膜骨

Comparison the in vivo activity of 90％EtOH fraction and compound 21 with estradiol, indicated the 90％EtOH fraction behaved the stronger activity on total mineral content, total density, trabecular mineral content, trabecular density and the anti-twist strength of the proximal tibia in OVX rat than estradiol, but compound 21 displayed the weaker activity on total mineral content, total mineral density, trabecular mineral density, cortical mineral content, cortical mineral density, cortical thickness and the anti-twist strength of the proximal tibia than estradiol.

通过90％乙醇部位及化合物21都与阳性对照药雌二醇的纵向比较后，在大鼠OVX模型中，90％乙醇部位高剂量组在提高全骨的骨矿含量和骨密度、松质骨的骨矿含量和骨密度及骨的抗扭力方面，作用强于阳性对照组雌激素类化合物，化合物21在小鼠OVX模型中，抑制了全骨的骨矿含量、骨密度和全骨断面面积的降低，松质骨骨密度的降低，皮质骨的外膜周长的增长，皮质骨骨矿含量量、皮质骨厚度和皮质骨密度的下降及抗扭力的减弱。

Normal synovial membrane, OA synovial membrane and normal cancellous bone were obtained as negative or positive control.

结果 界膜组织中PDGF-Bm RNA的表达量由高到低依次为OA滑膜、溶骨区界膜、正常松质骨、非溶骨区界膜、正常滑膜(P＜0.01)。

The palate bone defects can be repaired completely by GBR with collagen composite of human recombinant morpho...

1复合Hr -BMP胶原膜GBR具有确实有效的骨引导和骨诱导性，在骨缺损修复的早期阶段即可产生大量的新骨；2 复合Hr-BMP胶原膜植入后 4周内的成骨活动最活跃，胶原膜和复合Hr-BMP胶原膜在其降解吸收过程中，不干扰后续的成骨活动；3仍有必要构建具有适合的吸收降解性和一定力学强度的隔膜材料。

MRI: IOM was ruptured in a range 3～8 cm proximal to the tibial plafond in the 8 cases. No IOM rupture was found at the high fibular fracture level.

2MRI检查结果：骨间膜损伤水平均在胫距关节面上3 cm～8 cm，其近端骨间膜保持完整，高位腓骨骨折处骨间膜亦无损伤。

Then the cultivated chondrocytes were embedded in fibrin glue fused on spongy bone, covered with priosteal flap; the complex was used to repair the femoral trochlea osteochondral defect which size is 3mm × 4mm × 4mm made in rabbit knee joint.

在A组的每只兔子的一侧膝关节股骨滑车部人为造成3mm×4mm的骨软骨缺损，骨刀切除软骨下骨到髓腔渗血为止(厚约4mm)，压迫后FG止血；取髂骨骨块，并尽可能保留松质骨，取下的骨块用PBS反复清洗，以除去血细胞，将松质骨填充在骨缺损处，松质骨面朝向关节腔，高度与周边软骨下骨齐平，把骨膜片生发层朝向关节腔，用无创伤缝合线缝合在周边的软骨或滑膜组织上；向EP管中加入1/2悬液体积的FG主体胶溶液并混匀，再与主体胶等体积的催化剂溶液一同注射入骨膜与骨块密闭的腔隙中；同理处理另一侧膝关节。B组处理与A组相比只是不加入软骨细胞；C组造成骨软骨缺损，FG覆盖创面后单纯用骨膜修复缺损。

At the contralateral side, an ischiac bone graft (baseline 3 4 0.87) was transplanted. The healing period was 5 months. Group A11: The animals were treated in the same manner as in Group A5 with the difference that the healing period was 11 months. Group B5: The animals were treated in the same manner as in Group A5 with the difference that an e-PTFE membrane was adapted oer the bone graft on each side of the jaw.

愈合时间为5个月。A11组：用与A5组相同的方法处理小鼠，愈合时间为11个月。B5组：处理小鼠的方法与A5组相同，在每侧颌骨的骨移植物上方各置一片e-PTFE膜。B11组：实验方法与B5组相同，但在骨移植5月后，进行第二次手术取出生物膜，愈合时间为11个月。z在下颌骨骨量增加后，分别于第5个月处死A5组及B5组的小鼠，第11月处死A11组及B11组的小鼠，取下颌骨标本，体式显微镜测量骨移植物的宽度、长度及高度。

Results Extensive and diffuse synovial hyperplasia can be seen in patients with RA;synovial pannus formation can be seen in 25 cases.

结果RA组病人均可见广泛、弥漫的滑膜增生，其中25例病人可见滑膜血管翳形成，而OA组仅7例病人可见轻度滑膜增厚，未见滑膜血管翳形成者(X2=55.78P.005)；RA组关节软骨及软骨下骨改变较严重且弥漫，而OA组软骨退变则较局限，且以关节摩擦大的部位受损为著，其软骨下骨改变较为局限，常常见于IV软骨退变；关节腔积液、半月板及韧带改变，在OA组与RA组之间无差异。

TyPe II collagen induced arthritisln the rat ank1e joint andoVathumin as antigen induced arthritis WA in the rabbit knee joint wereestab1ish2 Qualitative evaluation of me in skin, muscle, synovium, cedilagearound joint and blood was performed by OMA3 The CIA rats were treated on day 7 after hind paw swelling and erythemaAnimals were injected intravenously with ase at a dose of 10mg/kg,tWenty minuots 1ater, one ankle of the rats random1y assigned was exPosedlaser irradiation at l00J/cm fOr l000 seconds, and another ankle wasM grouP wihout laser The other two groups is unmanipulatedcontrol group and untreated CIA group Bimaleolar ankle widthmeasuremellts were taken in all animals every tWo days using amicrometer The histopathology of the ank1e Joint was assessed at day 21after disease onset4 The pro1iferating cell nuclear antigen WCNA of CIA treated by PDT andthe HMME group without laser was doterdrined by immunohistochemiStry5 The AfA rabbits were treated on day 7 after knee swelling and erythemaThe theraPy invo1ved lntravenous injection of l0mg/kg HMME, fOl1owedby 20 minues period in dim light, and transdermal light treatment with\l00 J/cm2 fOr l000 seconds The inner sides of the treated Anees wereirradiated at first, and then the outer side did 24 hours later, the synovialtissue of the Anees joint were removed and in situ cel1 aPoptosis wasdetCCted With tednal deoxync1eotidyl transferase-mediated dUTP nickend labelingR6suIt8:l The pathologic changes of CIA and AIA include subsynovial inflammation,opovial hyPerplasia, pannus formation, cartilage and bone destructionresemble RA.2 The studies demonstrated that there are different uptake of HMME withinskin, muscle, synovium, cartilage and b1ood, and the synovium cou1draPidly uPtake more ase than skin and cartilage at the firSt 30 minuesaller intravenous injection of HMME3 The bimaleolar anke width had no different among PDT treated group,H group withollt 1aser and untreated CIA group But hlstologicalevaluation showed statiStical1y significallt reductions in synovialhyperplasia, pannus formation and cart1lage reosion, bone destruction andtotal score in PDT treated group4 Image analysis showed that the ratlo bforeen the areas of the coufltedobect to that of the entire area in PDTtreated grOup is lower than that in conirol group, but the integrated oPticaldensity had no different between the two groups5 Imape analysis showed that the ratio between the area of the countedobject to that of the e

治疗组在大鼠出现踝关节红肿后1周，炎症达到高峰时进行PDT治疗。随机治疗大鼠一侧的踝关节，另。2。一一侧作单纯HMME 对照。治疗方法是大鼠麻醉后尾静脉注入 HMME10ngkg，20分钟后踝关节照光，激光波长627.sum，功率密度 100mwcm'，照射时间1000秒，能量密度100）／。治疗后避光喂养72 小时。隔日一次测量大鼠的踝关节左右横径，治疗后两周取关节进行病理d 观察。 4。大鼠CIA模型用上述方法进行PDT治疗后，治疗组和单纯HMME 组用兔疫组化SP法检测石蜡切片的核增殖抗原。 5。兔AIA模型在关节炎出现第七天进行PDT治疗，随机治疗一侧膝关节，另一侧作自身对照。兔耳静脉注入I'arrainrelomg／Kg，20分钟后，膝关节用金蒸气激光照射，激光能量密度100）儿旷。24 ／J'时后取膝关节滑膜作病理检查，并用脱氧核昔酸末端转移酶介导的缺口末端标记法原位检测凋亡细胞。结果： 1。模型观察：CIA大鼠炎症高峰期滑膜下炎细胞浸润明显，滑膜细胞明显增殖，炎症达到高峰后二周，血管缀形成，并侵蚀和破坏软骨和骨， CIA模型病理改变与人类RA相似。兔AIA模型膝关节滑膜病理可见滑膜细胞增生，滑膜下炎细胞浸润，也与人类RA滑膜改变相似。 2。关节周围组织中光敏剂含量的测定结果表明，各组织对HMME 的吸收速度和吸收量不同，荧光值一时间曲线不同，滑膜组织比皮肤和软骨对 HMME的吸收多，在 2 0分钟时即有明显差异。 3.PDT对CIA模型的治疗结果表明：PDT治疗后关节炎组、单纯 HMME组和治疗组踝关节左右横径统计学检验差异没有显著性，但病理评分PDT治疗组滑膜增生、血管资形成及软骨破坏、骨破坏和总分比关节炎对照组和HMME对照组好，统计学检验差异有显著性。。3＿军医进修学院硕士学位论文中文摘要 4.PDT治疗组PCNA阳性细胞较对照组少，图像分析结果表明面密度（阳性染色的面积总和与统计视野面积的比值）治疗组小于对照组，统计学检验差异有显著性。。 5.PDT治疗组凋亡阳性细胞较对照组明显增多，图像分析结果单位视野内阳性细胞数和面密度PDT治疗组高于对照组，统计学检验差异有显著性。凋亡细胞核直径PDT治疗组较小，与对照组相比，统计学检验差异有显著性。结论：二。CIA、AIA的病理改变类似人类RA，可作为研究RA病因、发病机制、检查及治疗方法的模型。 2。各组织对HMME的吸收速度和吸收量不同，滑膜组织比皮。

Method］thirty patients who had definite chronic lumboscaral compartment syndrome without other lumbal diseases were choosed respectively to test muscle force of lumbar and abdomen,intra-sacrospinal muscle pressure,blood routine,esr,ck,ck-mm,ldh and ldhs.all patients received decompressive operation.skeletal muscle specimens taken from sacrospinal muscle in each operation were possessed for histological and ultrastructuml observation.

［目的］探讨慢性骨筋膜间隔综合征所致下腰痛的发病机理。［方法］选取明确诊断为腰骶部慢性骨筋膜间隔综合征且未合并其他腰部疾病的患者30例，分别行腰腹肌肌力测定，竖脊肌内压测定，血常规，血沉，肌酸激酶及同工酶，乳酸脱氢酶及同工酶（ldh5）测定，采用骨筋膜间隔切开减压手术治疗。

The mean post- operative air conduction and bone conduction PTA were 36.59 dB and 24.23 dB, respectively.

对47例（47耳）胆脂瘤中耳炎病人，在清除病变的同时一期行鼓室成形术，用耳后带蒂肌筋膜骨瓣修复听骨链进行听力重建。

Breath, muscle contraction of the buttocks; arch body, as far as possible to hold his head, right leg straight towards the ceiling (peg-leg knee in order to avoid muscle tension).

呼气，收缩臀部肌肉；拱起身体，尽量抬起头来，右腿伸直朝向天花板（膝微屈，以避免肌肉紧张）。

The cost of moving grain food products was unchanged from May, but year over year are up 8%.

粮食产品的运输费用与5月份相比没有变化，但却比去年同期高8％。