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A heavy yellow poisonous oily explosive liquid obtained by nitrating glycerol; used in making explosives and medically as a vasodilator.

一种重的、黄色有毒油状爆炸性液体,由甘油硝化制成,用于制炸药,医学上用作血管舒张药。

The restrictive filling pattern is distinguished from overfilling of a normal ventricle by a reduced and delayed E' and a shortened E deceleration time that reflect slow relaxation and increased LV stiffness.

限制性充盈模式是区别二尖瓣环流速峰值减少和延缓导致的正常心室过度充盈与更短的二尖瓣血流E峰减速时间导致的正常心室过度充盈,其反映了舒张功能变得迟缓和左室室腔僵直程度的增加。

Methods The effects of three vasodilators on the potassium chloride, norepinephrine concentration-response curves and precontracted rabbit aorta were investigated.

以离体兔主动脉条观察该三种血管舒张药对氯化钾、去甲肾上腺素量效曲线及预收缩血管的影响。

Effects of H_2O_2 on the tension of isolated aortic rings of rat As above methods,Our results indicated that (1) aortic rings with endothelium precontracted by NE to 10000μmol/L H_2O_2 induced a relaxation; aortic rings with endothelium to 100μmol/L H_2O_2 induced a significant contraction;H_2O_2 induced the same effects in aortic rings without endothelium, there is significant difference in presence and absence of endothelium.

双氧水对大鼠离体血管环张力的影响方法同2,结果:①NE预收缩后,加入10000μmol/L H_2O_2,内皮完整血管环表现为舒张作用;加入100μmol/L H_2O_2后血管环表现为收缩作用;H_2O_2对去内皮的血管环同样具有上述作用,与内皮完整组相比差异显著;②10000μmol/L H_2O_2可使得内皮完整及去内皮血管环中NO含量升高;100μmol/L H_2O_2可使得NO含量降低。

Our results indicated that (1) aortic rings with and without endothelium precontracted by NE to decreased pH induced a relaxation; aortic rings with and without endothelium to increased pH induced a contraction; there is no significant difference in presence and absence of endothelium .(2)NO levels had no significant change in isolated aortic rings presence and absence of endothelium to decreased pH and increased pH ;(3)sulfite levels in isolated aortic rings with endothelium reduced to decreased pH and increased pH. sulfite levels in aortic rings without endothelium had no remarkable change.

结果:①NE预收缩后,pH值降低对内皮完整和去除内皮胸主动脉血管环呈舒张作用;pH值升高对内皮完整和去除内皮胸主动脉血管环呈收缩作用;内皮完整组与去内皮组相比无显著性差异;②pH降低和升高对内皮完整和去除内皮血管环中NO含量无显著性影响;③pH降低和升高均可使内皮完整血管组织中亚硫酸盐含量减少,对去内皮血管中亚硫酸盐无显著性影响。

Isolated rat pulmonary artery was perfused and the tension of the vessel was measured, the effect of isopropyl 3-(3,4-dihydroxyphenyl)-2-hydroxypropanoate on the pulmonary artery precontracted by noradrenaline and concentration-response curves of 5-hydroxytryptamine(5-HT), endothelin-1(ET-1), U46619 and KCl was also observed.

制备大鼠肺动脉条,采用离体血管灌流方法,观察丹参素异丙酯对去甲肾上腺素预收缩动脉的舒张作用以及对多种血管收缩药量效曲线的影响。

Our results indicated that (1)SO_2 derivatives could dose-dependently relax the isolated aorta rings with or without endothelium precontracted by NE, no difference was found for the rings with and without endothelium;(2)Levels of cAMP and 6-Keto(PGI_2) in isolated aortic rings were increased by SO_2 derivatives in a dose-dependent way, which were independent of endothelium;(3)SO_2 derivatives decreased cGMP levels in the rings, but not significantly; The decrease of cGMP levels was also independent of endothelium;(4)No changes of TXB_2 in rings with or without endothelium were observed;(5)Whether presence or absence of endothelium, cAMP/cGMP and 6-Keto/TXB_2 ratios were increased significantly.

结果:①SO_2衍生物对去甲肾上腺素预收缩的内皮完整和去除内皮的大鼠胸主动脉血管环均呈浓度依赖性舒张作用,且其张力变化在内皮完整与去内皮的血管环之间无显著性差异;②SO_2衍生物可引起血管组织中cAMP、6-Keto(即PGI_2)含量剂量依赖性增加,其增加程度与内皮无关;③SO_2衍生物对血管环cGMP含量呈降低趋势但在统计学上无显著意义,且对去除内皮血管无显著影响;④SO_2衍生物对去内皮或内皮完整血管环的TXB_2含量均无明显影响;⑤无论是否去除内皮,SO_2衍生物均可引起cAMP/cGMP和6-Keto/TXB_2比值显著升高。

Result: Isopropyl 3-(3,4-dihydroxyphenyl)-2- hydroxypropanoate exerted relaxation effect on the endothelium-intact artery precontracted by NE in a concentration-dependent manner, which was inhibited with denuded endothelium. The right-shift of the concentration-response curves of 5-HT, ET-1, U46619 and KCl.

结果:丹参素异丙酯可浓度依赖性舒张NE预收缩的完整内皮血管,去内皮后该作用明显降低;对5-羟色胺(5-HT)、内皮素(ET-1),U46619和KCl量效曲线均表现浓度依赖性抑制。

After pericardial effusion,the diastolic pressure of right ventricle and pulmonary vein pres-sure pulsated with intrathoracic pressure;the pressure of carotid vein and femoral vein were still stable.

颈内静脉及股静脉压较稳定,波动幅度较小,分别为0.06kPa和-0.06kPa;心包填塞后,胸内压呼吸性波动加大,左右心室舒张压、肺静脉压的波动幅度随之加大,但颈静脉压及股静脉压仍较稳定。

RESULTS Before pericar-dial effusion,the diastolic pressures of ventricles and pul-monary pressure pulsated with intrathoracic pressure,and pressures of carotid vein and femoral vein were stable.

通过制作狗的心包积液模型,描记积液前后胸内压、左右室舒张压、外周大静脉压及肺静脉压的呼吸性波动曲线,计算其波动值并进行统计学处理。

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This one mode pays close attention to network credence foundation of the businessman very much.

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