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We conclude that (1) S100A1 is a specific and sensitive immunohistochemical marker to differentiate nephrogenic adenoma from prostatic adenocarcinoma;(2) AMACR immunostaining does not seem to be a useful marker in distinguishing between these 2 lesions;(3) given that both S100A1 and AMACR have been reported to be expressed in renal tubular cells and in a subset of renal cell neoplasms, our findings confirm the histogenetic relationship between nephrogenic adenoma and renal tubular epithelium.

我们总结认为:(1)鉴别肾源性腺瘤和前列腺腺癌,S100A1既特异又敏感;(2)AMACR免疫染色鉴别这两种病变,效用不佳;(3)文献报道S100A1和AMACR均表达于肾小管上皮和部分肾细胞肿瘤,在此前提下,我们的结果证实了肾源性腺瘤和肾小管上皮之间的组织发生关系。

The canceration of adenomas was found in 3 out of 14 benign adenomas in 2 out of the 4 cases (50%) of homochronous multiple carcinoma.

2腺瘤癌变的诊断标准:①同一病灶中,原来比较正常的腺管被覆上皮被癌细胞取代。

Results Although overexpression of P53 protein was not detected in normal eyelid cutaneous epithelium, meibomian gland and mild epithelial dysplasia, the positive rate of P53 increased in degree in moderate and severe dysplasia, carcinoma in situ and invasive tumors, and PCNA labeling index progressively increased too. Overexpression of P53 protein was detected in 30/53 cases of basal cell carcinoma, 16/32 cases of squamous cell carcinoma, 10/17 cases of meibomian gland carcinoma, and the intensity of P53 protein immunostaining increased with the lowering in the degree of histological differentiation.

结果 在正常眼睑皮肤、睑板腺及轻度不典型增生眼睑上皮中,未见P53蛋白表达,而中、重度不典型增生,原位癌,浸润癌中,P53蛋白阳性表达率逐渐增高,其 PCNA指数也有增加趋势。30/53例基底细胞癌(basal cell carcinoma,BCC)、16/32例鳞状细胞癌(squamous cell carcinoma,SCC)、10/17例睑板腺癌中,P53蛋白阳性表达;同时,随着肿瘤组织分化程度的降低,P53蛋白阳性表达程度有逐渐增高的趋势。

Results Although overexpression of P53 protein was not detected in normal eyelid cutaneous epithelium, meibomian gland and mild epithelial dysplasia, the positive rate of P53 increased in degree in moderate and severe dysplasia, carcinoma in situ and invasive tumors, and PCNA labeling index progressively increased too.

结果 在正常眼睑皮肤、睑板腺及轻度不典型增生眼睑上皮中,未见 P53蛋白表达,而中、重度不典型增生,原位癌,浸润癌中, P53蛋白阳性表达率逐渐增高,其 PCNA指数也有增加趋势。30/53例基底细胞癌(basal cell carcinoma,BCC)、16/32例鳞状细胞癌(squamous cell carcinoma,SCC)、10/17例睑板腺癌中, P53蛋白阳性表达;同时,随着肿瘤组织分化程度的降低, P53蛋白阳性表达程度有逐渐增高的趋势。

Results:There is a close positive correlation between myoepithelial cell differentiation and glandular cell maturation and the ratio of myoepithelial cells to glandular endpieces area was decreased.

结果:实验结果提示,小鼠泪腺肌上皮细胞从出现到成熟的形态变化,与腺细胞内的分泌颗粒从出现到增多是同期发育的,泪腺腺房与肌上皮细胞的面积比率呈减小趋势。

At day 20, some of the acini collapsed, and the epithelial cells of the duct were damaged.

由10μg·L-1 B\P处理20d时,在鳃回血管中发现血细胞坏死后残留的固缩细胞核,鳃丝的上皮细胞排列不规则甚至断裂,部分消化腺泡崩解,鳃丝结构和消化导管上皮结构损害严重;消化盲囊组织结构的损伤比鳃更为严重。

Results 17β-HSD type 2 was found in the cytoplasm of tumor cells in 5.3% of cases.In adjacent non-malignant tissues,82.9% of cases were positive and the enzyme was detected in the cytoplasm of epithelial cells of the acini and ducts.

结果:2型17β-HSD在乳腺癌细胞的细胞浆中有表达,阳性率为5.3%;在癌旁非恶性乳腺组织腺泡上皮细胞以及导管上皮细胞的细胞浆中表达,阳性率为82.9%。

Results The expression of endogenous LN was found in the basement membrane of epithelium, glands and blood vessels in uterine endometrium of both estrus and early pregnancy. And its was faint that LN present in basement membrane as the implantation occurs, but the LN immunostaining in the epithelial cells of endometrium was stronger. The exogenous LN has no obvious influence on blastocyst attachment and implantation. LN-antibody intra-uterine injection showed significant repressing effect on mouse blastocyst implantation.

结果 动情期及妊娠早期小鼠子宫内膜内源性LN在上皮和腺基膜及血管内皮基膜均有表达,并随着植入的发生基膜的LN表达减弱,而内膜上皮中LN免疫染色逐渐增强;外源性LN对小鼠胚泡粘附与植入子宫内膜不产生明显影响,层粘连蛋白抗体明显抑制小鼠胚泡着床。

By incorporation of tritiated thymidine or 5-bromodeoxyuridine and using them as the markers, we found that the basal cells, Clara cells and type II alveolar epithelial cells in the pulmonary tissues may in some way behave like stem cells and can eventually differentiate into respiratory tract epithelium.

通过应用cells in induced group cultured for 2 weeks 标记的胸腺嘧啶(3H-TdR)或5-溴脱氧尿核苷的渗入进行标记,发现肺组织的基底细胞、Clara 细胞和肺泡II型上皮细胞可能具有干细胞特征,能最终分化形成气道上皮。

By incorporation of tritiated thymidine or 5-bromodeoxyuridine and using them as the markers, we found that the basal cells, Clara cells and type Ⅱ alveolar epithelial cells in the pulmonary tissues may in some way behave like stem cells and can eventually differentiate into respiratory tract epithelium.

通过应用cells in induced group cultured for 2 weeks von kossa staining)标记的胸腺嘧啶(3H-TdR或5-溴脱氧尿核苷的渗入进行标记,发现肺组织的基底细胞、clara细胞和肺泡Ⅱ型上皮细胞可能具有干细胞特征,能最终分化形成气道上皮。

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从鲍尔点的形成原理出发,分析对称连杆曲线上鲍尔点的产生条件,提出等边机构的对称连杆曲线上有单鲍尔点和双鲍尔点。

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血精的原因很,以良性病变为主。