芳基化

Reaction of NaOAr, SmCl_3 and aryloxo-functional N-heterocyclic carbene precursor [HO-4, 6-di-~tBu-C_6H_2-2-CH_2{CHMe}]Cl in 4:1:1 molar ratio in THF in one-pot hadnt afforded an anionic phenoxide complex of samarium (5) supported by a bridged bisphenoxo through the cleavage of aryloxo-functional N-heterocyclic carbenes.

4将NaOAr、SmCl_3和[HO-4，6-di-~tBu-C_6H_2-2-CH_2{CHMe}]Cl以4∶1∶1摩尔比，采用一锅煮的方法，希望得到芳氧基功能化的氮杂环卡宾稀土芳氧配合物没有取得成功，而是得到了断裂的产物O-4，6-di-~tBu-C_6H_2-2-[CH{NNMe}[(O-4，6-di-~tBu-C_6H_2)_2CH_2][O-2，4-di-~tBu-C_6H_3]Sm(5)。

Unsaturated alkynyl alcohols, such as dehydronerolidol, dehydrogeranyllinalool, and dehydroisophytol, were prepared by ethynylation of turpentine derivatives, namely terpenylacetones, e. g. geranylacetone, farnesylacetone, and phyton under normal pressure in presence of alkali metal hydroxide and organic solvents.

松节油衍生物格萜烯基丙酮，如香叶基丙酮、金合欢基丙酮和植物酮在常压条件，碱金属氢氧化物和有机溶剂存在下可发生乙炔化反应，形成对应的α，β-不饱和炔醇化合物脱氢橙花叔醇、脱氢香叶基芳樟醇和脱氢异植物醇。

O-(1-Arylseleno-3-azido)isopropyl-O-2-(N3-tegafur)alkyl thiophosphate (3a～3f) were obtained via nu-cleophilic ring-opening of sodium azide to 2a～2f in dry DMF at room temperature, and their antitumor activities were tested.

以无水N，N-二甲基甲酰胺作溶剂，室温下，叠氮化钠中对2a～2f进行亲核开环，得到O-(1-芳硒基-3-叠氮基)异丙基-O-2-(N3-替加氟)乙基硫代磷酯。

Poly with sulfonic acid groups were readily synthesized with biphenol and 1,3-bis(4-fluorobenzoyl)benzene in the presence of excess potassium carbonate followed by sulfonation with chlorosulfonic acid.

以二氯二苯甲烷和2，6-二甲基苯酚为原料合成了含有阻碍基团的双酚单体，用此双酚单体和1，3-二(4-氟苯甲酰基苯)在无水碳酸钾存在的条件下反应制得聚芳醚酮，然后用氯磺酸磺化，控制反应条件，使磺酸基团恰好进入苯环对位，制得新型结构的磺化聚芳醚酮。

A series of sulfonated poly(arylene thioether/ether phosphine oxide)s was prepared by direct polycondensation of sBFPPO and BFPPO with the diphenol-type or dimercapto-type monomers such as hydroquinone, bisphenol-A, 4,4'-biphenol, 4,4'-diphenol (6F), 1,5-dihydroxynaphthalene, 4,4'-dihydroxybiphenyl, and 4,4'-thiobisbenzenethiol, respectively.

将BFPPO与sBFPPO分别与多种二羟基或二巯基单体，如对苯二酚、双酚A、4，4'-二苯酚、双酚F、1，5'-二羟基萘、4， 4'-二羟基二苯硫醚和4，4'-二巯基二苯硫醚，直接共聚制备了一系列磺化聚芳醚三苯基氧膦，侧重考察了二羟基和二巯基单体结构单元对产物的耐氧化性能的影响。

To explore new synthetic methods, we set out a careful investigation of the reaction of benzimidazolium salt with many nucleophilic agents, including the active aromatic compounds and heteratom nucleophilic agents, and found that the quaternary C=N is not so active; when benzimidazolium salt is reacted with big nitrogen nucleophilic agent? phthalimide, it does not give the expected addition product, instead, produces N-alkyl phthalimide through alkyl-transfermation from benzimidazolium salt to phthalimide.

为了开发新的合成方法，研究了苯并咪唑盐与各种亲核试剂（活泼芳环与杂原子亲核试剂）的反应，发现苯并咪唑盐不与活泼芳环及杂原子亲核试剂发生2位加成反应；在与体积较大的位阻型N亲核试剂邻苯二甲酚亚胺反应时，未得到亲核试剂与极化的C＝N的加成产物，而是得到N烷基化的邻苯二甲酰亚胺，进一步研究表明，苯并咪唑盐将1（3）位N上的烷基转移给了邻苯二甲酰亚胺，并讨论了其反应机理和取代基，溶剂效应。

A sulfonated poly aryl ether with sulfonic group on naphthalene ring of side chain and preparation thereof, which is capable to solve technical problems of complexity in synthesis, hardness in controlling sulphonation position and degree, high possibility of side reaction in sulphonation, complexity in sulphonation and hardness to realize indutrialzation.

一种磺酸基在侧链萘环上的磺化聚芳醚及其制备方法，解决现有技术中合成方法复杂，磺化位置和磺化度难以控制，磺化过程中容易发生多种副反应，磺化工艺复杂难以实现工业化等技术问题。

In order to obtain versatile ulitity of host molecules, three new chiral calix [4] crown ethers containing aza, thio atoms bearing two chiral sites provided by -cysteine ester were synthesized by the condensation of calix [4] arene diacid dichloride with oligoethylene glycol bridged bis-amino acid methyl ester. All new compounds were characterized by NMR, MS and elemental analysis.

以-半胱氨酸为手性源，利用多甘醇二氯醚在碱性条件下对半胱氨酸巯基进行烷基化反应，成功地合成了多甘醇醚链桥联的半胱氨酸衍生物，醚化反应后，在高度稀释条件下与对叔丁基杯[4]芳烃二乙酰氯进行双功能基缩合反应成功地合成了新型的手性杯[4]含氮、硫杂冠醚，并利用〓H NMR、MS等谱图手段对其结构进行了表征。

The application results from fluorination showed microwave heating could accelerate chemical reactions markedly. The reaction time could be shortened 50% at least than that of conventional heating. The relationship between fluorinating agents\' structure and their activity was studied systematically. In addition, an anhydrous KF with higher activity was prepared by using expansion effect of microwave heating. As we known, solvents were very important to reaction. The comprehensive study showed some less polar aromatic solvents could be used as dipolar solvents. In addition, they had better effect than dipolar solvents in some occasions, such as fluorination of chlorobenzaldehydes and chlorinated diphenyl ketones etc. The primary applications of ionic liquids were also studied which indicated reactions with ionic liquids as solvents were more efficient and simple.

研究表明，微波是一种节能高效的加热方式，在微波作用下的卤素交换氟化反应具有反应速度快、转化率高、选择性好的优点，其反应时间可较常规加热缩短50%以上；同时也系统地研究了氟化剂种类及制备方式对其反应活性的影响，并利用微波加热的膨化作用制备出了一种活性较高的KF，其活性与喷雾干燥KF相差不大；溶剂对反应具有重要的作用，在此系统地研究了强极性非质子溶剂和中等极性非质子溶剂的应用情况，发现一些中等极性的非质子溶剂如硝基芳烃和氯代芳烃类溶剂在氯代苯甲醛类化合物的氟化反应中具有比强极性非质子溶剂更好的使用效果。

The main contents are as follow: 1. Calixarenes and their derivatives were synthesized. Their structures were characterized by infared spectroscopy, thermal analysis and mass spectrometry. Their purities were detected by HPLC with more than 90%.

合成杯芳烃母体及其衍生物，采用红外光谱、热分析和质谱法对其进行表征，用高效液相色谱的面积归一化法测定其纯度，得到纯度在90％以上的对叔丁基杯[4、6、8]芳烃和杯[4、6、8]芳烃。

Breath, muscle contraction of the buttocks; arch body, as far as possible to hold his head, right leg straight towards the ceiling (peg-leg knee in order to avoid muscle tension).

呼气，收缩臀部肌肉；拱起身体，尽量抬起头来，右腿伸直朝向天花板（膝微屈，以避免肌肉紧张）。

The cost of moving grain food products was unchanged from May, but year over year are up 8%.

粮食产品的运输费用与5月份相比没有变化，但却比去年同期高8％。