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Objective To observe the pathological changes and investigate the hepatocyte apoptosis relating with CYP2E1 in alcoholic liver diseaseof rat. Method the Model of Alcoholic liver Disease: Rats were randomly divided into model group(n=37)and control group(n=33). The dose of 40%ethanol was administerd at 8g/kg body weight by garage twice daily for 8 weeks in model group, and control group was received isovolume saline by gavage. End of 8th week, the activities of serum ALT and AST were detect by autobiochemistry instrument. The pathological changes of liver was observed under light microscope after HE staining, hepatocyte apoptosis was detected by the TUNEL method.

目的: 研究酒精性肝病细胞凋亡程度与细胞色素P4502E1表达的关系方法:用酒精灌胃法制备大鼠酒精性肝病模型,将70只wistar大鼠随机分为正常对照组(33只)和酒精灌胃组(37只),连续灌胃8周后病理切片观察细胞凋亡程度,干化学法测定ALT、AST的含量变化,用PCR法测定细胞色素P450 2E1的表达变化。

Reasonable evidence suggests that the anthocyanidin/proanthocyanidin moieties are potent antiadhesion compounds.

合理的证据表明花色素/原花色素成分是潜在的抗粘附的复合物。

AbstractWe present the early diagnosis method of agerelated macular degeneration , and characterize various pathological changes arising in the development of AMD, such as drusen, chorioretinal mapshrinking, retinal pigment epithelial atrophy, choroidal neovascularization, retinal pigment epithelium and neural epithelial detachment, and so on. We analyze its images by using optical coherence tomography.

本文给出了一种老年性黄斑变性(agerelated macular degeneration, ARMD )的早期诊断方法,在 ARMD 的发展过程中出现的各种病理改变如玻璃膜疣、脉络膜视网膜地图状萎缩、视网膜色素上皮萎缩、脉络膜新生血管、视网膜色素上皮/神经上皮脱离等,用光学相干断层成像技术(optical coherence tomography,OCT)对其进行图像分析。

AbstractWe present the early diagnosis method of agerelated macular degeneration , and characterize various pathological changes arising in the development of AMD, such as drusen, chorioretinal mapshrinking, retinal pigment epithelial atrophy, choroidal neovascularization, retinal pigment epithelium and neural epithelial detachment, and so on.

本文给出了一种老年性黄斑变性(agerelated macular degeneration,ARMD)的早期诊断方法,在ARMD 的发展过程中出现的各种病理改变如玻璃膜疣、脉络膜视网膜地图状萎缩、视网膜色素上皮萎缩、脉络膜新生血管、视网膜色素上皮/神经上皮脱离等,用光学相干断层成像技术(optical coherence tomography,OCT)对其进行图像分析。

The cyanin of Acer ginnala had low light and heat stability.It could hold the cyanin stability under low temperature and dark condition.

茶条槭的花色素苷表现出光、热稳定性差的明显特征,低温和黑暗条件能较好地保持花色素苷的稳定性。

The bacterial, mammalian and plant cytochrome P450s involved in metabolism of herbicides are reviewed in this paper. The action modes of cytochrome P450s on herbicides including dealkylation, ring-methyl hydroxylation and aromatic ring hydroxylation etc are summarized.

本文综述了代谢除草剂的细菌、哺乳动物和植物细胞色素P450酶系,概述了细胞色素P450酶系参与除草剂代谢的作用方式:脱烷基化作用、环甲基化羟基化作用和芳环的羟基化作用等。

The patients showed a mixed of hyperpigmented and hypopigmented macules symmetrically distributed on the extremities, which are typical DSH.

中国人DSH的典型表现为患者的肢端有色素沉着和色素减退的网状斑,对称分布,小部分患者面部有雀斑样损害,严重者可累及躯干等部位。

Histopathology of the hyperpigmented lesion revealed increase of melanin in the basal layer, pigment incontinence and amorphous eosinophilic masses stained positive as with Congo red in the papillary dermis.

色素沉著的病灶其组织病理显示在基底层有黑色素的增加,乳突状真皮出现色素失调和均质的嗜伊红性块状物质沉积,且以刚果红染色呈阳性反应。

Results: When the concentrations of artemisinin were 1×10^(-4), 1×10^(-5) and 1×10^(-6)mol/L, the growth of cells was inhibited remarkably in a dose-dependent manner. Fluorescence staining showed obvious apoptosis, such as karyopyknosis and agglutination. RT-PCR assay shows the expression of Caspase-3. Artemisinin could lead to the decrease of mitochondrial cytochrome c concentration, which in turn lead to the increase of cytoplasmic cytochrome c concentration.

结果:青蒿素的浓度为1×10^(-4),1×10^(-5),1×10^(-6)mol/L时,细胞生长受到显著抑制,并呈剂量依赖性;Hoechst33342/PI双荧光染色可观察到明显的核浓缩、凝集等细胞凋亡表现;RT-PCR检测到Caspase-3的表达;Western-blot检测1×10^(-5)mol/L药物处理细胞后线粒体细胞色素C表达水平下调,细胞浆出现明显细胞色素C蛋白条带。

Use 1064nm laser treatment of black and blue pigments, in the treatment of sharp color laminae very deep tissue, since melanin on laser energy of strong absorption, can produce strong pigment burst with strong sound.

用1064nm激光治疗黑色及蓝色色素时,在治疗纹色纹层很深的组织时,由于黑色素对激光能量的强烈吸收,可能产生较强的色素爆裂并伴随强声响。

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