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致死剂量

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Serious convulsion is usually followed by cardiotoxicity induced by local anesthetics. The ratio of medial lethal dose (CD50) and median convulsant doses (LD50) is usually used to assess the comparative safety of local anesthetics.

中枢神经系统明显的神经毒性作用往往是心脏毒性产生的先兆,半数致死剂量和半数致惊厥剂量的比值能够反应局麻药的安全性。

Effects of gamma irradiation on shoot regeneration from leaf and bud growth in vitro of strawberry 1 The leaf was very sensitive to the gamma irradiation, and 'Toyonoka' was more sensitive than 'Akihime'. The LD50 (50% decrease of generation) of strawberry leaf was between 10 and 20 Gy. 2 Strawberry leaves were inoculated in vitro at 8 d-15 d after gamma rays irradiation, and the shoot regeneration rate from of 'Toyonoka' increased at 10 Gy and almost no difference from 20 Gy to 40 Gy. The positive effect dose for 'Akihime'.was from 10 Gy to 30 Gy, however, 40 Gy decreased shoot regeneration rate.

2.60Co γ辐射对不同品种草莓离体叶片再生及芽生长的影响 1)叶片对辐射敏感,叶片再生的半致死剂量为10 Gy-20 Gy,'丰香'品种比'章姬'品种敏感; 2)辐射后8 d-15 d接种,'丰香'叶片的不定芽再生率在剂量10 Gy呈上升趋势,而其他剂量则几乎未见有变化,'章姬'在剂量10 Gy-30 Gy,叶片的不定芽再生率提高较大,40 Gy仍表现轻微下降; 3)适宜的辐射剂量对草莓试管苗增殖有促进作用。

The inhibition effects became stronger with the increase of the irradiation dose. Semi-lethal dose of Ailanthus altissima Swingle seeds was 50Gy. 50~75Gy could be considered as the proper dose for seed irradiation treatment of Ailanthus altissima Swingle.

结果表明:辐照抑制了种子的萌发,成苗率下降,幼苗生长受到抑制,且随着剂量的增加,抑制作用增强;椿树种子的半致死剂量为50Gy,适宜辐照剂量为50~75Gy。

Genistein was added by different does to the feedstuffs, and its influence on the 30-day survival rate and on the antioxidan. hematogenic and immune system in mice were investigated.

本研究以~(137)Cs作为放射源,以7.5Gy的致死剂量和4.0Gy的中等辐射剂量一次性全身照射小鼠,分别观察补充不同剂量的Gen对电离辐射后小鼠活存率和抗氧化系统、造血系统、免疫系统功能的影响。

Hepatic and renal functions,and tissue biopsy were measured in rats with therapeutic,toxic and lethiferous dose treatment after a period of time.

分别测定治疗剂量、中毒剂量、致死剂量组小鼠在用药一段时间后的肝肾功能,并进行组织病理学检查。

In result 2.5% of the rats got slight hepatic enzymes increase, and 6.25% of the rats got slight fat degeneration for hepatic tissue specimens. Most of the rats with abmormal results occurred in the toxic and lethiferous group, and there was the increasing tendency with the increase of dose. There were no changes for renal function and tissue biopsy.

实验结果显示共有2.5%的小鼠出现了轻度的肝酶升高,组织病理有6.25%的小鼠肝组织出现了轻度的脂肪变性,结果异常的小鼠绝大多数发生于中毒剂量及致死剂量组,且有随着剂量增高而增加的趋势;肾功能及组织病理无明显改变。

Take the blood specimen to measure the hepatic and renal function and the tissue biopsy after the active and motive abnormities called toxical manifestation such as posture changes, abnormal sound, uneasiness, quiet, thrill, ataxia, convulsion and so on with toxic dose. Measure the tissue biopsy after death with lethiferous dose. If no toxicity or death occur after the experiment of 12 weeks, measure the hepatic and renal function and the tissue biopsy. There was no rat which had the toxical manifestation such as active or motive abnormities and 3 rats died because of environment or others after the experiment of 12 weeks.

实验中分别测定治疗剂量组小鼠在用药4周,8周,12周后的肝肾功能,并进行组织病理检查;中毒剂量组小鼠在出现行为、动作异常,如改变姿势、叫声异常、不安、安静、震颤、运动失调、惊厥等中毒表现时,取血液标本测定肝肾功能,并进行组织病理检查;致死剂量组小鼠发生死亡后进行组织病理检查;若12周实验结束时无小鼠出现中毒表现或死亡,则取血液标本测定肝肾功能,并进行组织病理检查。12周实验结束时,无小鼠出现动作、行为异常等中毒表现,有3只小鼠因为环境或其它原因发生死亡,病理检查结果正常。

After twenty-one days, they were challenged by white spot syndrome virus. The mortalities of crawfishes after challenged with WSSV of the same dilutions were negatively correlated with the the dose of Ig-Guard, that is, along with the increase of the dose of Ig-Guard, their mortalities were decline; The LD50 of the immune group was higher than the control group, further more, along with the increase of the dose of Ig-Guard, the effectes were obvious.

注射相同稀释浓度的螯虾,其死亡率与添加Ig-Guard的剂量呈负相关,即添加Ig-Guard剂量越高,其死亡率越低;免疫组螯虾的半数致死剂量(LD50)高于对照组的半数致死剂量,而且其效果随着免疫剂量的增加而越来越明显。

The seeds of Adzuki bean were irradiated by 60 Co γ ray of 0~700Gy.The results showed that:(1)The sub\|lethal dose(LD 50 )was 389Gy and the early seedling leaf at M\-1 showed incised,chlorotic,yellow,mosaicand curly edge.The absorbed dose was related with the rate of misshaped leaf.Chromosomal aberration, chromosome bridge and fragment of M\-1 in the tip were observed.If the seed was irradiated with 400Gy,the rate of abnormal cell at the root was more than 10%.The relationship between pollen fertility and irradiation dose was negative correlated.

本试验研究结果表明:60 Coγ射线辐照小豆种子的半致死剂量平均为 3 89Gy ,且M1生长初期叶片性状有明显的叶面缺刻、叶色缺绿、叶形不对称、叶缘卷曲、花叶、黄叶等致变现象,各种畸型叶出现频率与辐照剂量大小有关;M1根尖细胞中有多种染色体畸变类型,以染色体桥和断片频率较高,辐照剂量在 40 0Gy以上时根尖细胞异常率达 1 0 %以上;植株花粉育性与辐照剂量呈极显著负相关,京农 2号植株花粉育性达 5 0 %时的辐照剂量为 3 78Gy。

The regenerations adventitious bud was the better experimental materials compared with the callus of leaves.

不定芽的适宜诱变剂量为50~60Gy,由回归方程导出其致死剂量为122Gy,半致死剂量约为76Gy。

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