芬

The present invention relates to medicine technology and is especially one kind of new preparation form. The transdermal plaster is noe kind of antiphlogistic containing Flubiprofen, Ketoprofen, Ibuprofen, Rosorolfen, Naproxan and other aryl propionic non-steroid.

本发明涉及医药技术领域，特别是氟比洛芬、酮洛芬、布洛芬、罗索洛芬和萘普生等芳基丙酸类非甾体抗炎药的透皮给药制剂中一种新剂型――透皮贴剂。

The influences of the shock thickness and Alfven waves on the particle acceleration by diffusive shock waves are numerically studied through solving one-dimensional diffusive equation including the second-order Fermi effect. It is shown that the spectral index of the energetic particles strongly depends on the shock thickness. For example, the spectral index increases from 2.1 to 3.7 in the low energy range of 3-10 MeV and from 2.5 to 5.0 in the high energy range of 20-60 MeV as the thickness increases. The spectral index decreases from 4.3 to 3.1 as the particle injection energy increases. The spectral index decreases from 4.0 to 1.8 at the quasi-steady stage with the enhancement of the compression ratio from 2 to 4. The results indicate that under the influence of Alfven waves, the energetic particle spectrum at lower energy becomes flat and the spectral index decreases from 2.5 to 0.6 in the low energy range of 3-10 MeV and from 11.6 to 5.0 in the high energy range of 20-60 MeV. At the same time, the rollover energy reaches 19.6 MeV. The spectral index decreases from 5.8 to 2.9 as the energy density of Alfven waves increase. All these results are basically consistent with the theoretical models, as well as the observations of typical energetic particle events.

通过数值求解包含二阶费米加速的一维扩散方程，探讨在准平行激波条件下激波厚度和级联阿尔芬波对粒子加速的影响，研究粒子分布函数的演化与激波厚度和阿尔芬波强度的内禀关系，计算结果表明：(1)考虑激波厚度时，谱指数明显依赖于激波厚度，随着厚度从0.32增大到2.56，低能端(3-10MeV)谱指数逐渐从2.1增加到3.7，高能端(20-60MeV)谱指数从2.4增大到5.0，能谱逐渐变软；当初始注入粒子动量增大1.3倍，质子能谱指数从4.3减小到3.1，且与零厚度激波加速的谱指数差值缩小；厚度不变时，随着压缩比从2增加到4，准稳态分布时低能端(3-10MeV)粒子能谱指数逐渐从4.0减小到1.8谱变硬；(2)在级联阿尔芬波的影响下，随着时间的增大，粒子在低能处(3-10MeV)的谱指数从2.5减小到0.6高能端(20-60MeV)谱指数从11.6减小到5.0，能谱变硬，拐点能量值从7.5MeV增大到为19.6MeV；随着波的能量密度增大，谱指数从5.8减小到2.9，这表明阿尔芬波强度越大，加速效率越高，通过与激波厚度解析结果和高能粒子事件的观测能谱比较发现两者是一致的，说明数值模拟结果是可靠的。

In summary, the drive current by Alfvén waves can be enhanced by plasma rotation The negative magnetic shear is favorable for the efficiency of the current drive by Alfvén waves Moreover, in the reversed shear configuration the current drive due to Alfvén waves in an rotation plasma can obviously change the plasma current profile The Alfvén wave current drive may be useful in controlling the current profile in order to suppress magnetohydrodynamic instabilities.

另外，我们还发现负剪切区域愈大，同时安全因子极小值q〓愈小，对阿尔芬波电流驱动愈好。总之，等离子体极向旋转能够增强阿尔芬波电流驱动，负磁剪切对阿尔芬波电流驱动是有利的。另外，反磁剪切位形下旋转等离子体的阿尔芬波电流驱动可以明显改善等离子体电流剖面。

On the rhombohedron face {1011}, Dauphine twinning showed different shapes of etching pits between individuals, because rhombohedron positive form {1011} and negative form {0111} appeared on both sides of twin partition line, while Brazil twinning showed symmetry plane between the irregular triangle etching pits of individuals. On the trigonal prism section 11(average20, Dauphine twinning showed different shapes of etching pits between individuals, because trigonal prism positive form {1120} and negative form {2110} appeared on both sides of twin partition line, while Brazil twinning should show symmetry plane between the ellipse or quadrilateral etching pits of individuals, which was not observed.

菱面体{1010}面上存在道芬双晶处，道芬双晶双晶缝合线两端分别是菱面体正形、菱面体负形出露处，导致蚀坑形状不同；菱面体{1011}面上存在巴西双晶处，不规则三角形蚀坑形态的方位关系为对称面关系；三方柱切面{1120}面上存在道芬双晶处，道芬双晶双晶缝合线两端分别是三方柱正形、三方柱负形出露处，导致蚀坑形状不同；三方柱切面{1120}面上存在巴西双晶处，椭圆形或四边形蚀坑方位应为对称面关系，但实验中未见到。

It is also considered to study the Finsler geometry which deal with the Chern''s connection、flag curvature、Ricci scalar of Finsler manifolds、Finsler submanifold geometry, and harmonic maps between Finsler manifolds.

研究芬斯勒几何的某些问题，包括芬斯勒流形的陈省身联络、旗曲率、Ricci数量、芬斯勒子流形几何以及芬斯勒流形间的调和映射等。

Methods Seven probe drugs were incubated with or without methyl protodioscin respectively in human microsomes. The specific substrates used in this study were caffeine (CYP1A2), dextromethorphan (CYP2D6), tolbutamide (CYP2C9),-mephenytoin (CYP2C19), chlorzoxazone (CYP2E1), coumarin (CYP2A6) and midazolam (CYP3A4). The concentrations of the substrate metabolites (paraxanthine, dextrorphan, 4-hydroxytolbutamide, 4-hydroxymephenytoin, 6-hydroxychlor-zoxazone, 7-hydroxycoumarin and 1-hydroxymidazolam) were determined by HPLC and LC-MS/MS. Results MPD 1-10 μmolL^(-1 had no significant inhibition on the activities of the seven cytochrome P450 enzymes.

将MPD和CYP450酶7种亚型的特异性探针底物咖啡因(CYP1A2)、右美沙芬(CYP2D6)、甲苯磺丁脲(CYP2C9)、s-美芬妥因(CYP2C19)、氯唑沙宗(CYP2E1)、香豆素(CYP2A6)及咪达唑仑(CYP3A4)与人肝微粒体进行孵化反应，采用HPLC和LC-MS/MS法测定对应的7种代谢产物（1，7-二甲基黄嘌呤、去甲右美沙芬、4-羟基甲苯磺丁脲、4-羟基美芬妥因、6-羟基氯唑沙宗、7-羟基香豆素和1-羟基咪达唑仑）的浓度，通过与对照组比较，确定MPD对以上7种酶活性的影响。

They were randomized into 4 groups which wererespectively given intragastric administration of raloxifene of 1mg/kg/d, raloxifeneof 1mg/kg/d with estradiol valerate of 0.02mg/kg/d, raloxifene of 1mg/kg/d withestradiol valerate of 0.1mg/kg/d, raloxifene of 1mg/kg/d with estradiol valerate of0.4mg/kg/d.

随机分为4组，术后一周开始分别给予雷洛昔芬1mg／kg／d、雷洛昔芬1mg／kg／d+补佳乐0.02mg／kg／d、雷洛昔芬1mg／kg／d+补佳乐0.1mg／kg／d和雷洛昔芬1mg／kg／d+补佳乐0.4mg／kg／d，药物干预3个月。

In the artificial rearing larval honeybee method, 1-day-old larvae were reared in laboratory and 0.1 - 100 ppm pyriproxyfen was added in larval food. A dose respondent effect was found in the larval development of the treated larvae. Results showed that 0.1 ppm pyriproxyfen reduced the eclosion rate of the reared larvae conspicuously, and 1 ppm pyriproxyfen reduced that 84.6% of eclosion honeybee appeared the condition of deformed wings. The 10 ppm pyriproxyfen treatment caused 53.8% melanic death in the pupal stage, and no honeybees succeed in eclosion.

在室内饲养幼虫方面，分别添加0.1-100 ppm百利普芬於幼虫食物中，结果显示0.1 ppm百利普芬即会显著降低饲养幼虫的羽化率，而且添加1 ppm百利普芬会有84.6%羽化蜜蜂出现残翅现象；添加10 ppm百利普芬则会造成53.8%蜜蜂在蛹期黑化而死亡，而且无蜜蜂羽化成功；100 ppm百利普芬则有50%蜜蜂在幼虫期死亡，50%蜜蜂在蛹期死亡，亦无蜜蜂成功羽化。

From three trials comparing Terbinafine with Itraconazole, a statistically significant advantage in favour of Terbinafine was observed for negative culture and microscopy at the end of the trials. From two trials comparing Terbinafine with Griseofulvin, a significantly higher rate of negative microscopy and culture was observed with Terbinafine.

结果 入选的特比奈芬与安慰剂比较的研究有3项，特比奈芬与伊曲康唑比较的研究有3项，在临床试验结束阶段的真菌镜检和真菌培养转阴率方面，特比奈芬明显高于对照组和伊曲康唑组，并且具有统计学意义，而且认为特比奈芬在耐受性方面优于伊曲康唑；特比奈芬与灰黄霉素比较的临床试验有2项，特比奈芬的真菌治愈率明显高于灰黄霉素。

In 1885, the two提斯特temperature巴珀John and Richard Adolf克霍芬the mechanics夫杰尼克in Chemnitz opened a bicycle repair line.

1885年，两位名叫约翰·巴珀提斯特·温克霍芬和理查德·阿道夫·杰尼克的机械工在开姆尼斯（Chemnitz开了一家自行车修理行。

Plunder melds and run with this jewel!

掠夺melds和运行与此宝石！

My dream is to be a crazy growing tree and extend at the edge between the city and the forest.

此刻，也许正是在通往天国的路上，我体验着这白色的晕旋。