致病

Renal hypofunction is not only a sign of mortality of cardiovascular disease,but also one pathogenic factor among them.

肾脏功能减退不仅是心血管病死率中的一个标志，同时还是其中的一个致病因子。

Paper 2:Mutation analysis of EDA gene in Chinese families with X-linked hypohidrotic ectodermal dysplasiaX-linked hypohidrotic ectodermal dysplasia(XLHED,MIM305100) is a recessive disease characterized by severe hypohidrosis,hypotrichosis and hypodontia.

论文二X连锁无汗/少汗型外胚层发育不良中EDA基因致病突变鉴定X连锁隐性无汗/少汗型外胚层发育不良(X-linked anhidrotic/hypohidroticectodermal dysplasia，XLHED；MIM305100)是无汗/少汗型外胚层发育不良(anhidrotic/hypohidrotic ectodermal dysplasia，EDA)中最常见的一种，约占95%。

Bipolar II Disorder involves Major Depressive Episodes and Hypomanic Episodes. Since a significant portion of those suffering manic depression did not have full manic episodes, the classification was divided into Bipolar I and Bipolar II. However, Bipolar II is often a first step to Bipolar I. Over 5 years, between 5% and 15% of those will Bipolar II will change diagnosis to Bipolar I. Approximately 0.5% of people will develop Bipolar II in their lifetimes.

双极性二型包含重度忧郁症和轻躁症的症状由於有一大部份的躁郁症病人并没有完全的躁症症状，所以躁郁症要分为双极性一型和双极性二型然而，双极性二型常是双极性一型的第一步，经过五年，5% and 15%的双极性二型的病人会转变成双极性一型双极性二型的终生致病率大约为0.5

Gene mapping of a hereditary hypotrichosis simplex family;2. Objective To collect pedigree of hereditary hypotrichosis simplex .

目的 收集一遗传性单纯少毛症家系，通过定位候选克隆技术，识别该病的致病基因，以阐明遗传性单纯少毛症的发病机制。

Marie Unna hereditary hypotrichosis is an autosomal dominant hair loss disorder,with the affected individuals usually born with little or no hair,and coarse twisted hair growth on the scalp in early childhood.

国际上将MUHH基因座定位于人染色体8p21区域，但对此区域中与毛发周期密切相关的Hairless基因编码区进行突变筛查时都没有发现任何致病性突变。

Objective To introduce the clinical olwer, ation of cutaneous distribution of the ilioinguinal nerve on the labia major and diagnosis and local injection treatment of its neuralgia.

目的 介绍髂腹股沟神经在大阴唇皮肤分布区的临诊观察及神经痛的诊断与局部注射的治疗方法方法选择门诊确诊为髂腹股沟神经痛或股后皮神经痛累及其会阴支的女性患者共28人计31侧，细查计刺痛觉的变化以确定诊断及两神经分布区的范围采取强的松龙25mg+2％利多卡因或1％普鲁卡因5～10ml注射最大可能致病部位结果注射后数分钟检查麻醉范围。

Nucleoprotein is also a major immunogenetic antigen for SARS; however, several tests have shown that N protein had the reactivity with other coronavirus positive sera. It is therefore an advantage of S protein as recombinant target antigen for SARS serum diagnosis compared with recombinant N protein. Moreover, S protein has been shown to be the major antigenic determinant that induces neutralizing antibodies and protective immunity to SARS-CoV, so it is also important in designing SARS genetic engineering vaccine.

SARS-CoV S 蛋白由1255 个氨基酸组成，体外表达如此大的蛋白很困难，而且表达蛋白的可溶性不高；其次，实验已经证实，全长S 蛋白含有大量无关的表位，致使表达的全长S蛋白对SARS 阳性血清的检出率低于S 蛋白片段；另外作为疫苗研究，S 蛋白上大量无关表位作为异体蛋白进入体内，会引发机体的过度免疫反应，这也是SARS-CoV 可能的致病机理之一。

3Genetic factors play a major role inthe control of immune regulation,such as the expression of cytokines.An analysisof TNF〓 gene polymorphism in IgAN and HSP nephritis is beneficial to better un-derstanding of immunogenetic abnormalities in these diseases.But further inves-tigation on a large scale is necessary in order to find out the susceptibility genes orthe markers for a closely-linked susceptibility locus.

某些免疫相关基因是细胞因子表达、调控的决定因素，本实验通过〓基因多态性分析对部分肾小球疾病的遗传背景进行了有益的探索性研究，但是要最终找到致病基因或者连锁遗传标志，尚有待进一步的大规模研究。

Covers cells and tissues of the immune system, lymphocyte development, the structure and function of antigen receptors, the cell biology of antigen processing and presentation including molecular structure and assembly of MHC molecules, the biology of cytokines, leukocyte-endothelial interactions, and the pathogenesis of immunologically mediated diseases.

课程涵盖免疫系统的细胞和组织，淋巴球的发育过程，抗原受体的结构和功能，抗原反应过程的细胞生物学以及抗原的呈现，其中包括MHC分子的结构与组合，细胞激素的生物学，白血球和内皮组织的互动关系，以及免疫相关疾病的致病机转。

A possible mechanism of osteonecrosis may be intraosseous fat embolism leading to focal intravascular coagulation and osteonecrosis.

可能的致病机转为骨头内脂肪栓塞导致局部血管内凝集而骨头坏死。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。