脾肾的

Not only it impairs patients" genital health and Quality of life, but also is associated with an increased risk of type 2 diabetes, endometrial carcinoma, hyperlipemia, hyperpiesia, cardiovascular and cerebrovascular events. Up to now, precise pathogenesy of PCOS is yet unknown. The modern medicine indicates the etiopathogenisis of PCOS related to hereditism, endocrinology, immunology, metabolism and so on. The main features are hyperandrogenism and hyperinsulinemia, the correlation and between the above factors and how they inference PCOS are still unclear. In the view point of Traditional Chinese Medicine ,PCOS classifies to "menopathy","infertility" and "Zhengjia , its occurrence exists a close relationship with dysfunction of liver, kidney, spleen and further inducing deficiency, sputum, sluggish stagnant and fire. Many scholars insist that pathogenesis of PCOS is a renal deficiency plus phlegmatic hygrosis. However, after many years clinical observation.

随着研究的不断深入，PCOS日益显示出其复杂性和重要性；他不仅影响到患者的生殖健康及生存质量，而且其异常的激素环境使该类患者对子宫内膜癌、高血压、高血脂及心脑血管意外等病发生危险明显增加；但目前该病的确切发病机制尚不十分清楚，现代医学认为其病因涉及到遗传、内分泌、免疫、代谢等多个方面，以高雄激素血症与高胰岛素血症为主要特征，二者在PCOS发病中的确切作用，目前尚不清楚；PCOS相当于祖国医学的"月经病""不孕""癥瘕"等范畴，本病的发生与肝、肾、脾功能失调导致虚、痰、瘀、火有关。

Cell proliferation and viability were assayed 48h after transfection, and MDA-7 demonstrated selective inhibition of tumor cell growth, inhibitory rates of A549, Hela and HepG2 cell lines were 25%, 20% and 19%, respectively, but had no significant effect on human fetal kidney derived 293 cell line. Hela cell was screened by G418 for 2 weeks after pcDNA3-MDA-7 and monolayer colony was counted, its monolayer colony formation was 30% of cells transfected with pcDNA3. 0 vector. CMV-driven MDA-7 adenovirus vector was constructed. 293 showed no significant apoptosis during adenovirus packaging and the unpurified adenovirus titer was about 1×10〓pfu/ml. Cos 7, A549, Hela, HepG2 and Hep3B cell was infected with Ad-GFP at different MOI.

二。黑色素细胞分化相关蛋白-7（MDA-7）的克隆及功能研究：利用RT-PCR方法从5月龄人胚胎脾细胞扩增MDA-7的编码序列，经测序鉴定序列与文献报道一致后，与真核表达载体pcDNA3.0连接，构建pcDNA3-MDA-7表达载体，瞬时转染293、A549、Hela和HepG2细胞后抽提细胞总RNA，RT-PCR结果显示表达载体可介导MDA-7在不同细胞系中有效表达；转染48h后测定细胞增殖和活力，MDA-7可选择性抑制肿瘤细胞的增殖，对A549、Hela和HepG2细胞的抑制率分别为25％、20％和19％，但是对人胚肾来源的293细胞生长无明显影响。pcDNA3-MDA-7载体转染Hela细胞后，以G418筛选2周后计数单层细胞集落形成数，计数仅为转染pcDNA3.0空载体的细胞的30％左右。

There were portal collateral vessels around the main portal vein in 8 patients and among them, there was 1 patient with the varix of gallbladder wall, 2 with gastroepiploic varix, 1 with varix on the bile duct wall, 1 with open of the retroperitoneal-paravertebral vein and the splenorenal vein, and 1 with open of the retroperitoneal-paravertebral vein.

结果 在门脉闭塞后，引起相应血管的纡曲扩张及侧支血管的形成，其中有门脉周围形成门－门侧支循环，胆囊壁静脉的曲张，胃网膜静脉的增粗纡曲，胆管壁静脉的纡曲扩张，腹膜后椎体旁侧支血管的开放，脾－肾静脉短路的开放，胃底食管静脉的曲张。

Not only it impairs patients" genital health and Quality of life, but also is associated with an increased risk of type 2 diabetes, endometrial carcinoma, hyperlipemia, hyperpiesia, cardiovascular and cerebrovascular events. Up to now, precise pathogenesy of PCOS is yet unknown. The modern medicine indicates the etiopathogenisis of PCOS related to hereditism, endocrinology, immunology, metabolism and so on. The main features are hyperandrogenism and hyperinsulinemia, the correlation and between the above factors and how they inference PCOS are still unclear. In the view point of Traditional Chinese Medicine ,PCOS classifies to "menopathy","infertility" and "Zhengjia , its occurrence exists a close relationship with dysfunction of liver, kidney, spleen and further inducing deficiency, sputum, sluggish stagnant and fire. Many scholars insist that pathogenesis of PCOS is a renal deficiency plus phlegmatic hygrosis. However, after many years clinical observation.

随着研究的不断深入，PCOS日益显示出其复杂性和重要性；他不仅影响到患者的生殖健康及生存质量，而且其异常的激素环境使该类患者对子宫内膜癌、高血压、高血脂及心脑血管意外等病发生危险明显增加；但目前该病的确切发病机制尚不十分清楚，现代医学认为其病因涉及到遗传、内分泌、免疫、代谢等多个方面，以高雄激素血症与高胰岛素血症为主要特征，二者在PCOS发病中的确切作用，目前尚不清楚；PCOS相当于祖国医学的&月经病&&不孕&&癥瘕&等范畴，本病的发生与肝、肾、脾功能失调导致虚、痰、瘀、火有关。

There are many complex factors, such as age, environmental, social, psychological, personal factor and human diseases, etc., affecting the development of insomnia symptoms. Insomnia is one kind of neurology/psychiatry diseases, due to brain overstrains and stresses in the nerve center system, in Western Medicine, while there are approximately two factors that can cause the insomnia symptoms, including the anti-pathogenic- qi deficiency and the pathogenic-factors invasion in Traditional Chinese Medicine.

失眠的原因有年龄、环境、社会心理、身体疾病等繁多复杂因素所造成，西医学认为失眠是由大脑压力所造成脑与神经所支配命令的自律神经系统降低或失去其调整身体功能作用之中枢神经系统失调的疾病症状，然而，中医学的失眠病因病机可概括为正虚、邪扰两种，其中正气虚涉及心、脾、肝、胆、肾、胃等脏腑，邪气扰则以痰、热、火、饮、食为多，失眠的病因主要有脏腑虚损、精血不足、神魂失养、七情所伤、内邪滞扰、外邪所感、思虑劳倦太过或暴受惊恐，亦可因禀赋不足、房劳久病或年迈体虚等所致；失眠的主要病机在於阴阳及气血失和，脏腑功能失调，进而神明被扰、神不安舍所致。

F951 distributes extensively into tissues,but the relative affinity varies enormously, being higher for kidney, liver, spleen and bone marrow and lower for heart, lung, brain, intestine, skin, fat and reproductive gland. At about 2 hours postdose, the concentrations of F951 reached the maximums and began to reduce slowly.

结果显示，F951在小鼠体内的分布不均匀，在肾、肝、脾、骨髓中分布浓度明显高于其它器官，在给药后8小时内单位重量组织中的F951含量教高，以后开始缓慢下降；F951在小鼠的心、肺、脑、肠、皮肤、脂肪、生殖腺中也有低水平的分布。

Immune cells were separated from blood and head kidney of silver carp and immunestained with fluorescein-labbled LPS and mouse-anti LPS antiboby.

对银鲫接种从鱼类致病菌中提取的脂多糖后，观察了LPS在鱼体内的分布，获得了进入鱼体内的LPS主要是分布在鱼体的肾、脾和肝等免疫组织中、而且在肾脏中消失的最慢的结果。

The two can cause ultrastructural pathogenesis widely in many organs and tissues such as hepar, pancreas, lien, ren, pulmo, cerebral, cerebellum, cor, muscular and so on, of them ,caused by i~olates YG97 and Y98 more obvious in epithelial cells of digestive tract and unobvious in epithelial cells of respiratory tract ,but ultrastructural pathogenesis caused by NDV strain F48E8 ,more obvious and more serious in glandularis and muscularis ventriaculi and in epithelial cells of respiratory tract .

将鹅源分离株YG_(97)、鸡源分离株Y_(98)和NDV强毒株F_(48)E_8感染SPF鸡，运用扫描电镜和透射电镜观察该二株病毒对机体细胞的影响，结果显示三株禽副粘病毒均引起机体肝、胰、脾、肾、肺、小脑、大脑、心和肌肉等实质器官组织细胞的超微病变，其中YG_(97)和Y_(98)引起消化道粘膜上皮细胞发生微绒毛脱落、纤毛脱落、分泌颗粒增多、细胞游离面破溃等显著的超微病变，引起气管粘膜上皮细胞的不显著超微病变；F_(48)E_8强毒株引起胃粘膜显著而严重的超微病变；还引起气管粘膜上皮严重的超微病变。

The ground of anatomy was laid by Vesalius in the 16th century (1543). Subsequently, Harvey discovered blood circulation in 1616. The invention of microscope enabled people to extend the observation further. Malpighi discovered capillaries (1616), bridging the gap between artery and vein. Meantime, the microscopic structures of lungs, spleen, kidneys, liver, skin and many other organs were revealed gradually. This is an excellent example how a technical breakthrough can contribute to the advancement of biomedical science.

自从 Vesalius 在 16 世纪(1543)奠定了人体解剖学的基础而 Harvey 在 17 世纪中叶(1616)宣布血液大体循环的发现之后，由於显微镜的发明，使得 Malpighi 能在 17 世纪中叶(1616)发现了微血管，将大体循环的动脉与静脉两系统联结起来，同时也对肺、脾、肾、肝、及皮肤的显微构造开始有了概念，这可以说是科技对医学进步影响最早的范例。

As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸，那乌黑、忧郁的眼睛，她便会相信，他一定作过不幸的爱情的受害者。

Maybe they'll disappear into a pothole.

也许他们将在壶穴里消失