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Day puppies were inoculated by abdominal cavity and nasal cavity with CDV,canine distemper patho-sample of duplicating meet with success and through differentdrug of treatment, specific antibody, dexamethasone, causing death by letting. Theresults of pathohistology observation on 14 PID: Control group, the hearts showedcardiac muscle hemorrhage and necrosis, the livers showed a large area of hepatictissue hyperemia, hemorrhage and necrosis, the spleens showed the quantity oflymphocyte grow downwards, the blood vessels of lung congested, congestion andhaemorrhage were serous fluid exudation, the kidneys showed heavy haemorrhageand hyperemia, the cerebrum showed the number of microglial cells of cerebrumincreased.

通过特异性抗体和地塞米松、特异性抗体、地塞米松三种不同的方法治疗后,放血致死,取材作病理切片,观察各组病理组织学变化,结果为:感染后14d阳性对照组的心脏表现为心肌出血、坏死;肝脏表现为肝组织大面积充血、出血坏死;脾脏表现淋巴细胞数量大量减少;肺脏表现为肺泡结构破坏,有坏死灶;肾脏表现为弥漫性的充血出血;大脑表现为胶质细胞增多。

At certain dose, CPQD could keep the weight of the thymus gland and spleen.

复方洋参汤在一定剂量可对抗Cy对免疫器官的减重作用,使脾脏、胸腺的重量恢复至Cy使用前的水平。

Our previous studies have identified an undescribed regulatory DC subset, which were developed from differentiation of mDCs educated by splenic stromal cells.diffDCs secret high levels of IL-10 and NO, and inhibit proliferation of activated CD4+ T cells, suggesting its negative feedback control on the immune response in the late phage.

diffDCs是本室最近发现的新型调节性DC亚群,由mDCs在脾脏基质细胞的作用下分化而来,具有高分泌IL-10和NO、抑制抗原特异性CD4~+T细胞增殖的功能,提示浙江大学博士学位论文中文摘要可能在获得性免疫应答晚期起负性调控作用。

Expression of mutant tumor suppressor gene p53 in egg-type chicken with avian leukosis subgroup J was detected to study cancericidally molecular mechanism of ALV-J. Using immunohistochemistry method of strep avidin-biotin complex, many organs of illed egg-type chickens, involved liver, kidney, ventriculus glandularis, tumor, heart, pancreas, bone marrow, spleen, oviduct, lung, duodenum, thymus and bursa of fabricius were studied.

为了探讨J亚群禽白血病病毒的致癌分子机理,观察蛋用型鸡发生J亚群禽白血病时p53抑癌基因在各脏器中的表达,应用链霉亲和素-生物素-过氧化物酶复合物免疫组化法,研究了蛋用型鸡J亚群禽白血病自然病例的肝脏、肾脏、腺胃、肿瘤、输卵管、心脏、胰脏、骨髓、脾脏、肺脏、十二指肠、胸腺和法氏囊。

This conclusion was further confirmed when effector CD8 T cells were generated in WT mice and adoptively transferred into WT or PFR second hosts on day 7 after infection.

我们还采用了另外一种方式来确认上述结果:在野生型小鼠中回输Thy-1.1~+OTI CD8T细胞并感染,7天后纯化脾脏Thy-1.1~+CD8T细胞,按相同细胞数分别回输到同步感染的野生型C57小鼠或PFR小鼠中,在PFR小鼠中同时回输经活化的野生型或者穿孔素缺陷的NK细胞。

Objective: To study the effect of excessive VitA and Zn intake respectively or unitedly on antioxygenic capability, cell cycle and apoptosis protein in the rat spleen. The study wants to confirm the interaction between VitA and Zn, and provide reasonable foundation for the supplement of VitA and Zn.

目的:研究单独及联合过量摄入维生素A、锌对大鼠脾脏抗氧化功能、细胞周期及凋亡相关蛋白的影响,研究VitA和Zn之间的相互作用,为VitA和Zn的合理补充提供实验依据。

Methods The Cynomorium polysaccharide and Cynomorium water extract were extracted and prepared chewable tablets. Wistar rats were randomly divided into normal control, aging model, VitE, Cynomorium polysaccharide chewable tablets and Cynomorium water extract chewable tablets groups. Dgalactose was injected to establish the aging model. After drug intervention, the proliferation activity of rat spleen lymphocytes stimulated by ConA was detected by MTT assay and the spleen index was measured. The pathological morphological changes of spleen were observed. The activity of superoxide dismutase, the content of malondialdehyde and nitric oxide in serum of rats were detected.

提取并制备锁阳多糖、水提取物咀嚼片;Wistar大鼠随机分为空白对照组、衰老模型组、维生素E对照组、锁阳多糖组、水提物组,以D半乳糖建立衰老大鼠模型,药物干预后,MTT法检测各组大鼠脾淋巴细胞对ConA刺激的增殖能力,检测各组大鼠脾脏指数,观察脾组织的病理形态学变化;并检测各组大鼠血清中超氧化物歧化酶活性、丙二醛及一氧化氮的含量。

Staining and observing shows that the most pathological changes were interstitial pneumonia and hemorrhagic pneumonia, typical nonsuppurative encephalitis, and neurogangliitis et al. The lymphoid tissue was necrosis, and the amount of lymphocytes was reduced. The pathological changes of the positive cells, especially the epithelial cells were swell, denaturization and hyperplasy to the extent.

H.E。染色观察显示,病理组织学变化主要表现为间质性肺炎和出血性肺炎、典型的非化脓性脑炎、神经节炎等;淋巴结、扁桃体和脾脏等组织内淋巴细胞坏死、数目减少;有阳性反应的细胞,特别是阳性上皮细胞呈现不同程度的肿胀、变性、增生等病理变化。

The immuneregulating action that briefed on the electropuncture further regulated each other throughthe neural peptide / neurotransmitter, hormone and CK. 6Function laws, which compare point: Dazhui is good at suppressing theinflammation, while Mingmen is strong to the regulating immune function; it is Feixuethat has regulating action too.

比较腧穴的免疫调节作用规律:大椎穴的抗炎治疗作用(如足爪肿胀率、下丘脑 CRH 含量,血清 TNFα含量)较强,命门穴对于免疫调节作用(如脾脏 T、B 淋巴细胞转化率、IL-2 活性、肾上腺 IL-2 含量等)较强,非穴也具有一定的抗炎免疫作用,但弱于大椎穴及命门穴。

The change of general physiological characters, D-xylose excretion, activity of amylase in serum, stomach emptying and enterokinesia speed, contractile activity of small intestine in vitro, morphological change of gastrointestinal mucosa, gastrin content in serum, spleen index, thymus index were observed.

实验主要观察了动物的一般体征和消化吸收功能的变化,测定的指标有:D—木糖排泄率、血清淀粉酶活性、胃排空速率、肠推进速率、离体小肠张力、胃肠粘膜形态、血清胃泌素含量、脾脏指数和胸腺指数。

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