自身免疫作用

Objective To investigate the role of proteoglycan autoimmunity in the pathogenesis of rheumatoid arthritis.

目的探讨针对蛋白聚糖的自身免疫反应在类风湿关节炎发病中的作用。

CD4+ 25+ regulatory T cells play a role in controlling the development and progression of autoimmunity.

CD4+ 25+调节性T细胞在控制自身免疫的发展和进展起重要作用。

Objective To investigate the importance of autoimmunity against β1-adrenoreceptor in the pathogenesis of dilated cardiomyopathy.

目的研究β1肾上腺素能受体的自身免疫在扩张性心肌病发病中的重要作用。

Cellular immunity plays an important role in defense against diseases, such as pathogenic infection,autoimmunity and tumor.

摘要细胞免疫在防御外来病原感染、自身免疫及肿瘤等疾病中发挥重要作用。

NAAs are the most important part of natural immunity, which maintains the homeostasis of human body , prevents autoimmunity diseases, has anti-inflammation and anti-tumor surveillance function.

NAA是构成天然免疫的重要组成部分，可以维持自身稳定、防止自身免疫病发生，具有抗炎、抗肿瘤监视作用等。

Recent elucidation of the role of central tolerance in preventing organ-specific autoimmunity has changed our concepts of self/nonself discrimination.

最近关于中枢免疫耐受在防止特异性器官自身免疫的作用的阐述改变了我们以往识别"自我"、"非我"的概念。

Autoimmunity hypothesis of schizophrenia figures schizophrene has a certain degree of immunological functional disturbance,Hypothalmu- pituitary- adrenal axis can produceimmunosuppression. Hydrocortisone,the production of HPA axis,serve as important medium of immunosuppression, so we presume that hydrocortisone possibly induce immunological dysfunction of schizophrene.

精神分裂症的自身免疫假说认为精神分裂症患者存在一定程度的免疫功能低下，而下丘脑-垂体-肾上腺轴功能紊乱被认为是引起免疫抑制作用的主要机制之一，其中皮质醇是免疫抑制作用的重要介质，因此我们推测精神分裂症患者可能存在有皮质醇含量增高有关。

This subset is hyporesponsive and anergic to antigen stimulation. Recently, it has been demonstrated to participate in the immune deficiency in human immunodeficiency virus infection and has close relationship with the development of acquired immunodeficiency syndrome. Meanwhile, the CD4(superscript +)D25(superscript +)Treg is also infected when the human body is invaded by HIV. The CD4(superscript +)CD25(superscript +)Treg will finally be killed by the mechanism of antibody-dependent cell-mediated cytotoxicity. Because of the decrease of the CD4(superscript +)CD25(superscript +)Treg, it can't function as a immune suppressor as a result of the excess of activation of HIV and gradually exhausting of the T cell, which shows that the CD4(superscript +)CD25(superscript +)Treg plays a inhibitory role in the different stages of the development of the HIV as well as different effects in the pathogenesis of AIDS.

它能够抑制自身免疫病的发生和发展，参与肿瘤免疫的调节，同时在感染和移植免疫中也发挥着极其重要的作用。T细胞的这一亚群具有免疫调节和免疫抑制的特性，新近发现它亦与爱滋病的发生、发展关系密切HIV进入人体后，CD4D25调节性T细胞抑制了机体的免疫效应但它也同时被感染，最终由于细胞毒的作用而死亡由于调节性T细胞数量的减少不能有效的发挥其抑制作用，HIV持续的过度活化使得T细胞逐渐耗竭说明在HIV发生、发展的不同阶段Treg细胞可能都发挥了免疫抑制作用，但是却对HIV感染与爱滋病发病的进程产生了不同的效应。

In recent years,studies have revealed important roles of BAFF and its receptors in immune regulation of antibody isotype switching,germinal center maintenance,and T cell co-stimulation,that may provide new drugs in the future for the treatment of autoimmune disorders,lymphoma and B cell immunodeficiencies.

近几年来的研究表明，BAFF及其受体在抗体类型转换、生发中心维持、T细胞共刺激等方面发挥着重要的免疫调节作用，对自身免疫疾病、淋巴瘤和B细胞免疫缺陷的治疗具有潜在的应用前景。

The endolymphatic sac contains immunocompetent cells capable of processing and presenting viral or bacterial antigen, potentiating the immune response, attacking the invaders directly or attacking infected cells, and developing immunoglobulin responses in situ.

本研究拟探讨DC是否参与了内耳的免疫反应，在内耳的这种反应中神经免疫和自身免疫与细胞免疫之间有相互影响，这种影响对内耳的形态和功能是否有保护作用。

As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸，那乌黑、忧郁的眼睛，她便会相信，他一定作过不幸的爱情的受害者。

Maybe they'll disappear into a pothole.

也许他们将在壶穴里消失