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Objective To study the morphologic changes with age in thymocytes and to explore the effect of luteolin on the aging changes in thymocyte morphology,immunity and anti-oxidation activity in aged mice.

目的 探讨不同年龄胸腺细胞在胸腺内区域性分布的形态学变化,研究木犀草素对衰老大鼠胸腺形态学及免疫功能和抗氧化能力的影响。

At high magnification, the neoplastic glands of adenocarcinoma have crowded nuclei with hyperchromatism and pleomorphism .

在高倍镜下可见腺癌内有腺体,腺体较多,腺体内癌细胞内的色素较多,癌细胞呈同质异型性。

The level of cAMP in cell depends on adenyl cyclase and phosphodiesterase .

细胞内的环磷酸腺苷的水平取决于腺苷环化酶和磷酸二酯酶。

Methods The clinical data of 8 patients of biliary cystadenoma and cystadenocarcinoma, 3 males and 5 females, aged 55.8 (26 ~ 71 ), were analyzed retrospectively.

方法回顾分析8例肝内胆管囊腺瘤和囊腺癌的临床病理表现、诊治经验并结合文献资料进行讨论。

The pressor effect of adenosine was due to carotid body cheoreceptor activation. However, a slight increase of ABP induced by intracarotid bolus injection of adenosine following the section of carotid sinus nerves was observed in a few rats, which implied that the central effect might be involved in the pressor effect of adenosine. The delayed effect of adenosine may be attributed to the direct actions (including the negative chronotropic action, thenegative dromotropic action, the negative inotropic action and the vasodilator effect) of adenosine on the heart and blood vessels.

前一效应主要与颈动脉体化学感受器的激活有关,但在少数动物,颈动脉内注射腺苷的升压效应在切除窦神经后并未完全消除,表明腺苷有可能进入神经中枢而发挥作用;后一效应可能由腺苷直接作用于心脏和血管,通过其负性变力、变时、变传导和血管扩张等作用,导致心脏自律性降低,输出量减少和外周阻力下降。

Methods The promoter of hTERT and Cox-2 was subcloned from human genomic DNA, then ligated to shuttle vector pd306 which contains the Ela and Elb gene of adenovirus to control the expression of Ela and Elb,respectively.

将hTERT和Cox-2启动子从人类白细胞基因组中亚克隆出来,并将启动子分别插入到腺病毒穿梭载体pd306上的E1A和E1B基因前,使hTERT和Cox-2启动子分别调控腺病毒必须基因E1A和E1B的表达,再将构建后的pd306和腺病毒的骨架质粒BHGE3在Ad293细胞内进行同源重组,并用重组后的病毒感染Hela细胞检测病毒对肿瘤细胞的杀伤力。

Was simultaneously injected into cisterna magna at the second injection blood in the presence of subarachnoid blood. At 2 to 4 days, GFP was expressed in leptomeninges over the brain stem, cortex and cerebral arteries, smooth muscle cells of small vessels were occasionlly transduced. GFP was expressed in adventitia of spastic basilar artery on days 2 (day 5 after first injection blood) after injection 〓, but was undetectable by days 4, transgene was not expressed in medial or intimal layers. The prensence of subarachnoid blood can not prevent access of adenovirus to vessels and transgene expression.

注入腺病毒载体后2天(初次注血第5天)行荧光显微镜、免疫组织化学和RT-PCR检测,结果在颅内大血管如基底动脉的外膜可见外源基因的表达,而外源基因不能转移至血管中膜和内膜,4天时(初次注血第7天)基底动脉的外膜中外源基因表达消失;注入腺病毒载体后2~4天,外源基因可以有效转移至颅底软脑膜细胞,小血管外膜和平滑肌层也可见外源基因的表达,表明蛛网膜下腔内的血凝块不能阻止腺病毒载体介导外源基因转移至颅内血管。

MR may obviously demonstrate the entire image if hepatobiliary cystadenoma, the mural nodus form and corpora mammillaria solid lesions suggest canceration. Conventional MR sequences combine with dynamic enhancement and MRCP possese fairly diagnostic value to hepatobiliaty cystadenoma.

MR能明确显示肝内胆管囊腺瘤的整体影像的特征性表现,若囊壁上有结节或乳头状肿块提示局部有癌变,MR常规扫描结合动态增强及MRCP成像对肝内胆管囊腺瘤具有很高的诊断价值。

The numbers of ANAE(superscript +) T cells in the spleen and head kidney were more than those of thymus, therefore, it is suggested that the matured T cells are emigrated thymus to spleen and head kidney.

实验结果进一步证明了胸腺中的T细胞多为不成熟的T细胞,此外,还含有大量的IgM细胞;而脾脏、头肾内的ANAE T细胞多于胸腺,推测胸腺成熟的T淋巴细胞迁移到头肾和脾脏。

The border of hyperplastic nodal which had no pathological nuclear mitoses, invasion and necrosis was clear. The staining of 8 antidodies had not significant value to the differential diagnosis between basal cell adenocarcinoma and adenoma of prostate.

而基底细胞腺瘤内增生的基底细胞异型性不明显,无病理性核分裂象,增生结节周界清,无浸润性边缘和坏死。8种抗体的免疫酶标记在前列腺基底细胞腺癌和腺瘤的鉴别诊断上无显著性意义。

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