腺癌

Objective: To study the treatment of experimental lung metastasis by intratracheal injection of IL-18 gene recombinant adenovirus.

目的：研究气管内应用白细胞介素18(IL-18)重组腺病毒(AdIL-18)对实验性肺转移癌的治疗作用。

In addition, SW480 and HCT116 cells were treated with deoxycholic acid for 15, 30, 45, 60, 90 and 120 minutes. It was found that the deoxycholic acid treated cells showed an elevation of ATP activity by 12.35 %, 20.08 %, 29.69 %, 33.56 %, 45.85 %, 54.32 %, respectively. While the HCT116 treated cells, showed an elevation of ATP activity by 3.69 %, 5.59 %, 8.52 %, 12.26 %, 16.52 %, 19.71%, respectively.From the experiments conducted using the cell lines described above, it was further confirmed that genes CYP7A1 (cytochrome P450, family 7, subfamily A, polypeptide 1), AKR1D1 (aldo-keto reductase family 1, member D1), ALDH1A1 (aldehyde dehydrogenase 1 family, member A1), BAAT (bile acid Coenzyme A: amino acid N-acyltransferase), ABCA1 (ATP-binding cassette, sub-family A, member 1), APOC3 (apolipoprotein C-III), LIPA, LIPE (lipase, hormone-sensitive), PTGER2 (prostaglandin E receptor 2) and PTGS2 (prostaglandin-endoperoxide synthase 2) were up-regulated.

此外，为了证实其脂肪代谢产物胆酸对细胞癌化的影响，亦使用SW480和HCT116细胞株，经由脱氧胆酸在15分钟、30分钟、45分钟、60分钟、90分钟和120分钟处理后，其细胞增生比率分别有12.35%，20.08%，29.69%，33.56%，45.85%和54.32%(p.05)以及3.69%，5.59%，8.52%，12.26%，16.52%和19.71%(p.05)上升情形，并从这些细胞株进一步证实CYP7A1(细胞色素P450-7A1)、AKR1D1(醇醛酮还原酶-1-D1)、ALDH1A1(醛脱氢酶-1-A1)、BAAT(胆酸辅酶A：氨基酸N-醯基转移酶)、ABCA1(三磷酸腺苷结合盒转运体A1)、APOC3、LIPA、LIPE(脂肪酶/激素敏感脂肪酶)、PTGER2(前列腺素E受体2)和PTGS2(前列腺素内过氧化物合成酶2)等基因表现皆有呈现向上调控的情形。

We reported that metronomic chemotherapy might be an option for the metastatic ACC of the trachea refractory to radiation and chemotherapy.

在这篇报告中，我们发现对於放射线及化学治疗反应不佳的转移性气管腺样囊状癌，节拍式化学治疗或许是一个选择。

Methods:By immunochemical EnVision method, the expression of HBME-1,CK19 and Galectin-3 were detected in 55 cases of papillary thyroid carcinomas,24 follicular adenomas, 20 multinodular goiters and 10 Hashimoto's thyroiditis.

采用免疫组化检测55例甲状腺乳头状癌、24例甲状腺腺瘤、20例结节性甲状腺肿和10例桥本甲状腺炎中HBME-1、CK19和Galectin-3的表达。

Cholesterol polypoid was the most common in the pathological types, accounting for 85% of nonneoplasm nature.

胆固醇息肉占非肿瘤性息肉的 85 %，肿瘤性息肉多为接近 1 0mm的单发病灶，3例胆囊癌中 2例为腺瘤癌变。

These 375 patients had a median age of 50.57±10.46(range,19-72) with 87.4%HBsAg positive and 4.3%anti-HCV antibody positive;The apparent peak incidence age was 40～60 years old,and the ratio of male to female was 10.7:1;The 3 and 5 year postoperational survival rate were 52%and 38%;The tumour numbers(p=0.000),tumor size(p=0.025),histological pattern (p=0.000),nuclear features(p=0.000),differentiation(p=0.001) and vascular invasion(p=0.000) were significantly correlated with prognosis.The postoperational survival time of thin trabeculae pattern,compact pattern and pseudoglandular pattern were significantly longer than that of thick trabeculae, scirrhous pattern,and solid patternp＜0.009the postoperational survival time of 1 and 2 grade based on nuclear features were significantly longer than that of 3 and 4 grades(p=0.000The small cell variant,osteoclast-like giant cell variant, and spindle cell variant were mainly composed of thick trabeculae pattern and solid pattern,which were significantly different from that of clear cell variant.

结果1。本组资料显示肝细胞癌发病年龄19～72岁，平均50.57±10.46岁，发病高峰年龄40～60岁，男女比例为10.7：1；HBsAg87.4%，anti-HCV抗体4.3%；术后3年生存率为52%，5年生存率为38%；肿瘤数目(p=0.000)、肿瘤大小(p=0.025)、组织学结构类型(p=0.000)、核分级(p=0.000)、分化程度(p=0.001)及血管浸润均(p=0.000)与预后明显相关；其中组织学结构类型中细梁状型生存时间与致密梁状型和腺样型无明显区别(p＞0.05)而明显高于粗梁状型、实性型和硬化型(p≤0.009)，硬化型生存时间与实性型之间无明显区(p＞0.05)而明显低于其余各型p≤0.006核分级1级与2级生存时间无明显区别(p＞0.05，核分级3级与4级生存时间无明显区别(p＞0.05)，而核分级3级生存时间明显低于2p=0.000小细胞型、巨细胞型和梭形细胞型主要由实性型和粗梁状型组织学结构类型构成，明显不同于透明细胞型(主要由细梁状型和粗梁状型构成(p≤1.006)。2。

Department of Oral Biology, Qindu Stomatological College, Fourth Military Medical University, Xi an 710033, China

目的：研究雌激素对人涎腺黏液表皮样癌血管生成的影响。

MT1-MMP may be an effective target for thermoradiotherapy in anti-ACC treatment.

研究结果提示，MT1-MMP是热放疗抑制腺样囊性癌侵袭转移等恶性行为的有效靶点。

Objective: To enhance the recognition of imaging of thymic neoroendocrine carcinoma.

目的：提高对胸腺神经内分泌癌的影像学表现的认识。

METHODS Estrogen receptorand progesterone re-ceptorof the thyroid tissues were determined by using enzyme-linked affinity histochemical technique in100patients with different thyroid diseases.Among them,35patients with thyroid cancer,19thyroidoma,22tuberous thyrocele and24with normal thyroid tissue.

采用酶联亲合组化法对手术切除的甲状腺标本100例进行ER及PR检测，其中甲状腺癌35例，甲状腺腺瘤19例，结节性甲状腺肿22例，正常甲状腺组织24例。

I didn't watch TV last night, because it .

昨晚我没有看电视，因为电视机坏了。

Since this year, in a lot of villages of Beijing, TV of elevator liquid crystal was removed.

今年以来，在北京的很多小区里，电梯液晶电视被撤了下来。