腺苷

Adenosine, a metabolite of adenine nucleotides, is one of the major neuromodulators.

腺苷是腺嘌呤核苷酸的代谢产物，是一种重要的神经调质。

According to the complex structure of AdSS and its substrate IMP as well as the optimized stable conformation of natural inhibitors, the interaction mode between AdSS and its inhibitors was studied with molecular docking, mechanical optimization and molecular dynamics simulation methods. These results show that the phosphate group and the hydantoin ring of the inhibitors form the pharmacophore model.

基于腺苷酸琥珀酸合成酶与其底物肌苷单磷酸复合物的晶体结构以及获得的天然抑制剂衍生物稳定构象，利用分子对接、分子力学优化及常温分子动力学模拟对AdSS酶与天然抑制剂及其衍生物的相互作用复合物结构进行理论预测。

The compound ononim adenosine pinitol were first found in this plant.

其中，芒柄花苷、腺苷、肌醇甲甙首次从黄芪属植物中分离得到。

Wenxin capsule can promote endolethial cells releasing CO and synthesing 〓, enhance activity of HO, induce angiectasis through activating guanylic cyclase and adenglate cyclate of intracellar of vessel smooth muscle cell to enhance content of intracellar cGMP and AMP. 3. Wenxin capsule can inhibit releasing of platelet activiting factor 〓 which inhibit platelet aggregation and have antithrombosis function. 4. Wenxin capsule can promote activity of t-PA, reduce activity of PAI-1, strengthen fibrinolytic function, therefore inhibit fibrin disposition. 5. Wenxin capsule can inhibit synthesis of smooth muscle cellular DNA. Its function don't kill it directly but prevent transformation from period Go to peried S. 6. Wenxin capsule is an effective prescription of anti-coronary atherosclerosis atherosis. The results of image pattern analysis tastifies that area of lipid plaque in treating group reduce 54% and 58% in contrast with that in control group. The results of light, electro- microscopy show that structure of endolethial cell and smooth muscle cell in treating group is more integral than that in control group.

其作用机制之一是由于该药具有良好的调脂降脂作用，其不仅能明显降低血清LDL-c及升高HDL-c含量，且能有效阻止TC沉积于血管壁，从而保护内皮细胞结构完整；此外，温心胶囊尚具有明显的抗氧化作用，该药不仅能明显降低血浆LPO含量，且能提高SOD活性，同时其对血红素在细胞内代谢的调节作用也参与了抗氧化过程。2 温心胶囊能明显促进内皮细胞释放CO及合成〓，提高HO活性，通过激活血管平滑肌细胞内鸟苷酸环化酶及腺苷酸环化酶引起细胞内cGMP、AMP浓度增加而引起血管舒张。3 温心胶囊能明显抑制血小板激活因子〓的释放，从而抑制血小板聚集，抗血栓形成。4 温心胶囊能明显提高t-PA活性，降低PAI-1活性，增强纤溶功能，从而抑制纤维蛋白沉积。5 温心胶囊能明显抑制平滑肌细胞DNA合成，其抑制作用不是直接杀伤抑制，而是阻止细胞由Go期向S期转化。6 温心胶囊是抗冠状动脉粥样硬化的有效制剂，图象分析结果证实，该药治疗组脂斑面积比对照组缩小了54％和58％，光电镜结果显示内皮细胞及平滑肌细胞结构较为完整。

The results show that before treatment with Chinese herb, the content of plasmatic cAMP is decreased, while cGMP is increased, cAMP/cGMP is decreased (P＜0.01) in group T.

对中药组60例患者，采用放免分析法测定中药治疗前后血浆环—磷腺苷cAMP、环—磷鸟苷cGMP含量，以40例健康女性的检测值做为对照组进行比较。

Beside the catalysis in transferring the high energy phosphate bond from ATP to NDP, NDPKs also show the activities of NDP kinase and proteinic phosphotransferase.

该酶除了催化腺苷三磷酸和核苷二磷酸之间高能磷酸基团的转移外，还具有NDP激酶活性和蛋白磷酸转移酶活性，并参与转录调控和信号转导。

Methods: Eleven B-CLL patients were studied. Leukemic lymphocytes with (n=8) or without (n=3) P2z receptors were exposed in vitro to ATP, benzoylbenzoic-ATP, 2-methylthio-ATP(2MeSATP), adenosine-5′-［γ-thio］ triphosphate, and other nucleosides for 8h. Apoptosis was detected by electron microscopy, agarose gel electrophoresis, and quantitative TdT assay. Results:Apoptosis was detected only in leukemic lymphocytes with P2z receptors. By using the quantitative assay, ATP-inducing DNA strand breaks were found to occur specifically for BzATP, ATP and 2MeSATP, but not for ATP-γS and other nucleosides.

将表达P2z受体［P2z］与不含P2z受体［P2z］的两组CLL细胞分别同1.0mmol/L三磷酸腺苷体外培养8小时，以电镜、DNA凝胶电泳和定量DNA 3′端TdT法检测细胞凋亡；并对ATP、苯甲酰苯甲酸ATP、2-甲基硫ATP(2MeSATP)、γ-硫代ATP及其它核苷的诱导效应和氧化型ATP、1-［N，O-二(5-异喹啉碘酰基)N-甲基-L-酪氨酰］-4-苯哌嗪KN-62）的抑制效应做定量研究。

Results The pD2 value (the affinity to M-receptors of agonist) of Erycibele alkaloid's miosis is 3.60±0.15 and its IOP lowering action is 3.49±0.07. In the isolated iris contracting experiment, its pD2 value is 6.38±0.12. M3 receptor antagonist is the strongest antagonist in inhibiting the miosis, IOP lowering action and isolated iris pupillary contracting action of Erycibele alkaloid. 0.01% Erycibele alkaloid can cause the decrease of cAMP and the increase of cGMP in the aqueous humor.

结果 测定丁公藤碱缩瞳作用的pD2值为3.60±0.15，降眼压作用的pD2值为3.49±0.07，离体虹膜收缩作用的pD2值为6.38±0.12.M1～M3受体拮抗剂均可拮抗丁公藤碱的缩瞳作用、降眼压作用及离体虹膜收缩作用，其中以M3受体拮抗剂的拮抗作用最强。0.01％丁公藤碱可使房水环磷酸腺苷(cyclic adenosine monophosphate，cAMP)含量降低，环磷酸鸟苷(cyclic guanosine 3，5-monophosphate；cGMP)含量升高。

The contents of uridine, adenosine and cordycepin were simultaneously determined by RP-HPLC method.

用硫酸-苯酚法测定北虫草中多糖含量；用RP-HPLC法同时测定北虫草中尿苷、腺苷和虫草素含量。

A simple,sensitive and reproducible high performance liquid chromatography-electrospray ionization mass spectrometry method for simultaneous separation and determination of adenosine and uridine is developed.

本文报道采用电喷雾离子化，用高效液相色谱质谱联用法同时分离和测定冬虫夏草及其代用品中主要活性成分尿苷和腺苷的方法。

I didn't watch TV last night, because it .

昨晚我没有看电视，因为电视机坏了。

Since this year, in a lot of villages of Beijing, TV of elevator liquid crystal was removed.

今年以来，在北京的很多小区里，电梯液晶电视被撤了下来。