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We also found that FHL2 is important in the regulation of vasomotor tone, or the contraction and relaxation of muscles in the blood vessel.

Hata说,我们已经发现FHL2是调节血管紧张性或收缩和舒张血管肌肉的重要蛋白。

Methods:Indexes of left ventricular diastolic function in 20 DCM patients and 20 normal subjects were measured by echocardiography and radionuclide ventriculography.

用超声心动图和放射性核素显像对20例DCM患者和20例同龄正常人的左室舒张功能进行对照分析。

Left ventriculography ; Echocardiography ; Systolic function ; Diastolic function

左室造影;超声心动图;左心室收缩功能;左心室舒张功能

METHODS 99 cases with isolated RCA stenosis confirmed angiographically were grouped in terms of severity and location of RCA lesions. Their left ventricular ejection fraction, left ventricular end diastolic pressure measured by ventriculography were compared with those of the control group with no significant coronary lesions.

将冠状动脉造影证实为单纯RCA狭窄的患者99例,按不同狭窄程度、不同狭窄节段和不同冠脉优势型进行分组,并与494例无冠状动脉狭窄的对照组比较,经左心室造影测定的左室射血分数和左室舒张末压。

Methods:to analyze electrocardiogram,echocardiogram,left ventriculography,nuclear magnetic resonance results of 13 cases with ahcm.results:12 cases had apical wall thickening in echocardiogram, 3 cases had a "spade-like" configuration on left ventriculogram, 7cases were misdiagnosed as coronary heart disease initially.conclusion:ahcm is easy to be misdiagnosed as coronary heart disease, echocardiogram plays important role in the diagnosis of ahcm, in patients with suspicion of ahcm and inadequate echo images, the use of contrast echocardiography or mri should be considered.

对13例ahcm的心电图、超声心动图、左室造影及磁共振结果进行分析。结果:13例ahcm中心电图有特征性改变12例,超声心动图提示心尖区增厚12例,左室造影提示舒张期呈"黑桃"形改变3例,初诊误诊为冠心病7例。结论:ahcm易被误诊为冠心病,超声心动图是诊断该病的重要手段,必要时可做心脏超声造影术或磁共振检查。

Left ventricular ejection fraction, percent regional wall motion of infarcted wall, cortina dysfunction score and end-diastolic volume index were calculated by left ventriculography.

经过左心室造影应用面积长轴法计算每例患者的左室射血分数,梗塞区室壁运动百分率,左心室舒张末容积指数及Cortina室壁运动不良积分。

Results: The total saponins of Achyranthes Bidentata Blume not only had significantly inhibitive effects on NE-induced vasoconstriction, but also had direct relaxation effect on vascular smooth muscle.

结果:怀牛膝总皂苷不仅对NE引起的血管收缩有显著的抑制作用,而且还有直接舒张血管平滑肌的作用。

In 66 anaesthetized rats, the effects of local injection of agmatine on femoral, renal, and mesenteric vascular beds were investigated respectively by constant flow perfusion method.

在66只麻醉大鼠,分别采用后肢、肾脏和肠系膜动脉在体恒流灌注法,观察了向灌流环路中直接注射胍丁胺(agmatine, AGM)的血管效应,以所引起的灌流压增减反映血管的收缩和舒张

Results:Normal segment:DEM 8.89±1.21mm,VDEM2.30±0.76cm/s;Hypokinetic segment:DEM 4.56±0.53mm,VDEM 1.89±0.35cm/s;Akinetic segment:DEM 2.13±0.45mm,VDEM 0.95±0.07cm/s.There was a significant overall difference in DEM and VDEM (P0.0001)among wall motion grades.1/3 VDEM was greater than 2/3 VDEM in normal(P0.0001)and hypokinetic(P0.05)segments,though 1/3 VDEM was slower than 2/3 VDEM in akinetic segments(P0.0001).There was also high correlation between 1/3 DEM and 1/3DEMF in both normal(r=0.81,P0.0001,y=0.75x+0.16)and OMI(r=0.91,P0.0001,y=0.74x+0.10)groups.Conclusion:Analysis of color kinesis image can quantitatively assess regional and global diastolic function.

结果:运动正常节段:DEM8.89±1.21mm,VDEM2.30±0.76cm/s;运动减弱节段:DEM 4.56±0.53mm,VDEM1.89±0.35cm/s;运动消失节段:DEM2.13±0.45mm,VDEM0.95±0.07cm/s;三种不同室壁运动状态间的DEM、VDEM均存在显著性差异PDEM显著快于2/3VDEM(4.56±1.18cm/s vs 1.26±0.34cm/s,PDEM略快于2/3VDEM2.14±0.66cm/s vs 1.76±0.47cm/s,PDEM显著低于2/3 VDEM(1.23±0.52cm/s vs 1.37±0.30cm/s,P结论:彩色室壁运动技术能定量评价左室局部和整体舒张功能。

Wenxin capsule can promote endolethial cells releasing CO and synthesing 〓, enhance activity of HO, induce angiectasis through activating guanylic cyclase and adenglate cyclate of intracellar of vessel smooth muscle cell to enhance content of intracellar cGMP and AMP. 3. Wenxin capsule can inhibit releasing of platelet activiting factor 〓 which inhibit platelet aggregation and have antithrombosis function. 4. Wenxin capsule can promote activity of t-PA, reduce activity of PAI-1, strengthen fibrinolytic function, therefore inhibit fibrin disposition. 5. Wenxin capsule can inhibit synthesis of smooth muscle cellular DNA. Its function don't kill it directly but prevent transformation from period Go to peried S. 6. Wenxin capsule is an effective prescription of anti-coronary atherosclerosis atherosis. The results of image pattern analysis tastifies that area of lipid plaque in treating group reduce 54% and 58% in contrast with that in control group. The results of light, electro- microscopy show that structure of endolethial cell and smooth muscle cell in treating group is more integral than that in control group.

其作用机制之一是由于该药具有良好的调脂降脂作用,其不仅能明显降低血清LDL-c及升高HDL-c含量,且能有效阻止TC沉积于血管壁,从而保护内皮细胞结构完整;此外,温心胶囊尚具有明显的抗氧化作用,该药不仅能明显降低血浆LPO含量,且能提高SOD活性,同时其对血红素在细胞内代谢的调节作用也参与了抗氧化过程。2 温心胶囊能明显促进内皮细胞释放CO及合成〓,提高HO活性,通过激活血管平滑肌细胞内鸟苷酸环化酶及腺苷酸环化酶引起细胞内cGMP、AMP浓度增加而引起血管舒张。3 温心胶囊能明显抑制血小板激活因子〓的释放,从而抑制血小板聚集,抗血栓形成。4 温心胶囊能明显提高t-PA活性,降低PAI-1活性,增强纤溶功能,从而抑制纤维蛋白沉积。5 温心胶囊能明显抑制平滑肌细胞DNA合成,其抑制作用不是直接杀伤抑制,而是阻止细胞由Go期向S期转化。6 温心胶囊是抗冠状动脉粥样硬化的有效制剂,图象分析结果证实,该药治疗组脂斑面积比对照组缩小了54%和58%,光电镜结果显示内皮细胞及平滑肌细胞结构较为完整。

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