致病

According to the eresults described above, we preliminarily suggested that the pathogenic mechanism of Clonorchis sinensis may be related to activation of PKC and increased expression of γ-GTase.Praziquantel, not only can destroy adult worm directly, but also regulate γ-GTase activity. Furthermore, by inhibiting the expression of PKC, Praziquantel can elevate the repair of cells and reduce tumorigenesis. Further investigations are needed to dissect the detailed mechanism.

根据以上的实验结果，我们初步推测中华肝吸虫的致病机转可能和 PKC 的活化作用、γ-GTase 活性的表现有关，而驱虫药 Praziquantel 治疗中华肝吸虫，除了直接破坏虫体外，也可能会抑制 PKC 的表现进而调节γ-GTase 的活性，藉以提升细胞的免疫修复，而降低癌化的产生；唯其详细机转有待进一步探讨。

The purpose of this study was to investigate the pathogenic mechanism of Clonorchis sinensis. Male wistar rats were utilized as experimental animals and randomly divided into three groups. Two of them, which were divided into drug-treated and control groups were fed with metacercaria of Clonorchis sinensis.

为探讨中华肝吸虫的致病机转，本研究以wistar 雄性大白鼠为实验动物，研究分实验组及正常组，实验组以口餵管餵食中华肝吸虫囊蚴后再公为投药组及不投药组，投药组於感染后十二周以Praziquantel处理，不投药组仅给予生理食盐水。

The high prevalence of resistance to chicken sera, fimbriae F1, temperature-sensitive hemagglutinin in high pathogenic isolates suggested importance of these phenotypes in the pathogenesis of colibacillosis.

结果显示禽源大肠杆菌的致病性与其血清耐受能力、鸡红细胞MSHA菌手的表达和温度敏感性血凝素的表达呈一定的相关关系。

Commensally bacteria help keep pathogenic bacteria at bay, and in the late 1990s new research was beginning to show that symbionts also contribute to the development of the intestinal architecture.

细菌共生帮助保留致病性细菌在海湾，并且在20世纪90年代末期新的研究开始表示， symbionts也对小肠建筑学的发展有用。

With the comparition of the two groups, the conclusion can be drawn that the p80 protein expressed by the plasmid pEGFP-P80 cannot cause the detectable depression of activity of PK-15 cells.

结果表明，利用pEGFP-P80 重组表达质粒在PK-15 细胞中表达出的p80 蛋白未对宿主细胞有明显的致病变作用。

From the 105 isolates, we choosed 20 isolates that had good conidia and strong pathog enic ability.

从供试的105个菌株中，筛选了20个产孢量好、致病力强的菌株进行了继代培养。

Six pathogenetic fungi were isolated from infected leaves of chrysanthemum. Morphology of six isolates conidia was investigated for identification.

利用组织分离法，从自然发病的菊花病叶上分离了6株对菊花具有致病性的病原真菌。

In the mortality studies, 8 isolates infected more than 80% of the grubs, another 65 isolates infected more than 50% of the grubs and the rest of the isolates had a low level of pathogenicity with 107 conidia/mL concentration.

於致死试验中，有8个分离株感染了超过80%的蛴螬，另有65个分离株感染了超过50%的蛴螬，而其余浓度为10^7 conidia/mL的分离株致病力低。

The above results can summarize the function of STK1: insignificant effect on mycelium development and growth but related to the pigment accumulation in hypha; key factor regulating the conidial development; related to the HT-toxin activity and pathogenicity.

结论推测，STK1基因对玉米大斑病菌菌丝的生长发育没有影响，但可能与菌丝中色素等物质的积累有关，并调控病菌分生孢子的发育、HT-毒素的活性和致病性。

Strains YL001 and YL002 formed a monophyletic clade with strains of X. nematophilus with sequence homology outweighing 99% and the sequence homology to genus Photorhabdus outweighing 94%. The lag, logarithmic, stationary and contabescence phase of the two bacteria were 0-6, 6-18, 18-66 and 66 h respectively; pH of strains YL001 and YL002 reduced to 5.70 and 5.56 at 12 h, respectively, and then rose gradually to 7.74 and 8.07 respectively when culture finished. Glucose content reduced quickly during 0-18 h, and then kept stable. Amido nitrogen content reached the lowest at 12 h and then rose slowly. YL001 exhibited the highest inhibitory effects at 54 h and YL002 exhibited highest inhibitory effects at 42 and 66 h respectively on B. cirerea and B. subtilis. Strains YL001 and YL002 belonged to X.

YL001和YL002菌株与嗜线虫致病杆菌种内菌株形成一个类群，序列同源性大于99%，与发光杆菌属内菌株的序列同源性大于94%。2菌株的延缓期、对数生长期、稳定期和衰亡期分别为0~6，6~18，18~66和66 h；培养12 h后，YL001和YL002菌株发酵液的pH值分别降低至5.70和5.56，此后逐渐上升，至发酵结束时其pH值分别为7.74和8.07；培养0~18 h时2菌株发酵液中还原糖含量迅速降低，此后保持稳定；12 h时氨基氮含量达到最低，此后开始缓慢上升；YL001菌株培养54 h后及YL002菌株培养42和66 h后，其对番茄灰霉病菌和枯草芽孢杆菌的抑制作用最强。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。