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The microstructure changes were mainly vasodilation and hyperemia in those organs,especially in the lung.The heart,liver,kidney,pancreas and cerebrum appeared different degree denaturation and a few lymphocyte and monocyte infiltration;but the lymphocytes in the immune-organ spleen and burse decreased.

结果如下:1。显微结构变化主要表现为:各器官的血管扩张、充血,以肺脏尤为严重,并见少量淋巴单核细胞浸润,同时心、肝、肾、胰和大脑均呈现不同程度的变性;而免疫器官脾、法氏囊则主要表现为淋巴细胞数量减少。

Results In the spleen of SARS patients,splenic corpuscle and periarteri...

动脉周围淋巴鞘的数量减少90·39%;脾小体减少80%左右,有的甚至完全消失;脾红髓广泛出血坏死。

The emulsion plays an important role of effectively reducing the side effects of harmine in nervous system.

结果:静脉乳剂可显著提高放射性在肝、脾、淋巴器官的分布,降低放射性向脑组织的转运。

Immunohistochemical localization of inhibin α-subunit in normal mature rats was carried out by using Strept Avidin-Biotin-Peroxidase Complex .The results showed that there was positive immunoreactivity of the McAb to inhibinα-subunit in heart ,kidney , spleen , lymph ,adrenal gland and pancreas cells. It indicated that inhibinα-subunit existed in the above tissues , But no positive sites were seen in hypothalamus, pituitary, lung and liver, that means they have no inhibinα-subunit. Compared with the ovariectomized rats, the hypothalamus and pituitary of the rats injected with inhibin-α fragment(1~32)showed an positive reaction, suggesting that inhibin α-subunit could pass through the blood-brain barrier .

用链霉亲和素-生物素-过氧化物酶(Strept Avidin-Biotin-Peroxidase Complex, SABC)免疫组织化学方法,以抑制素α亚基单克隆抗体对正常雌性性成熟大鼠各组织的抑制素α亚基进行定位观察,结果显示:⑴大鼠心脏、肾、脾、淋巴、肾上腺、胰腺均呈阳性反应,表明存在抑制素α亚基;下丘脑、垂体、肝脏和肺组织呈阴性反应,表明其不存在抑制素α亚基;⑵与去卵巢大鼠相比,外源注射抑制素α(1~32)片段的大鼠其下丘脑和垂体出现阳性反应,说明抑制素α亚基能通过血脑屏障。

Objective To investigate the expression of Syk and VEGF-C in pancreatic cancer and relation to lymphatic metastasis.

目的 探讨脾酪氨酸激酶和血管内皮生长因子-C在胰腺癌中的表达变化及其与淋巴转移的关系。

MTT colorimetry was used to detect the influence of Rg3 on lymphocyte transformation function and NK cytotoxicity. The activity of IL-2 was detected by lymphoblast proliferation assay and IFN-γ by cytopathic effect inhibition.

MTT法检测Rg3对小鼠淋巴细胞转化功能和NK细胞毒活性的影响,鼠脾T淋巴母细胞增殖分析法测定上清中IL-2活性,细胞病变抑制法测定IFN-γ活性。

Results In the medium and high dose F0 groups, it was observed that the atrophy and incrassation of seminiferous tubule, decrease of spermatogenesis, hyperplasia of interstitial tissue, especially in high dose groups spermatozoon abnormality and nucleolus concentration in the rats testis after DU ingestion for 14 months. The changes became more severe with the prolongation of DU ingestion. Such changes occurred in filial rats (F1) after DC ingestion for 5 months. In the medium and high dose F0 groups, it was observed that a little atrophy of kidney glomerulus, hyperplasia of interstitial tissue after DC ingestion for 14 months, and kidney glomerulus fibrosis happened after DC ingestion for 20 months, such changes occurred in filial rats (F1) after DC ingestion for 5 months In the medium and high dose F0 groups, splenic germinal center and periarterial lymphatic sheaths were hyperplasia , companies with lymphopoiesis after DC ingestion for 7 months, splenic white pulp became more small and sparse after DC ingestion for 20 months.

结果 F0代的中、高剂量组大鼠摄入贫铀14个月后可见雄性的精曲小管萎缩,管壁增厚呈空虚网状,生精细胞层次减少,间质细胞增生,但仍见有精子生成;高剂量组可见到精子呈异型性改变,细胞核浓缩深染,且随着摄入时间延长改变愈趋明显;F1代大鼠摄入贫铀5个月后就有上述改变且更为严重。F0代中、高剂量组大鼠摄入贫铀14个月后肾小球轻度萎缩,间质增生明显,20个月时肾小球萎缩纤维化;F1代大鼠摄入贫铀5个月后就有上述改变。F0代中、高剂量组摄入贫铀7个月时脾脏生发中心和淋巴鞘增生,淋巴母细胞增生活跃,20个月时脾小体减少,生发中心稀疏;F1代大鼠摄入贫铀早期和晚期有类似改变。F0和F1代高剂量组摄入贫铀早期肝脏有炎症细胞浸润,晚期骨髓有核细胞减少,脂肪细胞增加。

In the control animals,the GAP-43-LI nerve fibers were found mainly distributed in association with vascular plexuses,with minor extension into the parenchyma of the inner zone of the periarterial lymphocyte sheath.In the immunized animals,in addition to denser vascular plexuses,more fibers appeared in the outer zones of periarterial lymphocyte sheath,the marginal zone,and the red pulp,all known to be the sites of active immune response.

于对照动物,脾GAP-43-LI神经纤维主要分布于血管周围,少量伸入动脉周围淋巴鞘的脾基质中,而在免疫刺激的动物,不仅血管周围的神经纤维明显增多,动脉周围淋巴鞘外层、边缘区和红髓等免疫应答活跃的部位也出现许多神经纤维。

The results were as follows: Compared with control group, the weight and the relative weight of thymuses, bursas of Fabricius and spleens of experiment group increased significantly(P<0.05) or extremely significantly(P<0.01). In experiment group, the cortex of thymic lobule, bursa nodule and Periarterial Lymphatic Sheaths thicken obviously; the volume of bursa nodule, splenic nodule and ellipsoid augmented, and the germinal center of splenic nodule were obvious; the thymic corpuscle increased; the plica of bursas of Fabricius developed well and the degenerating of it retarded.

结果表明:试验组鸡胸腺、腔上囊、脾的重量和器官指数均高于对照组,差异显著(P<0.05)或极显著(P<0.01);试验组的胸腺小叶皮质增厚,胸腺小体增多;腔上囊皱襞发达,腔上囊小结体积大,皮质较厚,退化延缓;脾的动脉周围淋巴鞘增厚,脾小结体积大,生发中心明显,椭球增大。

MethodsThe effect of curcumine on the proliferation of spleen lymphocytes through three different administration routes were determined with MTT test.

结果姜黄素体内给药和含药血清能够促进小鼠脾淋巴细胞的增殖,体外实验证实姜黄素能够抑制小鼠脾淋巴细

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