致死的

The results indicated that the treatment of irradiation restrained the growth and differentiation of protocorm, especially to roots.The LD50 is 67.23Gy, because the protocorm is a integrate embryoids and higher tolerance was found. Ploidy analysis showed that most of aberrant seedlings go with the change of DNA and they were not euploid. When the plants trearted by irradiation, some of aberrant seedlings appeared stem forfication, and leaves appeared chlorophyll-deficient or green-white.,probably due to some genes' expression or closing.

结果表明：辐照处理对种胚原球茎的生长和分化有抑制作用，尤其是对根的抑制更为明显；由于种胚原球茎的完整性好，耐受性强，其辐照半致死剂量(LD50)为67.23Gy；流式细胞分析表明，大多数外部形态发生改变的植株其细胞内DNA的倍性发生了改变，出现相当多的非整倍体；此外，辐照产生的变异苗出现茎分叉、叶片缺绿或白绿相间等现象，可能是由于某些基因的表达与关闭引起的。

The results showed as follows: 1 Extraction of gelsemium total alkaloids. Total alkaloids were extracted with 95 per cent ethanol. The extract rate was 0.519 per cent and the extract purity were 88.02 per cent and 87.38 per cent; Total alkaloids were extracted with chloroform .The extract rate was 0.416 per cent and the extract purity were 89.02 per cent and 94.52 per cent. 2 Isolation of gelsemium total alkaloids with TLC. Total alkaloids contained five or more alkaloids. The optimal developing agent was chloroform :methanol :ethyl acetate(9:l:0.3),the optimal eluent was methylene chloride:methanol(92:8). 3 Isolation of total alkaloids with column chromatography. Alkaloid A and alkaloid B were obtained, alkaloid B was identified as koumine.

研究结果如下：1、钩吻总碱的提取：用95％的乙醇提取钩吻生物碱提取率为0.519％，其提取物纯度为88.02％、87.35％；用氯仿提取钩吻生物碱提取率为0.416％，其提取物纯度为89.02％、94.52％。2、钩吻总碱的薄层层析分离：总碱中含有5种或5种已上的生物碱；氯仿：甲醇：乙酸乙酯(9：1：0.3)是最佳薄层层析的展开剂；二氯甲烷：甲醇(92：8)是柱层析的最佳洗脱剂。3、钩吻总碱的柱层析分离：共得到两种钩吻生物碱单体成分碱A和碱B，碱B为钩吻素子，碱A可能是钩吻素甲。4、钩吻总碱的急性毒性试验：钩吻总碱小鼠腹腔注射的半数致死量LD_(50是：7.38mg／kg，95％的可信限范围为：6.67mg／kg～7.94mg／kg。

In cells treated with sublethal doses of UVordoxorubicin,Pirh2 abrogates Axin-induced p53 phosphorylation at Ser-46 catalyzedby HIPK2,through competing against HIPK2 binding to Axin.

在亚致死剂量的紫外辐射或是柔红霉素的处理下，Pirh2通过竞争HIPK2与Axin的结合而阻碍Axin介导的由HIPK2催化的p53的46位氨基酸的磷酸化。

Results:weijian obviously shortened the latent period of erection in castrational rats after electric stimulus and the latent period of coitus in castrational mice,increased coitus times in castrational mice,increased the appearance rate of sperm suppository in copulated female mice. the acute toxicity tests showed that the half lethal dose(ld50) of weijian was 901.53 mg/kg and 319.60 mg/kg, the long-term toxicity tests showed that large dose of weijian slightly increased the level of glutamic pyruvic transaminase and decreased the glucose,triglyceride and cholesterol of blood, while had no effects on other biochemical factors.

结果： 伟剑能明显缩短去睾丸大鼠的电刺激阴茎勃起潜伏期，明显缩短去睾丸小鼠的性交潜伏期，并增加去睾丸小鼠的性交次数，增加交配后雌性小鼠的精栓出现率；急性毒性试验测得伟剑的口服半数致死量（ld50）为901.53 mg/kg，腹腔注射的ld50为319.60 mg/kg；长期毒性试验研究表明该药在大剂量时可轻度升高谷丙转氨酶，轻度降低血糖、总胆红素及胆固醇，而对其他血液生化指标无影响。

"With every car bomb that takes civilian toll, every insurgent's bullet that finds it mark, every roadside explosive that maims or kills one of our own brave men and women in uniform, the sacrifices mount and the result is anything but satisfactory."

每一次汽车炸弹的引爆都会导致平民的伤亡，每一颗叛乱分子的子弹都能找到它的目标。每一次路边的爆炸袭击都会使我们勇敢的军人伤残或致死。来自报道中牺牲的数字就表明结果并不能使人满意。

Results: Of the 709 interviewee, 574(80.96%) recognized rabies as a fatal disease, 156(22.00%) disregarded the threat posed by pet bites, 446 (62.91%) would seek medical assistance once bit, while 121(17.07%) reported treatment of wounds using improper, thumbnail approaches. Prevention was observed based on doctor's advices in all of 9 degree Ⅰ exposers (100.00%), 76 of 91 degree Ⅱ exposers (83.52%) and 32 of 212 degree Ⅲ exposers (15.09%).

结果：有80.96%(574/709)的被调查者知晓狂犬病是一种致死性疾病，22.00%(156/709)的被调查者对家养动物致伤表示无所谓、不用治疗的观点，认为只要致伤需就诊者占62.91%(446/709)，用土方法等不正确方法处理伤口者占17.07%(121/709)；100.00%(9/9)的Ⅰ级暴露者，83.52%(76/91)的Ⅱ级暴露者和15.09%(32/212)的Ⅲ级暴露者完全按照医嘱进行了预防治疗。

Methods:(1) Dissoluble PGN and CpG DNA were immobilized onto the surface of biotin cuvette for establishing target. Another effective tracking approach was established by immobilizing Escherichia lipid A F583 onto the surface of Non-derivatised cuvett. The biosensor technology was applied to screen anti-inflammatory TCM targeting on three key molecules.(2) The active compositions were isolated by AB-8 macroreticular resin from lycium bark. After the activities of compositions were evaluated, the most effective compositions was confirmed. In vitro, the affinities of different concentrations composition E binding with PGN, CpG DNA and lipid A were measured separately. The effect of composition E on vigor of RAW264.7 cells were tested by MTT and CCK-8, and its inhibition on TNF-α, which was released from RAW264.7 cells induced by PGN, CpG DNA and LPS, was also tested by ELISA. In vivo, murine sepsis models were made by intravenously heat-killed E.coli and heat-killed S.aureus, then protection of composition E on mice sepsis model were observed.

(1)将PGN及CpG DNA包被于生物素样品池，将lipid A包被于非衍生样品池，分别建立以PGN、CpG DNA及lipid A为靶点的技术平台，对114种抗炎中药水提物进行筛选、评价其活性物质含量，并评估出针对上述三种病原分子均具有较高结合活性的中药；(2)利用生物传感器跟踪检测技术、大孔吸附树脂分离技术，从地骨皮中定向分离与PGN、CpG DNA及lipid A均具有较高亲和力的活性组分；在体外实验中，测定不同浓度活性组分与PGN、CpG DNA及lipid A亲和力；MTT法及CCK-8法检测活性组分对RAW264.7细胞活力的影响；ELISA法检测活性组分对PGN(2μg/ml)、CpG DNA(10μg/ml)及LPS(100ng/ml)刺激小鼠RAW264.7细胞分泌TNF-α的抑制作用；在体内实验中，采用尾静脉注射致死剂量热灭活大肠杆菌和热灭活金黄色葡萄球菌，建立细菌脓毒症小鼠模型，观察活性组分对脓毒症模型小鼠的保护作用。

"In the next 25 years, AIDS will and heart disease, stroke and together referred to as the world's top three killer diseases, and for patients suffering from AIDS treatment to save at least 3,000,000 / year of life, the figure highlights AIDS The importance of treatment,"Pfizer Perros Manos on behalf of the view that AIDS can be treated as chronic diseases to treat, in accordance with the current development of Chinese medicine, patients with a medicine every day to eat only get relief, which compared with the previous day Eat more than 10 tablets of drugs to more effectively and reduce the side effects of drugs on the human body.

&在今后25年，艾滋病将和心脏病、中风一起并称为世界上三大头号致死疾病，而对身患AIDS的病人的治疗，至少可以挽救300万/年的生命，这一数字突出了艾滋病治疗的重要意义&，辉瑞制药代表Perros Manos认为，艾滋病可以被当作慢性疾病来治疗，按照现在的医药发展，患者每天仅吃一粒药就能得到救助，这比起以前每天吃十几粒药要更加有效且降低了药物对人体的副作用。

Results showed that there were significantly positive linear correlations between the toxic effects（probits of mortality and inhibition rate） of chlorpromazine on the two aquatic organisms and the concentrations of chlorpromazine, and the toxic intensity became higher as the exposure time increased. The LC50 values of chlorpromazine acting on Carassius auratus in 24, 48 and 96h were 1.11, 0.43 and 0.32mg·L-1, respectively; and its safe concentration for Carassius auratus was 19.5μg·L-1. The LC50 and EC50 （50% of the tested Daphnia magna inhibited） values of chlorpromazine acting on Daphnia magna in 24h were 0.65 and 0.57mg·L-1, and the LC50 and EC50 values in 48h were 0.36 and 0.28mg·L-1, respectively. Thus, chlorpromazine have high toxicity to Carassius auratus and Daphnia magna, and the latter is more sensitive to chlorpromazine.

结果表明：氯丙嗪对两种水生生物的毒性效应（致死率、抑制率概率单位）均与其浓度呈显著线性正相关关系（p.05），且毒性强度随作用时间的延长而增加；氯丙嗪对鲫鱼的24、48和96h的半致死浓度（LC50）值分别为1.11、0.43和0.32mg·L-1，通过计算求得氯丙嗪对鲫鱼的安全浓度为19.5μg·L-1；氯丙嗪对大型蚤的24h LC50值为0.65mg·L-1，24h EC50值（使50%受试大型蚤活动受抑浓度）为0.57mg·L-1；48h LC50值为0.36mg·L-1， 48h EC50值为0.28mg·L-1；对鲫鱼和大型蚤而言，氯丙嗪属极高毒性物质，大型蚤对氯丙嗪的敏感性大于鲫鱼。

Under high temperature stress, the former is higher than the later in the speed of leaf starch grain degradation, metabolism and transformation into carbohydrate which can be transported outside, while lower in storage starch consumption in the leaf sheath, this mechanism is important to rice to spend temporarily high temperature hurt. The cell membrane thermal stability expressed by the thermal death time at 50℃ could be used as an accurate and handy physiological index to rice breeding for heat tolerance fitting individual plant selection and identification at grain-filling stage in future.

在高温胁迫处理下，叶片中淀粉粒降解代谢转化为可外运碳水化合物形式的速度是耐热品种大于不耐热品种，而消耗叶鞘中贮藏淀粉的速度则小于不耐热品种，这种机制对于水稻度过暂时性的高温热害具有重要意义。50℃热致死时间所表示的细胞膜热稳定性可作为今后水稻灌浆期耐热性育种中适合单株选择鉴定的简便、准确的生理指标。

Breath, muscle contraction of the buttocks; arch body, as far as possible to hold his head, right leg straight towards the ceiling (peg-leg knee in order to avoid muscle tension).

呼气，收缩臀部肌肉；拱起身体，尽量抬起头来，右腿伸直朝向天花板（膝微屈，以避免肌肉紧张）。

The cost of moving grain food products was unchanged from May, but year over year are up 8%.

粮食产品的运输费用与5月份相比没有变化，但却比去年同期高8％。