致病

Members individual from family 1 and 2 were found to carry the same pathological mutations as in their proband but without clinical symptoms. They were identified as preclinical patients.

其中家系1和家系2中分别发现1名成员与先证者存在相同位点的NOTCH3基因致病性突变，尚未出现与先证者相应的临床表现，被确定为临床前期患者。

The construction of A83 eukarotic expression vector will play an important pole in researching the effect on HBeAg expression and disease mechanism when A83 mutation in HBV signal peptide reg

HBV A83点突变真核表达载体的构建为体外研究该点突变对HBeAg表达的影响以及HBeAg阴性的乙型肝炎病毒感染的致病机理奠定基础。

The plasminogen/plasmin proteolytic system participates in a wide variety of extracellular matrix degradation.

纤维蛋白溶解系统的胞浆素具有造成细胞间质裂解，产生组织破坏的特性，可能是牙髓致病路径之一。

To confirm the hypothesis that the pathogenic mechanism of air infusion in the circulatory system is not bubble blockade of blood vessels but the consequence of anoxia of the vital organs,different amounts of air were injected into the great sapenous vein of 22 dogs,and then heart rate,cardiac rhythm and bubble sound were monitored with a Doppler probe at the precordial region.

为探讨循环系统内注入空气致病机理，向22只狗大隐静脉内注入不等量空气并在心前区用Doppler监测心率、心律和气泡音。结果发现，维持心前区Ⅳ级气泡音的17只狗，依次出现呼吸和心率加快、心律紊乱、心率缓慢、腹式呼吸加强，其中12只狗继续缓慢注入空气至呼吸停止，任选10只狗胸外按压，8只狗复苏后行为无异常，2只狗未能复活。另2只狗呼吸停止后立即尸检，可见右心房、室、腔静脉和肺血管中有大量气泡。

In the nonallergic form, which is more likely to affect adults, there is no family history of allergy, and the initiating factor may be as simple as a common cold, which develops into paroxysms of wheezing and shortness of breath that may go on for days or months.

成人哮喘病更多以非过敏形式出现。这些人的家庭无哮喘病史，最初的致病原因可能只是简单的感冒。由这种感冒而发展成哮喘的发作，而且呼吸短促，这样的情况可以延续几天到几个月。

There are nine fimbiral operons identified in the genome of Klebsiella pneumoniae NTUH-K2044, a highly invasive strain isolated from Taiwan university hospital, by the HMMER search.

利用生物资讯分析方法HMMER，我们在一株从台湾大学附设医院的病患身上所分离出具有高致病性的NTUH-K0244菌株的基因体中找到九套线毛基因组。

The 59 patient onsets resulted from emotional stimulation, especially "YOU" and "SI" occupying 10.66% and 11.48% respectively.

共有59例发病与情志刺激有关，其中，&忧&&思&致病为最多，分别为10.66%和11.48%。

There were many heterobacteria aid vibrios but few Vibrio parahaemolyticus in living bait. The correlation coefficients between larvae and heterobacteria and vibrios in water were 0.704 and 0.840 in culture system respectively, while the correlation among heterobacteria, vibrios in living bait and larvae, oater were weak or negative.

活饵中异养菌和弧菌数量很大，致病性副溶血弧菌量很低养殖体系中幼体与水体中的异养菌和弧菌的相关系数分别为0.704和0.840；活饵中异养菌、弧菌与对虾幼体和养殖水体相关性很低或呈负相关。

Meanwhile,HDAC1 acetylation level is significantly increased.The overexpression of HDAC1 can promote erythroid cell proliferation and inhibits induced differentiation,the knockdown of HDAC1 or 2 inhibits erythroid cell proliferation and promotes induced differentiation.We also found that HDAC1 affects GATA1 mediated transcription activity.Thus our data revealed that HDAC1 may negatively regulate GATA1 mediated transcription and suggest that the dynamic regulation of GATA1 associated NuRD/MeCP1/HDAC1/HDAC2 complex may determine the onset of erythroid differentiation programs.Moreover,this study will eventually help to design new therapeutic approaches in treatment of leukemia.

研究发现在被诱导分化的小鼠红细胞白血病细胞中与GATA1相结合的HDAC1被乙酰化并失去活性，在血细胞中过表达HDAC1能够促进血细胞的增殖并抑制分化，反之在血细胞中敲除HDAC1或HDAC2能抑制血红细胞的增殖并促进分化，而且HDAC1能够负调控GATA1的转录活性，GATA1与NuRD/MeCP1复合体之间的动态调控，决定血红细胞分化的发生和发展，并为探索白血病的致病机理奠定了理论基础。

Among parasite s, protozoa are usually more pathogenic than nematodes.

在寄生虫中，原虫的致病性往往比线虫的要高。

Do you know, i need you to come back

你知道吗，我需要你回来

Yang yinshu、Wang xiangsheng、Li decang,The first discovery of haemaphysalis conicinna.

1〕 杨银书，王祥生，李德昌。安徽省首次发现嗜群血蜱。