致使

Several anti-tumor cell lines and carbonic anhydrase Ⅱ model were established. More than 10000 compounds and extracts from plants were screened using these models and about 10 compounds showed strong inhibitory activities. Two species of plants Inula helianthus-aquatica and Saussurea deltoidea were chosen to investigate chemical and bioactivity constituents based on the results of screening of extracts and fractions. 58 compounds were isolated and identified from these two plants, 6 compounds were found to be new and 14 compounds showed anti-tumor activities. We also studied the anti-tumor mechanism of the compound bigelovin isolated from Inula helianthus-aquatica. Bigelovin was found with apoptotic activity against cell line U266 by lowering the amount of important transcription factor E2F-1 which inhibits the cell cycle at G0/G1 stage. Docking study on 7 natural new phenolic inhibitors of CA Ⅱ and 3D-QSAR study on 61 sulfonamide inhibitors of CA Ⅱwere also investigated. The calculated results were in good correlation with experimental results.

基于以上两种重要疾病和研究组方向，本论文工作开展了多个肿瘤细胞株和碳酸酐酶Ⅱ靶标模型的建立和筛选工作，累计筛选1万多个/次样品，发现10余个活性较强化合物；从粗提取物筛选结果中选取两种抗肿瘤活性强的菊科植物水朝阳旋覆花(Inula helianthus-aquatica)和三角叶凤毛菊进行了系统化学和活性成分研究，分离鉴定了58个化合物，发现6个新化合物和14个抗肿瘤活性化合物；通过合作对水朝阳旋覆花中活性较强的bigelovin进行了抗肿瘤作用机制研究，发现它可能是通过降低G2期重要的转录因子E2F-1，致使细胞周期阻滞在G0/G1期，引起多发性骨髓瘤U266细胞凋亡；开展了7个新的天然酚类CAⅡ抑制剂的对接研究和61个合成的系列磺酰胺类CAⅡ抑制剂的3D-QSAR分析，结果表明计算与实验一致。

Secondly, for the problem of irrationality of organizing organ, irrelevancy of distributing duty and disharmony of working flow, the paper puts forward better scheme and replying measurement.

最后，应用挣值法详细分析了梅坎铁路成本-进度的综合执行情况，找出了&当年大幅盈利，决算利润率剧降&的症结：由于进度、成本计划都是单独执行，没有进行综合分析和控制，造成判断失误，致使进度-成本控制失衡。

Two men drove a lorry and hit officers who were jogging on Monday in Kashi, leaving 16 dead and 16 injured.

周日在喀什市两个男的驾驶一辆卡车撞击正在出操的官兵，致使16人死亡16人受伤。

Carbon storages of the upper horizon in lessive dark brown forest soil, brown coniferous forest soil and mountain tundra soil were 10959 gC m-2 (0-20 cm), 4199 gC irf2 (0-10 cm) and 6171 gC m~2 (0-32 cm) respectively, occupy 60%,50% and 77% of total carbon storage. This showed that the upper horizon was accumulating soil organic carbon.

显然，低海拔地带土壤发育程度比高海拔带土壤发育程度要好，这是由于高海拔带土壤受火山喷发、气候、温度等自然因素的影响较大，从而致使土壤有机质的发育过程缓慢。

On the one hand, volume increases for office space in Pudong, on the other hand, the global economic downturn has also led to the relocation of many businesses plan to suspend or reduce the lettable area, resulting in declining rents.

一方面，浦东写字楼放量增大，另一方面，全球经济的低迷也致使许多企业暂缓搬迁计划或减少租用面积，从而导致租金下降。

In the machinelike world of classical physics, the human intellect appears since the mechanical nature of classical physics does not creative reasoning, the very ability that had made the formulation of classical principles possible.

在经典物理学那种像机器一样的世界中，人类的理性就显得，因为经典物理学的机械性质并不创造性的逻辑推理。而正是这种能力致使经典原理的阐述得以成为可能。

This book sparked riots around the world for what some called a blasphemous21 treatment of the Islamic faith (throughout the book, the Prophet Muhammad is referred to as Mahound, the medieval name for the devil). In 1989, five people died in riots in Pakistan and a stone-throwing mob injured 60 people in India.

这本书引发了全世界的无数暴动，因为一些人认为它亵渎了伊斯兰教(在整本书中，先知穆罕默德被称为魔罕德——中世纪时魔鬼的代称)。1989年，巴基斯坦发生暴动，五人死亡；在印度，一伙暴徒扔掷石块，致使60人受伤。

This book sparked riots around the world for what some called a blasphemous treatment of the Islamic faith throughout the book, the Prophet Muhammad is referred to as Mahound, the medi name for the devil. In 1989, five people died in riots in Pakistan and a stone-throwing mob injured 60 people in India.

这本书引发了全世界的无数暴动，因为一些人认为它亵渎了伊斯兰教(在整本书中，先知穆罕默德被称为魔罕德，而后者是中世纪时魔鬼的代称)。1989年，巴基斯坦发生暴动，五人死亡；在印度，一伙暴徒扔掷石块，致使60人受伤。

According to these five characteristics, the article analyzes the "dazzle" phenomena in which writers are illiberal to desire describing, discloses that it is confused to express the theme in "dazzle" form and readers will fall into a mazed condition in reading. How the current literature break out the "dazzle" morass is also discussed in the paper to achieve the heart clear and man not dropping into the desire river.

且根据这五个特征对当今文学偏执于欲望叙述的这种&眩惑&创作现象进行了归纳、追溯、剖析和思考，揭示了采用&眩惑&形式表达欲望主题的盲见及创作、阅读的困境，探讨如何使当今文学走出&眩惑&之阵，既回归到人的生命场域，让心灵在欲望中自行敞亮，又不致使人坠入欲望之河随波逐流使之泛滥成灾。

" Bonded, is one such State, that is, two different objects, through close contact, in combination, you can pass the transimitting mechanicochemical or work ".

&粘合，是这样一种状态，即两个不同的物体，通过紧密的界面接触，结合在一起，致使可以通过界面传递机械力或功&。

Do you know, i need you to come back

你知道吗，我需要你回来

Yang yinshu、Wang xiangsheng、Li decang,The first discovery of haemaphysalis conicinna.

1〕 杨银书，王祥生，李德昌。安徽省首次发现嗜群血蜱。