致病

The results showed that when the proportion of the resistant subpopulation within the h-VRSA was low, te level of the toxic factor and its pathogenicity to animals had no difference from that of the standard strain. If proportion of the resistant subpopulation increased the level of coagulase and lecithinase changing from positive from negative and the ring of hemolysis disappeared. The speed of proliferation of the organisms in the animal slowed down and the LD50 increased.

结果 当试验菌株中耐药亚群的比例较少时，其毒力因子及动物致病性检测结果与金葡菌标准菌株无显著差异；随着试验菌株中耐药亚群的比例增加，表现为血浆凝固酶、卵磷脂酶由阳性转为阴性，血琼脂平板上溶血环消失，细菌在动物体内增殖速度减慢，对动物的半数致死量(LD50)增加。

The liqase was positively controlled by HAI and AI-2 to some extent. The lecithinase was negatively controlled by HAI-1, and the hemolysin was negatively controlled by both HAI-1 and AI-2. Special primers of luxS gene were designed from the luxS gene sequence of V. harveyi obtained from the GenBank, and the gene was amplified from a pathogenic strain V. harveyi VIB645 by PCR. The luxS gene was cloned to a cloning vector pUC, and was sequenced. It was found that the open reading frame is 519 bp. The similarity of the luxS gene from V. harveyi VIB645 to the published sequence of V. harveyi strain in GenBank was only 90%.

从GenBank中获取哈维氏弧菌中编码AI-2合成酶的luxS基因序列设计一对特异性引物从哈维氏弧菌VIB645中PCR扩增luxS基因，将luxS基因克隆于pUC载体并测序，发现其与GenBank中已发表的哈维氏弧菌的luxS基因序列相似性为90%，证明LuxS/AI-2系统在哈维氏弧菌不同的菌株中的具有一定的特异性，推测LuxS/AI-2系统可能与哈维氏弧菌的致病性或发光现象有关。

Objectives: Leptospirosis, caused by the pathogenic leptospires, is one of the most widespread zoonotic diseases as known.

目的：钩端螺旋体病是一种由致病性钩端螺旋体引起的世界范围内广泛流行的人兽共患性传染病。

Gregory House is a doctor 』『 atypical, he never wore robes, always bearded, leaning on a cane, eating jelly beans all day long like a knock painkillers; he is convinced that everyone is lying 『』, or trying Avoid contact with patients or their families to meet, or a mockery of his best satire can be, even for patients acrimony; his diagnostic method deviant, repeatedly instructed subordinates three little ducks 』『 house-breaking patients into the room to find the source of illness; not hesitate to take extreme experimental treatment, the patient or their own force to the edge of death, is to unlock a Road for the difficult medical problem.

Gregory House是一名『非典型医生』，他从不穿白大褂，永远是胡子拉碴，拄着一根拐杖，成天吃糖豆似的磕止痛片；他坚信『每个人都说谎』，要么竭力避免与病人或家属见面，要么极尽讽刺嘲弄之能，甚至对病人恶言相向；他的诊断方式离经叛道，多番指示手下三只『小鸭子』破病人家门而入，寻找致病源头；不惜采取极端的实验性治疗方案，把病人或自己迫向死亡边缘，为的是解开一道道棘手的医学难题。

Yet averages between cities had served as the main measure of the long term effects of pollutants.

然而，调查是以成时间的平均污染物所产生的致病效果作为长期的研究源。

Many studies have reported that Klebsiella pneumoniae is associated with ankylosing spondylitis but the mechanism of pathogenesis is remained unclear. The endoplasmic reticulum stress would be induced upon exposure of decapsulated KP in HLA-B27 expression B lymphoblast CA46 cells and non-HLA-B27 expression U937 monocytes. Our previous studies demonstrated that decapsulated KP could up-regulate BiP/Grp78 and calreticulin expressions in a dose- and time-dependent manner. We screen more than 60 kinds of traditional herbs and bioactivity agents and we found that berberine,taurine,extracts of Andrographis paniculata Nees.

许多研究指出克雷伯氏肺炎杆菌和僵直性脊椎炎有相当的关系，但是致病机制仍然不是很清楚，因此我们使用去荚膜克雷伯氏肺炎菌来诱发表现HLA-B27的CA46 B淋巴球母细胞、不含HLA-B27的U937单核球细胞可以产生内质网压力，我们先前的实验指出，随著剂量增加，去荚膜克雷伯菌能够过度调控内质网压力指标蛋白质BiP和Calreticulin表现增加。

Pathogenic mechanism is mainly by inhibiting bone marrow and megakaryocyte function, direct destruction of platelets and induce allergic work.

致病机制主要是通过抑制骨髓和巨核细胞的功能，直接破坏血小板和诱导机体变态反应起作用。

The result is identical basally with past one about pathogenicity mensuration.

该分类结果与以往的致病性测定小种划分基本一致。

To ensure the system is not re-infected with pathogenic micro-organism, the filling water must be reliablydisinfected by AQUADES-UV technology!

要确保那系统不会再受到致病微生物的感染，所有盛水必须利用有可靠性的AQUADES-UV 紫外线技科来消毒。

When I trained as a microbiologist around the year 2000, the focus was still on pathogenic bacteria.

在年-2000附近，当我训练了作为微生物学家，焦点仍然在致病性细菌。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。