自身免疫作用

OBJECTIVE: To separate the available composition that inhibits immunity form Ephedra sinica Stapf , and to study its effects on experimental autoimmune thyroiditis and its mechanism.

目的：从麻黄中分离出具有免疫抑制作用的有效部位，并研究其对小鼠实验性自身免疫性甲状腺炎的治疗作用及机理。

The improvement of patient immunopotency may be related not only to Chinese medicine but also to redintegration ability of patient.

结论SARS患者免疫功能的升高可能与中医药干预作用有关，但亦不能排除为患者自身机体恢复的过程。

The results of this study indicated that there were changes on the distribution of T-lymphocyte subsets in patients with asthenia gravis.

MG患者存在有明显的T细胞亚群的改变，符合自身免疫性疾病的特点：胸腺切除手术近期对患者周围血中各淋巴亚群无明显影响；胸腺切除围手术期使用TP-5治疗对其发挥免疫调节作用的主要机理之一。

2The distribution of HIF-1 a and COX-2 was unequal;.(3)These findings indicate that HIF-1a and COX-2 may be two important factors in pulpal lesions and there is a significantly hypoxia condiction in inflamed pulp .(4)The increase of HIF-1 a is a possible mechanism for hypoxia preconditioning .(5)Our results suggested that pulpal fibroblasts as well as macrophages might be involved in the pathogenesis of irreversible pulpitis.

和COX一2的表达均有不同程度的变化，在牙髓炎病程中可能发挥着重要的生理和病理作用，③在牙髓炎进程中和牙髓自身修复过程中存在着缺氧环境和缺氧耐受机制，④牙髓成纤维细胞有可能与单核巨噬细胞一同参与牙髓炎的病理进程，且具有修复和免疫功能。

Glucocorticoid is a kind of steroid compound synthesized and secreted by adrenal cortex fascicular zone, which is a key factor of the hypothalamus-hypophysis-adrenal gland-immune axis.

糖皮质激素(glucocorticoid，GC)是下丘脑-垂体-肾上腺轴的关键分子，除具有重要的生理作用外，还具有很强的免疫抑制作用，临床上被广泛用于自身免疫性疾病的治疗。

To inquire into association between susceptibility to AIDP, AMAN and frequencies of HLA alleles and possible differencies in distribution of HLA alleles betwen AIDP and AMAN by genomic typing for HLA-class Ⅰ, class Ⅱ alleles, and to try to found out the effects of self intrinsic fators of GBS patients on occurence of two subtype from immunogenetic angle.

通过对AIDP和AMAN两种GBS亚型的HLA-Ⅰ类和Ⅱ类等位基因的分型，探讨两种亚型的易感性与HLA等位基因分型的关系以及两种亚型在HLA等位基因分布上可能存在的差异，从免疫遗传学角度寻找自身内在因素在GBS不同亚型发病中的可能作用。

These results indiacated that tranferring macrophages combinedwith cytokines could be a new adoptive immunotherapy protocol foradvanced cancer,and rTNF used in vivo locally could induce andactivate macrophages to kill tumor cells.Monocytes when activatedunderwent a series of phenotypic and functional changes includingthe expression of IL-2R which may provide an important immunoregu-latory pathway.The presence of lectin-like molecules on thesurface of monocytes and tumor cells may bring theeffector/target cells together,thus facilitating the inductionof apoptosis in target cells by triggering the production ofcytolytic factors and the modification of target of targer cell surface anti-gens.(such as HLA-DR).

综合以上结果可以得出以下结论：转输巨噬细胞并结合细胞因子的联合应用是肿瘤继承性免疫中的又一新的、有潜力的方法；抗肿瘤细胞因子rTNF可通过激活巨噬细胞在体内抑制对其不敏感的肿瘤细胞的生长；人单核细胞在一定条件下激活后，可表达IL-2R，进而一方面增强其自身对IL-2的敏感性，另一方面在体内也具有调节T细胞功能的作用；单核细胞和肿瘤细胞上存在的凝集素类受体可促使两种细胞之间在凝集素介导下相互接近，并诱发单核细胞产生细胞毒因子，以及通过调节靶细胞上表面抗原的表达，促进诱导靶细胞的细胞凋亡。

Department of Haemotology,Zhongda Hospital,Southeast University,Nanjing210009,China）Abstract:Cytokine induced killeris a new kind of immune cells which have non MHC restric-tion,highly proliferation and cytotoxicity.Their activities are superior to lymphokine activated killer cells.Immunotherapy of CIK cells can significantly improve clinical symptoms,but hardly have any side effects.

摘要］ 细胞因子诱导的杀伤细胞（cytokine induced killer，CIK）是一种非MHC限制性的新型免疫活性细胞，其增殖能力强、杀瘤活性高、副作用小，优于淋巴因子激活的杀伤细胞，对于提高患者自身抗肿瘤免疫能力有重要作用。

As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸，那乌黑、忧郁的眼睛，她便会相信，他一定作过不幸的爱情的受害者。

Maybe they'll disappear into a pothole.

也许他们将在壶穴里消失