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You will never succumb to challenges of hardships.

你从来不会屈服于困难的挑战。

Their efforts in thwarting pirate attacks have been credited with significantly reducing the number of successful pirate boardings there for the first three months of this year.

他们的努力挫败了许多海盗袭击,大幅度减少了今年头3个月海盗成功登船劫持的数量。

This paper reviews the kinetic mechanism of acetylcholinesterase, illustrates the principle and application of the kinetic parameters such as Michealis-Menten affinity constant Km, maximum reaction velocity Vmax, turnover number Kcat, bimolecular rate constant Ki, affinity constant of the inhibitor for the a ctive site Ka, phosphorylation or carbamylation rate constant K2, and discusses the potential practical application benefiting from the study of the kinetic analysis.

综合评述了AChE的动力学机制的发展状况,着重介绍了米氏常数Km、最大反应速率Vmax、转换率Kcat、双分子速率常数Ki、抑制剂化合物对AChE活性部位的亲和力常数Ka、磷酸化或氨基甲酸化速率常数K2,这些动力学参数的原理及其应用状况,探寻了动力学机制将带来的实际应用。