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FMD of the brachial artery was examined by high-resolution ultrasonography technique and the inter-ventricular septum thickness, left ventricular posterior wall thicknessand left ventricular diastolic diameter were measured by echo-cardiography technique. The left ventricular mass and LVMI were calculated according to Devereux formulary. According to Framingham heart study, The hypertensive individuals were separated into two groups, left ventricular hypertrophy group and without left ventricular hypertrophy group.

利用高分辨超声技术测定肱动脉血流介导的舒张功能;超声心动图评价受试者的心脏结构功能,测量室间隔厚度(inter-ventricular septum thickness, IVST)、左室后壁厚度(left ventricular posterior wall thickness, LVPWT)及左室舒张末内径(left ventricular diastolic diameter, LVDD),根据Devereux公式计算(left ventricular mass, LVM)按体表面积得出LVMI,并据Framingham心脏研究的标准将高血压组分为左室肥厚组(24例)与无左室肥厚组(31例)。

We hypothesized that nitrite would have a greater dilator effect in capacitance than in resistance vessels because of lower oxygen tension and that resistance-vessel dilation should become more pronounced during hypoxemia.

我们猜测,因为较低的氧分压,容量血管和阻力血管相比,对亚硝酸盐有更强的舒张作用。而在缺氧状态下,阻力血管的舒张更加明显。

The purpose of this study was to investigate the vasorelaxing effect of vasonatrin peptide on human intramammary artery.The vasorelaxing effect of VNP on HIMA was measured by means of perfusion in vitro. The effects of HS-142-1, TEA, 8-Br-cGMP and methylene blue were also observed.

为了研究血管钠肽对人乳内动脉(human intramammary artery, HIMA)的舒张作用及其机制,采用离体血管灌流的方法,观察VNP对内皮完整和去内皮HIMA的舒张作用,以及HS-142-1、TEA、8-Br-cGMP和镁蓝对这一过程的影响。

METHODS: The rabbit hindlimb normothermic tourniquet ischemia model was employed. The tendon on the dorsum of the foot was exposed for observation of microvessels. The responses of arterioles on tendon surface to topical application of 10(-6) mol/L noradrenaline, 10(-6) mol/l acetylcholine (an endothelium-dependent vasodilator) and 10(-4) mol/L nitroglycerin (an endothelium-independent vasodilator) were observed at the period of ischemia and following 30 minutes of reperfusion after 2 hours and 5 hours of ischemia by use of intravital microscopy.

应用兔后肢止血带常温缺血模型及足背肌腱表面微循环观察法,观察肢体缺血 2小时及 5小时再灌注后微动脉对局部滴注血管收缩剂 [去甲肾上腺素(10 - 6 mol/ L ) ]、内皮依赖性血管舒张剂 [乙酰胆碱(10 - 6 mol/ L ) ]及内皮非依赖性血管舒张剂 [硝酸甘油(10 - 4 mol/ L) ]的反应性变化。

Treatment group was treated with valsartan and control group was treated without drugs such as ACEI or ARBs. Pmax,Pd and LADd,LVDs,LVDd were measured and compared before treatment and 6 months' after treatment. Result: There was significant difference in Pd , Pmax and LADd between treatment group and control group .

治疗组给予缬沙坦治疗,对照组给予非血管紧张素转化酶抑制剂类及非血管紧张素受体拮抗剂类降压药治疗,观察药物治疗6个月前后心电图中的Pmax和Pd及超声心动图中的左房舒张末内径、左室收缩末内径、左室舒张末内径的变化。

left ventricle diastolic function can be reflected better by e'/a', e/a, e/e' and ivrt but there still exists localization in evaluating left ventricle relaxing function with these parameters.

e'/a'、e/a、e/e'、ivrt能较好地反映左室舒张功能,但对左室松弛功能的评价仍有局限性,应用无创的颈动脉w2评价左室舒张功能值得做更进一步的研究。

It was suggested that aging did not only influence diastolic filling period, but also influence STI. 3. With increasing age, whether at rest or during exercice, fractional shortening of minor semiaxis, mean velocity of circumferential fiber shortening, cardiac index and ejection fraction did not change, but immediately post pacing, PEP prolonged and PEP/ LVET increased in elderly group and did not change in young group. It was suggested that STI was sensitivity in detecting systolic function of LV. 4. There was a good correlation between aging and decreased compliance and diastolic function of left ventricle which was manifested by a reduction of early diastolic peak folw velocity, time-velocity integral of early diastole, 1/3 filling fraction (1/3FF)(r=-0.958,-0.875 and -0.937, P<0.01~0.001) and a significant compansatory increase in peak flow velocity of atrial contraction, time-velocity integral of atrial contraction, the ratio between APFV and EPFV and the ratio of ATVI and Total TVI (r=0.958, 0.956, 0.966 and 0.986, P<0.001) and the prolongation of Dec T and RFP with increasing age. It was particularly true for the subgroups above the age of 50 years.

静息状态下收缩时间间期与年龄无相关性,负荷后即刻,老年组射血前期延长(P<0.05),射血前期与射血期比值加大(P<0.05),青年组无变化,提示年龄因素亦影响STI,但由于静息状态下得到代偿,STI变化往往表现不明显。3、静息及负荷状态左室短轴缩短率、平均周径缩短率、心指数及射血分数均不随年龄增长而变化,而负荷后即刻老年组PEF延长,PEP/LVET加大,提示STI是检测左室收缩功能的敏感指标。4、随年龄增长,心房收缩期充盈峰值流速、流速积分、充盈分数及心房收缩期与舒张早期充盈峰值流速之比值显著增高(r=0.958、0.956、0.986及0.966,P均<0.001),舒张早期充盈峰值流速及流速积分、1/3充盈分数(1/3FF)下降(r=-0.958、-0.875及-0.937,P<0.01~0.001)。

Objective: To investigate the changes of vasoconstrictor and vasodilator functions of isolated thoracic aorta in the rats with obstructive jaundice, so as to study the mechanism for the functional changes of the aorta in rats with obstructive jaundice.

目的:研究阻塞性黄疸大鼠离体胸主动脉收缩及舒张功能的变化规律,探讨高胆红素血症导致阻塞性黄疸大鼠离体胸主动脉收缩及舒张功能变化的可能机制。

The endothelium-dependent vasodilation is impaired in patients with hypertension and the high-frequence ultrasound can be used to detect endothelial dysfunction.

高血压患者存在血管内皮依赖性舒张功能失调,高频超声能准确可靠地检测血管内皮依赖性舒张功能。

Furthermore, a novel EDRF-dependent and indomethacin-resistant cAMP response may contribute to the CGRP-induced vasodilation in rat aorta.

而且可能有一个新的依赖于内皮存在的舒张因子通过cAMP反应机制而诱发CGRP对主动脉的舒张

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