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Beta-thalassemia major is a serious hereditary hemolytic anemia which does great harm to human being.It is a monogenic disease characterised by a reduced synthesis of beta-globin chains,which dues to the Doint mutation or deletion of beta-globin gene and its control region.It not only decreases the hemoglobin level,but breaks the balance of alpha/beta synthesis ratio.The major cellular pathogenetic mechanisms in beta thalassemia are based primarily on the deleterious effects produced by the accumulation of the excess alpha globin chain.These excess alpha-globin chains cannot form stable tetrameric structure and deposit in erythroid cells.They cause large ineffective erythropoiesis on their own,accelerate red cells destruction,and lead to hemolysis.

地中海贫血是一种对人类健康危害严重的遗传性溶血性贫血病,是因β-珠蛋白基因及其调控序列的点突变或缺失致使β-珠蛋白肽链合成减少或完全停止,这不仅使患者血红蛋白水平降低,而且使原来在数量上与之持平的α-珠蛋白肽链相对过剩,这些相对过剩的游离α-珠蛋白肽链并不能形成稳定的四聚体,它们沉积在红细胞中导致了大量无效红细胞生成和红细胞寿命缩短,引起了严重的溶血性贫血。

It was she who bothered me and wasted my time and so tormented me that at last I killed her.

正是她在扰乱我,浪费我的时间,如此的折磨致使我最后杀死了她。

Having carefully studied all that this great thinker has had to say of the primitive state, I feel that I must postpone the consideration of his views till after the completion of fresh investigations, the chief of which, relating to Totemism, I have already referred to.

由于印刷错误或笔误,这是毫无疑问的,致使约翰·拉伯克爵士在他的《文明的起源》第三版(第252页脚注)提到前述文章时用了&自上一版,&也就是那本书的第二版。

Article 158 If before the commencement of the towage service, due to force majeure or other causes not attributable to the fault of either party, the towage contract could not be performed, either party may cancel the contract and neither shall be liable to the other.

第一百五十八条起拖前,因不可抗力或者其他不能归责于双方的原因致使合同不能履行的,双方均可以解除合同,并互相不负赔偿责任。

Article 159 If after the commencement of the towage service, due to force majeure or other causes not attributable to the fault of either party, the towage contract could not be performed, either party may cancel the towage contract and neither shall be liable to the other.

第一百五十九条起拖后,因不可抗力或者其他不能归责于双方的原因致使合同不能继续履行的,双方均可以解除合同,并互相不负赔偿责任。

Therefore, if it is abnormal in ammonia distilling section, the production of vitiol ammonia will be unqualified and the biochemistry section will be abnormal too.which will leads the transnormal of sewage let.

因此,蒸氨工序生产不正常,不仅硫氨工序的产品有可能不合格,而且会直接导致生化工序的不正常,致使焦化厂总排超标。

Its cause of formation, it is truncal of as concatenate as root system place because of,be defeated by conduit twist together, cause sap flow slow down, cause nutrition of cambium of the place cell to had been accumulated fill, and expand ceaselessly again make Bao Bi organizes twist to be out of shape be caused by.

其成因,是树干与根系连结地方的输导管因扭结,造成树液流动减缓,致使该处细胞形成层营养积累过盛,而且又不断扩展使薄壁组织扭曲变形所致。

In recent years, typhonic torrential rain disasters have occurred frequently and regional mountain tribes have been unable to know the local safety situation because roads, communication lines, and electric power have broken down.

近年来,台风豪雨灾害频传,山地部落易因道路、通讯及电力受损,而造成对外联繋中断,致使无法得知当地民众之安全情形。

Uberty in boys and girls and continue to fluctuate during a woman's menstrual cycle-cause the sebaceous glands to produce more sebum.

虽然科学家们已经指出了粉刺罪魁祸首--男性霍尔蒙激素,其在男孩和女孩的青春期开始增加,在女性月经周期时产生波动,这就致使皮脂腺产生更多的皮脂。

As to the part related to citizen participation, although regulation clause has norm proclaimed in writing, because the factor including various facts or legal system, cause it to standardize density insufficiently and unably to reach its legislative intention.

环境影响评估法,则系就环评程序所为之相关规定,其中对於民众参与,法规条文虽有明文规范,惟碍於前述诸多事实面或法制面因素,致使其规范密度不足而无法达到其立法意旨。

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Do you know, i need you to come back

你知道吗,我需要你回来

Yang yinshu、Wang xiangsheng、Li decang,The first discovery of haemaphysalis conicinna.

1〕 杨银书,王祥生,李德昌。安徽省首次发现嗜群血蜱。

Chapter Three: Type classification of DE structure in Sino-Tibetan languages.

第三章汉藏语&的&字结构的类型划分。