自身免疫

Introduction: Self tolerance is regarded as the anergy condition for the immune system to self antigens.

前言 自身免疫耐受是指机体免疫系统对自身抗原的无应答状态。

The journal publishes reports on clinical and experimental research in autoimmunity, as well as basic research, molecular, cellular and whole organism levels, in areas such as immunogenetics, immune cell signaling, molecular markers of autoimmune diseases, immune interventions, new animal models, transplantation, stem cell therapy, and gene therapy.

杂志刊载自身免疫的临床和实验性研究报告，以及基础研究，分子，细胞和整个有机体水平的研究，涉及领域包括免疫遗传学，免疫细胞信号，自身免疫性疾病的分子标记，免疫干涉，新动物模型，移植，干细胞治疗，和基因治疗。

Microbial infections of eye such as microbial keratitis, ocular onchocerciasis, bacterial endophthalmitis, viral retinitis and infectious uveitis are unfortunately common.

Toll样受体是自身免疫的关键受体，它参与宿主对致病微生物的识别和防御等感染免疫过程，也与人体的获得性免疫密切相关，是目前免疫学研究的重点和热点。

Autoimmunity hypothesis of schizophrenia figures schizophrene has a certain degree of immunological functional disturbance,Hypothalmu- pituitary- adrenal axis can produceimmunosuppression. Hydrocortisone,the production of HPA axis,serve as important medium of immunosuppression, so we presume that hydrocortisone possibly induce immunological dysfunction of schizophrene.

精神分裂症的自身免疫假说认为精神分裂症患者存在一定程度的免疫功能低下，而下丘脑-垂体-肾上腺轴功能紊乱被认为是引起免疫抑制作用的主要机制之一，其中皮质醇是免疫抑制作用的重要介质，因此我们推测精神分裂症患者可能存在有皮质醇含量增高有关。

This subset is hyporesponsive and anergic to antigen stimulation. Recently, it has been demonstrated to participate in the immune deficiency in human immunodeficiency virus infection and has close relationship with the development of acquired immunodeficiency syndrome. Meanwhile, the CD4(superscript +)D25(superscript +)Treg is also infected when the human body is invaded by HIV. The CD4(superscript +)CD25(superscript +)Treg will finally be killed by the mechanism of antibody-dependent cell-mediated cytotoxicity. Because of the decrease of the CD4(superscript +)CD25(superscript +)Treg, it can't function as a immune suppressor as a result of the excess of activation of HIV and gradually exhausting of the T cell, which shows that the CD4(superscript +)CD25(superscript +)Treg plays a inhibitory role in the different stages of the development of the HIV as well as different effects in the pathogenesis of AIDS.

它能够抑制自身免疫病的发生和发展，参与肿瘤免疫的调节，同时在感染和移植免疫中也发挥着极其重要的作用。T细胞的这一亚群具有免疫调节和免疫抑制的特性，新近发现它亦与爱滋病的发生、发展关系密切HIV进入人体后，CD4D25调节性T细胞抑制了机体的免疫效应但它也同时被感染，最终由于细胞毒的作用而死亡由于调节性T细胞数量的减少不能有效的发挥其抑制作用，HIV持续的过度活化使得T细胞逐渐耗竭说明在HIV发生、发展的不同阶段Treg细胞可能都发挥了免疫抑制作用，但是却对HIV感染与爱滋病发病的进程产生了不同的效应。

Type 1 diabetes mellitus and the autoimmune thyroid disease are the most common components of autoimmune polyglandular syndrome . Latent autoimmune diabetes in adults is a subtype of type 1 diabetes mellitus .

1型糖尿病(T1DM)和自身免疫性甲状腺病是自身免疫多腺体综合征的2个重要组成部分，两病合并属于自身免疫多腺体综合征Ⅱ型。

Prof. Yangtao:On the issue of antigen specific prevention therapy for type I diabetes, which in your opinion is more involved, the auto-antibody or auto-reactive cells?

杨涛教授：您提到1型糖尿病抗原特异性的预防措施，您认为是自身免疫抗体重要还是自身免疫细胞重要？

Autoimmune Diseases - DMG modulates the immune response in those with autoimmune diseases.

自身免疫的疾病– DMG操控自身免疫系统的反应来调节自身免疫的疾病。

The endolymphatic sac contains immunocompetent cells capable of processing and presenting viral or bacterial antigen, potentiating the immune response, attacking the invaders directly or attacking infected cells, and developing immunoglobulin responses in situ.

本研究拟探讨DC是否参与了内耳的免疫反应，在内耳的这种反应中神经免疫和自身免疫与细胞免疫之间有相互影响，这种影响对内耳的形态和功能是否有保护作用。

As the product of the tumor (including ectopic hormone produced) or abnormal immune response (including cross-immunity, autoimmune and immune complex deposition, etc.) caused by endocrine, nerve, blood, digestion, bone joints, kidneys, skin lesions and other systems, causing corresponding clinical symptoms, known as paraneoplastic syndrome.

由于肿瘤的产物或异常免疫反应（包括交叉免疫、自身免疫和免疫复合物沉积等）引起内分泌、神经、造血、消化、骨关节、肾脏、皮肤等系统发生病变，引起相应的临床症状，称为副肿瘤综合征。

As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸，那乌黑、忧郁的眼睛，她便会相信，他一定作过不幸的爱情的受害者。

Maybe they'll disappear into a pothole.

也许他们将在壶穴里消失