致病

They analyzed 500,000 one-letter ariations, or single nucleotide polymorphisms, in their DNA to look for commonalities. They then confirmed possible culprits in two separate studies of Germans and French-Canadians.

为了找出共同特征，他们分析了他们DNA中500，000个单基因突变或者单核苷酸多态性，最终在关于德国人和法籍加拿大人的两个独立的研究中确定了可能的致病突变。

Testing of relatives at risk: In the newborn sibs of a proband , it is appropriate to either assay ADA catalytic activity or perform molecular genetic testing (if the family-specific disease-causing mutations are known), so that morbidity and mortality can be reduced by early diagnosis and treatment.

对高危亲属的检测：对先证者的新生同胞兄妹，检测ADA催化活性或进行分子遗传学检测（如果已知家族特异性致病突变）都是合适的，这样早期诊断和治疗便能降低发病率和病死率。

The three isolates have four specific replacements in 87 , 88 , 95 , and 119 in S1 hypervariable region, and a unique cleavage site R-X-R-T-G-R in 3' terminal region. These data may be valuable for investigation of molecular basis of the serotyping, tissue tropism and pathogenicity of these virus isolates.

本文的3个分离毒株Q1、J2和T3在S1高变区的87，88，95和119有4个特有的替换，在3'末端有独特的裂解位点R-X5-R-T-G-R，这些结果可能对这些分离毒株的血清型特异序列和组织趋向性和致病性的分子决定区方面的研究有重要的价值。

The three isolates have four specific replacements in 87, 88, 95, and 119 in SI hypervariable region, and a unique cleavage site R-X-R-T-G-R in 3 terminal region. These data may be valuable for investigation of molecular basis of the serotyping, tissue tropism and pathogenicity of these virus isolates.

由于SI蛋白序列99－12川立氨基酸之间的序列可能对病毒的致病性起重要作用，SI蛋白5，高变区（56－69；117－131）与中和表位和血清型密切相关，这些区域在IBV血清型和基因型间起联系作用。

Green Paradise Co., Ltd., of Japan Green Paradise Group, which focused on environmental protection technology development, research and education, the use of biotechnology to deal with recycling industry, bringing together the various research results, applications such as biotechnology and photochemical principles, research and development of a solution to a series of pathogenic Products Building Syndrome.

绿色乐园株式会社，属于日本绿色乐园集团，该集团主要致力于环境保护技术的开发，研究和教育，利用生物技术进行产业循环再生处理，汇集诸研究成果，应用生物技术和光化学等原理，研究开发出了解决致病建筑综合症的系列产品。

The replicon systems are useful tools for the study on hcv pathogenesis, the screening of antiviral drugs and the development of vaccines.

复制子系统的建立对hcv致病机制、治疗药物筛选及疫苗方面的研究具有重要的意义。

The EIAV proviral genomic long-terminal repeat is a eukaryotic promotor, which plays an important regulatory role on transcription and replication of the virus.

反转录病毒前病毒基因组长末端重复序列对病毒复制有重要的调控作用，影响到病毒的繁殖动力学、组织嗜性、致病力等方面。

The EIAV proviral genomic long-terminal repeat is a eukaryotic promotor, which plays an important regulatory role on transcription and replication of the virus.

反转录病毒前病毒基因组长末端重复序列对病毒复制有重要的调控作用，影响到病毒的复制动力学、细胞嗜性、致病力等方面。

The results of this study confirm the instability of prophage, and suggested that the prophage plays important role in the pathogenicity of O157:H7, and in the evolution of pathogenic bacteria.

该研究证实了编码Stx的原噬菌体具有不稳定性，原噬菌体对O157的致病性具有重要作用，也提示原噬菌体在致病菌的进化过程中也具有重要作用。

Clinical evaluations demonstrated familial apical HCM in 4 probands, and in 3 probands disease-causing mutations were identified.

临床评价显示4个患者为家族性心尖肥厚型心肌病，并在3个患者验明致病基因突变。

Do you know, i need you to come back

你知道吗，我需要你回来

Yang yinshu、Wang xiangsheng、Li decang,The first discovery of haemaphysalis conicinna.

1〕 杨银书，王祥生，李德昌。安徽省首次发现嗜群血蜱。