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However, the induced antibody from these mice had weaker cross-reaction with the SARS-CoV S protein, and did not neutralize HIV pseudotyped with SARS-CoV S protein.

然而,该重组腺病毒诱导的抗体和SARS冠状病毒S蛋白仅有弱的交叉反应,且不能中和假型SARS病毒的侵染。

The team, led by Eric Kremer of the University of Montpellier in France, examined why people participating in the STEP vaccine trial who had previously been exposed to a cold virus, adenovirus 5, seemed more likely to become infected with HIV-1 than those who hadn't been exposed to the virus (see ' HIV vaccine may raise risk ').

法国的蒙特利尔大学里的EK和他的带领的团队做了这样的一个"分步疫苗试验"的研究,试验为什么那些曾经暴露于被冷冻腺病毒5的受试者比那些从未没有接触过这些病毒的人更加容易感染艾滋病病毒。(见文章《人类免疫缺陷病毒疫苗有可能引发灾难》)。

For several years, researchers have looked at a possible link between obesity and this common virus, called adenovirus-36, from a family of viruses that cause colds and pinkeye in people.

在过去的几年里,研究者调查了肥胖与叫做腺病毒-36普通病毒之间的可能联系,这种病毒来自可以导致人类感冒的病毒家族。

Some factors, like expression stage in adenovirus and expression level in influenza, is also prominent in some viruses. In HPV and HIV, the hydropathy of the protein also plays its role, although not the main factor.

某些选择因素如腺病毒中基因的表达时相、流感病毒中基因的表达水平是比较明显地影响病毒密码子选择的因素,而在HPV和HIV基因所编码的蛋白的疏水性尽管对于病毒的密码子使用有影响,但不是最主要的因素。

The results demonstrate that wtp53 transgene expression sensitizes human lung adenocarcinoma in vivo to irradiation.

研究结果表明腺病毒载体可有效的将外源wtp53基因转入人肺腺癌细胞,wtp53可以抑制人肺腺癌细胞的恶性生长,Ad一wtp53瘤内注射结合放疗可以提高人肺腺癌细胞的放射敏感性。

There were many apoptosis and little necrosis in the group of Ad-p53 , there were little apoptosis and many necrosis in the group of radiation. CONCLUSION: The results demonstrate that wtp53 transgene expression sensitizes human lung adenocarcinoma in vivo to irradiation.

研究结果表明腺病毒载体可有效的将外源wtp53基因转入人肺腺癌细胞,wtp53可以抑制人肺腺癌细胞的恶性生长,Ad一wtp53瘤内注射结合放疗可以提高人肺腺癌细胞的放射敏感性。

PURPOSE: To investigate the combined effects of adenoviral-mediated p53(Ad-p53) transgene expression and irradiation response in nude mice models of lung adenocarcinoma (A549 and GLC-82).To determine whether wtp53 sensitizes cells to radiation independently of their p53 status and to investigate the interaction mechanism.

目的:本研究筛选了P53基因状态不同的两种人肺腺癌细胞系A549及GLC-82,分别建立裸鼠人肺腺癌移植瘤模型,使用E1复制缺陷型重组腺病毒介导的野生型P53基因瘤内注射治疗,观察其放射增敏作用并探讨其机制,同时比较不同P53基因状态对治疗的影响,为临床开展基因放射治疗提供实验依据。

He played key roles in the discovery of the cold-producing adeno-viruses, the hepatitis viruses and the cancer-causing virus SV-40, among others.

对于导致感冒的腺病毒、肝炎病毒和致癌的SV-40病毒以及其他病毒的发现,他起到了关键作用。

Adenoviruses, Simplex Herpes Viruses and human reoviruses are all used as oncolytic virus.

溶瘤病毒有多种,目前研究较多的有溶瘤型的腺病毒、单纯疱疹病毒和人呼肠孤病毒等。

Results: The titer of Ad-PKG Ⅱ was 5×l0^9 pfu/ml. The PKG Ⅱ protein expression in Ad-PKG Ⅱ infected CS-54 cells was significantly increased in comparison with that in the control cells; in gastric cancer line BGC-823, PKG Ⅱ significantly inhibited the EGF induced activation of ERK.

结果:重组腺病毒滴度达5×10^9pfu/ml,蛋白质印迹法检测显示重组腺病毒感染CS54细胞后使其PKG Ⅱ表达明显增高;在BGC-823胃癌细胞株,PKG Ⅱ对EGF导致的ERK的激活有明显抑制作用。

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