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Calcium pectinate gel beads and calcium alginate gel beads are suitable preparation of ketoprofen exhibiting mucoadhesive characteristics, but their release behaviors are different.

酮洛芬果胶钙凝胶小球和酮洛芬海藻酸钙凝胶小球通过与生物黏膜的紧密结合缓慢释药,而二者的释放行为有所不同。

Ketoprofen released from calcium pectinate beads mainly through diffusion behaviors, whereas the release of ketoprofen from calcium alginate gel beads was ruled by corrosion of carrier material.

酮洛芬果胶钙凝胶小球和酮洛芬海藻酸钙凝胶小球通过与生物黏膜的紧密结合缓慢释药,而二者的释放行为有所不同。

Results Ketoprofen calcium pectinate gel beads and calcium alginate gel beads showed excellent drug release pattern and mucoadhesiveness. Ketoprofen released from calcium pectinate beads mainly through diffusion behaviors, whereas the release of ketoprofen from calcium alginate gel beads was ruled by corrosion of carrier material.

结果 酮洛芬果胶钙凝胶小球和酮洛芬海藻酸钙凝胶小球均具有良好的生物黏附性能,果胶钙凝胶小球主要通过溶胀作用缓慢释药,而海藻酸钙凝胶小球的释药与凝胶小球慢慢吸水后骨架溶蚀有关。

It was also noted that lipases preferentially esterify the S-isomer of ibuprofen, thus the scheme for resolution of ibuprofen in organic solvent can be expressed as follows

实验中发现脂肪酶优先酯化布洛芬S-对映体,因此在有机相中用脂肪酶催化酯化拆分布洛芬的方案可表示如下

Methods: Data from the Fracture Prevention Trial and the Multiple Outcomes of Raloxifene Evaluation trial were analyzed to determine the incidences of new adjacent and new nonadjacent vertebral fractures in the placebo groups and the effect of treatment with raloxifene and teriparatide on the incidence of new adjacent vertebral fractures as compared with that of new nonadjacent vertebral fractures.

研究数据来自于骨折防预试验中心,比较雷洛昔芬与安慰剂组对椎体骨折后再发生邻近椎体骨折及非邻近椎体骨折的发生率以及应用特立帕肽、雷洛昔芬对椎体骨折后再发生邻近椎体骨折及非邻近椎体骨折的风险情况。

Objective To synthesis flurbiprofen triethanolamine salt,and study the in vitro transdermal permeation properties of flurbiprofen and Flu-TEA.

目的合成氟比洛芬三乙醇胺复合物,考察氟比洛芬及Flu-TEA的体外经皮透过性。

Rockefeller's son Steven Clark Rockefeller III, his nephew Collin Clark Eckles, Douglas C. Spooner, counselor of Rose Rock Partners, LLC (Rockefeller Group Wholly Owned Holding Company), Timothy R. Gaarn, Mr. Rockefeller's business partner, Richard M. Hammer, counselor of Rose Rock Partners, LLC (Rockefeller Group Wholly Owned Holding Company), Mr. Ken W. Chin and partners of Rose Rock Partners, LLC (Rockefeller Group Wholly Owned Holding Company), and partner assistant, Mr. Gregory John Burie.

同行的还有洛克菲勒先生的儿子史蒂芬·克拉克·洛克菲勒先生、洛克菲勒先生的侄子科林·艾克雷先生、玫瑰岩公司顾问道格拉斯·斯布纳先生、洛克菲勒先生合作伙伴迪莫斯·刚先生、玫瑰岩公司顾问理查·海默先生、玫瑰岩公司合伙人陈健先生及玫瑰岩公司合伙人助理,格瑞·博瑞先生。

The significant linear correlation existed between the dissolution in virtro and the absorption in vivo (P<0.01). CONCLUSION: The size distribution of FP-GMS was focalizing,and FP-GMS had obviously sustained effect in vitro and in vivo.

本法制备的氟比洛芬明胶微球粒径分布集中,粒径大小符合设计要求,体内外释药结果表明氟比洛芬明胶微球具有明显的缓释作用。

The conditions was as follows: Maxima 820 workstation,Hypersil column ODSC_(18)(4.6mm×200mm 5μm),UV detective wavelength 247nm,Flow rate 1.0ml/min,sensitivity 0.01 AUFS Mobile phase is composed of acetonitrile,H_2O,methanol(45:55:1).By which the inerference of impurity may be avoided and there is a good linear relationship between concentration and peak area.

本文建立了体内外氟比洛芬样品的HPLC测定方法:色谱柱:4.6mm×200mm Hypersil ODSC_(18)(4.6mm×200mm 5μm,)紫外检测波长247nm;流动相为乙腈:水:甲醇=45:55:1,流速:1.0ml/min;柱温:室温;灵敏度:0.01AUFS,进样量:20μL,该法可将氟比洛芬与杂质分离,浓度与峰面积之间呈良好的线性关系,满足分析要求。

The results showed that:(1) The drug micropellet with reasonable drug entrapment ratio and release velocity would be obtained if the amountof crosslinking agent and drugs was controlled successfully;(2) The Ibuprofen micropellet had a suitable release rate in artificial intestinal juice but it was a very low release rate in artificial succus gastrius because it had a low solubility in acid medium.

以环氧氯丙烷为交联剂,羟丙基壳聚糖为载体,将布洛芬做成缓释控释药物微丸,讨论了包埋条件对微丸性能的影响以及药物在人工胃液和人工肠液中的释放行为。结果表明:(1)合理控制交联剂用量和药物投入量,能够得到药物包封率和释放性能良好的药物微丸;(2)布洛芬药物微丸在人

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