh condition.

其中一个路线从γ-丁内酯38开始，连续经过α-溴化、脱溴化氢、Diels-Alder反应、胺解、苄基化、溴化和脱溴化氢共7步反应，制备了一个环己二烯衍生物30，总产率44％，关键步骤是高温高压下Diels-Alder反应。

Dibenzyl oxalate was synthesized from oxalic acid, potassium hydroxide and benzyl bromide under microwave irradiation using tetrabutylammonium bromide as phase-transfer catalyst and polyethylene glycol-200 as solvent.

在微波辐射条件下，以草酸、氢氧化钾和溴化苄为原料，四丁基溴化铵为相转移催化剂，聚乙二醇200为溶剂合成了草酸二苄酯，并通过熔点和红外光谱对产物的结构进行了表征。

Chapter 2 has analysized the conversly synthetic means of solanesol and designed novelly synthetic routes of solanesol and key intermediate Chapter 3 has summarized the preparation of trans-3-methyl-4-hydroxy (bromo-2-butenyl oxy methyl benzene In chapter 4 ,a novel technology of important intermediate(all trans-8-bromo geranyl acetate),which is suitable for industrial procedure , was found .meanwhile,an another new way has been invented ,of which the key intermediate (all trans-8-hydroxy geranyl acetate) has been produced.

第二部分分析了茄尼醇的逆合成方法，设计了一条适合于合成茄尼醇的合成路线及其重要中间体的合成路线。第三部分研究了重要中间体[Trans-3-甲基-4-羟基-2-丁烯基乙酰基(苄基，2，3-二氢吡喃基)醚]的合成新方法，找到了一条适合于工业化生产的制备反式-3-甲基-4-羟基-2-丁烯基苄基醚的新方法。第四部分研究了重要中间体[-3，7-二甲基-8-羟基-2，6-辛二烯-1-醇乙酸酯、-3，7-二甲基-8-溴-2，6-辛二烯-1-醇乙酸酯]的合成新方法，找到了一条适合于工业化生产的制备它们的新方法；同时研究了一条制备-3，7-二甲基-8-羟基-2，6-辛二烯-1-醇乙酸酯的另一新方法。

Benzyl phenylacetate was synthesized by benzyl chloride with the salt prepared by phenylacetic acid and Na2CO3 under microwave irradiation and in presence of phase transfer catalyst without any organic solvent and inorganic carrier.

采用微波辐射相转移催化技术，以四丁基溴化铵为相转移催化剂，先将苯乙酸与碳酸钠成盐，在无有机溶剂和无机载体的条件下与氯化苄直接酯化合成苯乙酸苄酯。

The related feature of tribromide quaternary ammonium salt as selective bromide reagent was investigated by the reaction of acetophanone, propanone, phenol with self-made benzyl triethyl tribromide quaternary ammonium salt.

首次通过自制的苄基三乙基三溴季铵盐与苯乙酮、丙酮、苯酚等的反应，研究了三溴季铵盐作为选择性溴化剂的相关性能。

Reaction of L-tyrosine with benzyl bromide in the presence of copper sulfate led to the protection of phenol group on the side chain of L-tyrosine to give H-Tyr-OH in 45% yield via a copper complex intermediate.

酪氨酸与溴化苄在硫酸铜存在下反应，选择性地在其侧链酚羟基上引入苄基保护基，通过反应条件的优化，反应产率达到45%。

L-Phenylalanine was then obtained by alkylation of N- glycine ethyl ester with benzyl bromide in the presence of an asymmetric phase-transfer catalyst-N-benzyl-cinchonine chloride, followed by hydrolysis of the resulting product.

以甘氨酸乙酯盐酸盐和二苯甲酮为起始原料合成了N-二苯亚甲氨基乙酸乙酯，后者在手性相转移催化剂-N-苄基氯化辛可宁诱导下与烷基化试剂溴化苄发生不对称相转移催化烷基化反应，水解得到L-苯丙氨酸。

Now, however, all children continue in "comprehensive" schools, and the eleven-plus determines which courses of study the child will follow.

然而现在，所有的孩子都要在综合学校继续学习，所以这次考试只是决定他们将要学习哪些课程。

Cultivatable land , and led to a general recognition that development must not be carried at the cost of agriculture .

城区的迅速扩大在很多情况下侵占了宝贵的可耕地，使人们普遍认识到发展不能以牺牲农业为代价。