致病性

Streptococcal pyrogenic exotoxin B is a cysteine protease and carried by every strain of Streptococcus pyogenes. SPE B has been shown to play an important role in invasive group A streptococcal infection.

链球菌致热性外毒素B 是一种cysteine protease，所有A群链球菌都携带致热性外毒素B之基因，在A群链球菌侵入性感染的病程中，致热性外毒素B扮演一个重要的致病角色。

There was big difference among the 22 different materials in the disease resistance. Translocation lines Pm97033 showed the highest resistance in reaction than others. The percentage of diseased root and severed level were 11.3% and 5.4%; substitution lines Wan7107 showed medium resistance to the fungus, the percentage of diseased root and severity level were 21.4% and 10.6%; F5 generation of common wheat with Till showed higher resistance to take-all fungus than the PS progenies of common wheat with Aegilops tauschii or the other common wheat varieties.

菌饼＋菌粒法对宁春4号的致病力明显高于菌饼法和菌粒法，其病根率、严重度和病茎率分别达到100.0%，57.3%和28.6%。22个遗传背景不同的小麦材料间抗病性差异较大，其中小麦－簇毛麦易位系Pm97033的抗病性最强，病根率和严重度分别为11.3%和5.4%；代换系Wan7107次之，病根率和严重度分别为21.4%和10.6%；硬粒小麦－簇毛麦双二倍体(TH1)与普通小麦品种杂交后代的抗病性强于粗山羊草与普通小麦品种杂交后代。

An administrative core unit will be set up with missions of taking care of all the exter

综合而言，以这样一个高度整合的研究计画，从临床、实验及治疗的方向在病人、细菌、细胞层次、和分子层次作系统性的研究，探讨热原性外毒素B及其他致病因子的功能，将会有助於我们对於A群链球菌的致病作用进一步了解，更重要的是这些资讯将会提供临床治疗的新策略。

In Hp positive group, the expression of IL-10 in active gastritis is lower than that in inactive gastritis, which are different with the expression of COX-2 and iNOS, indicating IL-10 is a protect factor in gastritis, but COX-2 and iNOS may relate to pathopoiesis.

Hp阳性组，IL-10在活动性胃炎粘膜组织中的表达低于非活动性胃炎，COX-2、iNOS在活动性胃炎中的表达显著高于非活动性胃炎，说明IL-10在活动性胃炎的发病中可能起保护作用，而COX-2、iNOS可能与致病过程有关。

Spinocerebellar ataxias are a clinically and genetically heterogeneous group of neurodegenerative disorders.

第一部分 SCA家系致病基因定位第一章一个新的SCA家系致病基因定位脊髓小脑型共济失调(spinocerebellar ataxias，SCA)是一种具有高度临床和遗传异质性的神经系统退行性疾病，多呈常染色体显性遗传。

The aim of the present study was to learn the manifestation of which the patients mainly complained of dry mouth, the corresponding pathogenic factors and their correlation, which is helpful to build up a thinking pattern for diagnosis and therapy based on the different clinical manifestations of patients with xerostomia.

本实验试图通过了解口腔门诊以口干为主诉患者的临床表现类型；口干患者的主要致病因素；并寻找口干相关因素与其临床表现类型之间的联系，以期初步建立根据口干患者不同临床表征作出致病因素分析和进行针对性治疗的临床思维模式，并为进一步的分析性研究及试验性研究提供线索。

This Program Project is composed of five projects and an administrative core unit. The specific aims of Project 1 are to study the roles of SPE B, SPE A, M protein and NADase to correlate with bacterial virulence and disease severity in different clinical spectra of GAS infections. We will also study the pathogenic factors of a unique virulent clone of Ml strain caused dominant invasiue GAS disease in Taiwan in the past two years. The effects of penicillin and clindamycin on the production of SPE A and SPE B will also be determined.

本群体计画包含有5个子计画及一个行政核心计画，第一子计画的目标在於研究热原性外毒素A，B和M蛋白及NADase在A群链球菌感染中的功能及其与细菌致病力、疾病严重性的相关性，同时将针对一株最近在台湾造成侵犯性较强的A群链球菌菌株研究其致病因子的异同，并将探讨抗生素penicillin及clindamycin对於热原性外毒素A及B产生的影响。

Among these are genes directly implicated in mendelian disorders, including familial hypercholesterolaemia and insulin-resistant diabetes.

这些基因当中含有单基因疾病致病基因如家族性高胆固醇血症和胰岛素抵抗型糖尿病致病基因。

The apxⅢA gene of Actinobacillus pleuropneumonie was amplified by PCR. The amplified DNA fragment 3 466bp was cloned into pMD18-T. After R.E. analysis and sequencing, the apxⅢA gene in pMD18-T was ligated into pBluescripⅡSK, the recombinant expression plasmid pET-28b/apxⅢA was constructed and analysed with R.E., the protein of apxⅢA gene expressed in E.coli BL21 was detected by Western blotting.

因胸膜肺炎放线杆菌的致病性主要是由毒素决定的，故参照猪胸膜肺炎放线杆血清2型菌株的序列(GenBankL1 2 1 4 5)设计了一对特异性引物，用PCR的方法扩增apxⅢA基因并得到了长 3 466bp的片段，然后将其克隆到pMD 1 8T中，经酶切鉴定和序列分析表明克隆是成功的；再将apxⅢA插入到原核表达载体pET 2 8b后，转化BL2 1 (DE3)，在IPTG诱导下获得高效表达，经Westernblotting检测证实表达产物有活性。

"Inasie candida infections are a major cause of morbidity and mortality in preterm infants," write Paolo Manzoni, MD, from the Sant'Anna Hospital in Turin, Italy, and colleagues from the Italian Task Force for the Study and Preention of Neonatal Fungal Infections and the Italian Society of Neonatology.

都灵的Sant'Anna医院Manzoni医学博士和为&新生儿真菌感染预防和研究&而来的意大利特遣部队的和意大利新生儿学会的的同事们写道：&致病性的念珠菌感染是早产儿中发病率和死亡率的主要原因。&

Do you know, i need you to come back

你知道吗，我需要你回来

Yang yinshu、Wang xiangsheng、Li decang,The first discovery of haemaphysalis conicinna.

1〕 杨银书，王祥生，李德昌。安徽省首次发现嗜群血蜱。