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The CPT values in the affected leg in patient group were significant higher than those in control group at all frequencies. The CPT values in contralateral leg in patient group were significant higher than those in control group at 5Hz whereas there were no significant differences at 250Hz and 2000Hz. The CPT values in affected leg in patient group were significant higher than those in contralateral leg at 250Hz and 2000Hz whereas there were no significant differences at 5Hz. All the CPT values showed the same linear decrease from the dermatome of the compressed root to the dermatomes of the contralateral neighbor dematom.

在用CPT监测8例腰骶单神经根病组患侧和健侧及与正常对照组的不同直径感觉神经纤维功能的研究中发现压迫皮节和其临近皮节的所有频率CPT值无任何显著性差别;患者压迫侧的2000Hz及250HzCPT值及压迫侧和对侧的5HzCPT值与正常对照组都有显著性差别;患者组5HzCPT值患侧和对侧无差别,其他两组均有显著性差别;不管有无显著性差别,神经根病患者组各皮节三频率CPT值均按照压迫皮节,临近皮节,压迫对侧皮节,压迫对侧临近皮节的顺序减小,说明在腰骶单神经根病中Aβ纤维及Aδ纤维及无髓C纤维均受累。

There were 36 males and 40 females,with the average age of 47.7 years.36 patients presented with sciatica and perineal numbness,11 patients had painless mass and the other 20 were identified due to other causes.Among 67 benign neurogenic tumors,54 were originated from S1-S3 nerves,3 from S4-S5 nerves and 11 from the presacral space without caudal involvement.Giant cell tumor was found in 60 patients,which included 24 males and 36 females,with an average age of 32 years.Upper sacrum(S1-S2) was involved firstly.There were 56 patients(average,37.7 years) diagnosed as other primary benign bone tumors,which included 24 cases of teratomas,epidermoid cyst or dermoid cyst.Other malignant tumors,including chondrosarcoma (17),Ewing′s sarcoma/PNET(14),multiple myeloma(12),lymphoma(6) and osteosarcoma(6) were found in 64 patients.

其中脊索瘤95例,男62例,女33例,平均年龄55.7岁,骶尾区疼痛是主要症状(82例),半数以上患者伴有坐骨神经痛,肿瘤多先累及低位骶骨(S3~S5);神经源性肿瘤76例,男36例,女40例,平均年龄47.7岁,神经纤维瘤43例,神经鞘瘤24例,恶性神经鞘瘤9例,主诉多为坐骨神经痛、会阴部麻木(36例)和无痛性包块(11例),20例患者为查体或其他原因检查时发现,67例骶骨良性神经源性肿瘤起源于S3以上神经者54例,起源于S3以下神经者3例,发生于骶前未累及骶管者10例;骨巨细胞瘤60例,男24例,女36例,平均年龄32岁,腰骶尾部不适(37例)、坐骨神经痛(21例)是主要的临床表现,肿瘤多先累及上位骶骨(S1~S2);骶骨其他原发良性肿瘤及瘤样病变56例,包括畸胎瘤、皮样囊肿、表皮样囊肿共24例;其他原发恶性肿瘤64例,包括软骨肉瘤17例,尤文肉瘤14例,多发性骨髓瘤12例,成骨肉瘤6例等。

It is indicated that back epiphysis loop fracture of lumbosacral vertebrae is the specific pathological feature of adolescent lumbocrural pain.

提示椎体后缘骺环骨折是青少年腰腿痛患者特有的病理改变,由此认为腰骶椎后缘骺环骨折是导致青少年腰腿痛不可忽视的因素之一。

It is indicated that back epiphysis loop fracture of lumbosacral vertebrae is the specific pathological feature of adolescent lumbocrural pain. Therefore, it should be regarded as an important cause of adolescent lumbocrural pain.

提示椎体后缘骺环骨折是青少年腰腿痛患者特有的病理改变,由此认为腰骶椎后缘骺环骨折是导致青少年腰腿痛不可忽视的因素之一。

It is indicated that back epiphysis loop fracture of lumbosacral vertebrae is the specific pathological feature of adolescent lumbocrural pain. therefore, it should be regarded as an important cause of adolescent lumbocrural pai

提示椎体后缘骺环骨折是青少年腰腿痛患者特有的病理改变,由此认为腰骶椎后缘骺环骨折是导致青少年腰腿痛不可忽视的因素之一。

It is indicated that back epiphysis loop fracture of lumbosacral vertebrae is the specific pathological feature of adolescent lumbocrural pain. The refore, it should be regarded as an important cause of adolescent lumbocrural pain.

提示椎体后缘骺环骨折是青少年腰腿痛患者特有的病理改变,由此认为腰骶椎后缘骺环骨折是导致青少年腰腿痛不可忽视的因素之一。

One-stage surgical management by posterior instrumentation and anterior resection plus interbody autografting is an effective method in dealing with lumbosacral spine tuberculosis.

一期后路内固定加前路病灶清除椎体间植骨融合术治疗腰骶段脊柱结核的疗效确切,能达到彻底清除病灶和重建腰骶稳定的目的。

In summary, the present study revealed that Barrington's nucleus and D-region received direct projection fibers from the sacral spinal neurons in lamina I, parasympathetic nucleus and dorsal commissural nucleus; periaqueductal gray also received afferent projections from the lumbosacral spinal cord and sent projection fibers to the Barrington's nucleus and D-region.

上述结果说明:大鼠腰骶髓 I 层、骶髓副交感核和后连合核神经元发出的投射纤维直接终止于 Barrington's 核和 D 区内;导水管周围灰质也接受来自腰骶髓的投射纤维,同时发出纤维终止于 Barrington's 核和 D 区内。

Therefore, in the present study, a retrograde and anterograde experiments were made in the rat to address this issue. After injection of cholera toxin B subunit, a retrograde tracer, into Barrington's nucleus or D-region, some retrogradely labeled neurons were found in lamina I, sacral parasympathetic nucleus and dorsal commissural nucleus of the lumbosacral spinal cord segments. Injection of biotinylated dextran amine into lamina I, sacral parasympathetic nucleus and dorsal commissural nucleus, respectively, a large number of BDA-labeled axon terminals were seen in Barrington's nucleus and D-region.

发现,将逆行示踪剂霍乱毒素 B 亚单位( Cholera toxin B subunit; CTb )注射到 Barrington's 核或 D 区后,在大鼠腰骶髓 I 层、骶髓副交感核和后连合核内分布有一定数量的 CTb 逆标神经元;将顺行示踪剂结合生物素的葡聚糖胺(Biotinylated dextran amine; BDA)分别注射到腰骶髓 I 层、骶髓副交感核和后连合核内后, Barrington's 核和 D 区内出现大量顺行标记的轴突终末。

Lumbarsacral junction tuberculosis treated with this surgical technique can achieve a high satisfactory rate with restoring the spinal stabil ity, arresting the disease early, providing early fusion, correcting the kyphosis and preventing progression of kyphosis particularly if lumbosacral spine tuberculosis is associated with sinus or preoperative diagnosis cannot exclude suppurative spondyl itis.

血常规、血沉、肝肾功正常9 例,2 例肝转氨酶升高。结论前路彻底病灶清除、植骨结合后路器械固定治疗腰骶段脊柱结核具有安全、操作简便、利于恢复脊柱的稳定性、提高植骨融合率、纠正和预防后凸畸形的优点,适用于腰骶段脊柱结核伴窦道及术前诊断尚不能排除化脓性脊椎炎者。

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